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Source: Cell Research
Vaccination: Cancer Vaccines
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Total 154 results found since Jan 2013.
Vaccination with designed neopeptides induces intratumoral, cross-reactive CD4+ T cell responses in glioblastoma
CONCLUSIONS: Turning tumor self-peptides into foreign antigens by introduction of designed mutations is a promising strategy to induce strong intratumoral CD4+ T cell responses in a cold tumor like glioblastoma.PMID:36228153 | DOI:10.1158/1078-0432.CCR-22-1741
Source: Cell Research - October 13, 2022 Category: Cytology Authors: Jian Wang Tobias Weiss Marian C Neidert Nora C Toussaint Reza Naghavian Carla Moreno Sell és Magdalena Foege Paula Tomas Ojer Gioele Medici Ivan Jelcic Daniel Schulz Elisabeth Rushing Susanne Dettwiler Barbara Schr örs Joo Heon Shin Ron McKay Catherine Source Type: research
Nanobiotherapeutic strategies to target immune microenvironment of triple-negative breast cancer
Am J Cancer Res. 2022 Sep 15;12(9):4083-4102. eCollection 2022.ABSTRACTTriple-negative breast cancer (TNBC) is the subtype with the least favourable outcomes in breast cancer. Besides chemotherapy, there is a chronic lack of other effective treatments. Advances in omic technologies have liberated us from the ambiguity of TNBC heterogeneity in terms of cancer cell and immune microenvironment in recent years. This new understanding of TNBC pathology has already led to the exploitation of novel nanoparticulate systems, including tumor vaccines, oncolytic viruses, and antibody derivatives. The revolutionary ideas in the therap...
Source: Cell Research - October 13, 2022 Category: Cytology Authors: Qing Chang Liang Chang Mo Li Liwen Fan Shunchao Bao Xinyu Wang Linlin Liu Source Type: research
Experimental study on the induction of cytotoxic T lymphocyte killing effects and dendritic-cell-based tumor vaccine prepared by high-intensity focused ultrasound
CONCLUSIONS: HIFU prepared antigen-sensitized DC could cause substantial proliferation of T cells and CTL with strong anti-tumor effects. The DC-based tumor vaccine prepared using HIFU irradiation affected active immunization on the tumor occurrence in vitro and was better than the DC-based tumor vaccine prepared using the repeated-freezing-thawing method.PMID:36204875 | DOI:10.4103/jcrt.jcrt_2291_21
Source: Cell Research - October 7, 2022 Category: Cytology Authors: Zhichao Li Guoliang Xue Zhigang Wei Xin Ye Source Type: research
Nanocarriers for cancer nano-immunotherapy
Drug Deliv Transl Res. 2022 Oct 3. doi: 10.1007/s13346-022-01241-3. Online ahead of print.ABSTRACTThe host immune system possesses an intrinsic ability to target and kill cancer cells in a specific and adaptable manner that can be further enhanced by cancer immunotherapy, which aims to train the immune system to boost the antitumor immune response. Several different categories of cancer immunotherapy have emerged as new standard cancer therapies in the clinic, including cancer vaccines, immune checkpoint inhibitors, adoptive T cell therapy, and oncolytic virus therapy. Despite the remarkable survival benefit for a subset o...
Source: Cell Research - October 3, 2022 Category: Cytology Authors: Isra Rana Jaeeun Oh Juwon Baig Jeong Hyun Moon Sejin Son Jutaek Nam Source Type: research
Nanoparticles and Nanocolloidal Carbon: Will They Be the Next Antidiabetic Class That Targets Fibrillation and Aggregation of Human Islet Amyloid Polypeptide in Type 2 Diabetes?
Acc Chem Res. 2022 Sep 29. doi: 10.1021/acs.accounts.2c00415. Online ahead of print.ABSTRACTConspectusNanotechnology is revolutionizing human medicine. Nanoparticles (NPs) are currently used for treating various cancers, for developing vaccines, and for imaging, and other promises offered by NPs might come true soon. Due to the interplay between NPs and proteins, there is more and more evidence supporting the role of NPs for treating amyloid-based diseases. NPs can induce some conformational changes of the adsorbed protein molecules via various molecular interactions, leading to inhibition of aggregation and fibrillation o...
Source: Cell Research - September 29, 2022 Category: Cytology Authors: Sabine Szunerits Amar Abderrahmani Rabah Boukherroub Source Type: research
The roles of small extracellular vesicles in cancer and immune regulation and translational potential in cancer therapy
J Exp Clin Cancer Res. 2022 Sep 27;41(1):286. doi: 10.1186/s13046-022-02492-1.ABSTRACTExtracellular vesicles (EVs) facilitate the extracellular transfer of proteins, lipids, and nucleic acids and mediate intercellular communication among multiple cells in the tumour environment. Small extracellular vesicles (sEVs) are defined as EVs range in diameter from approximately 50 to 150 nm. Tumour-derived sEVs (TDsEVs) and immune cell-derived sEVs have significant immunological activities and participate in cancer progression and immune responses. Cancer-specific molecules have been identified on TDsEVs and can function as biomark...
Source: Cell Research - September 27, 2022 Category: Cytology Authors: Kewen Qian Wenyan Fu Tian Li Jian Zhao Changhai Lei Shi Hu Source Type: research
Immunotherapy and immunobiomarker in breast cancer: current practice and future perspectives
Am J Cancer Res. 2022 Aug 15;12(8):3532-3547. eCollection 2022.ABSTRACTAmong the new cancer cases and resulting deaths among women worldwide, breast cancer is the most significant threat to women's health. In recent years, immunotherapy was initially used to treat patients with metastatic breast cancer, where it demonstrated its unique value by providing a novel way to improve therapeutic effects and prolong survival time. With the development of clinical trials related to immunotherapy for breast cancer, tumour vaccines, such as DNA vaccines, have been observed to improve the disease-free survival (DFS) and overall surviv...
Source: Cell Research - September 19, 2022 Category: Cytology Authors: Kangsheng Liu Xiaodong Mao Taiping Li Zhirong Xu Ruifang An Source Type: research
Directing the Way-Receptor and Chemical Targeting Strategies for Nucleic Acid Delivery
Pharm Res. 2022 Sep 15. doi: 10.1007/s11095-022-03385-w. Online ahead of print.ABSTRACTNucleic acid therapeutics have shown great potential for the treatment of numerous diseases, such as genetic disorders, cancer and infections. Moreover, they have been successfully used as vaccines during the COVID-19 pandemic. In order to unfold full therapeutical potential, these nano agents have to overcome several barriers. Therefore, directed transport to specific tissues and cell types remains a central challenge to receive carrier systems with enhanced efficiency and desired biodistribution profiles. Active targeting strategies in...
Source: Cell Research - September 15, 2022 Category: Cytology Authors: Ricarda Carolin Steffens Ernst Wagner Source Type: research
Dendritic cells modified by tumor associated antigen SMP30 have enhanced antitumor effect against mouse hepatocarcinoma cells in vitro and in vivo
CONCLUSION: DCs transduced with LV-SMP30 can dramatically enhance specific CD3+CD8+ T cell immune responses against mouse hepatocarcinoma cells in vitro and in vivo. These findings lend significant support to the development of the DC-based SMP30 antigen vaccine for hepatocarcinoma immunotherapy.PMID:36105050 | PMC:PMC9452339
Source: Cell Research - September 15, 2022 Category: Cytology Authors: Jinhong Guo Yaoyao Zhang Qiuhong Qin Naixia Chao Tianming Huang Chengxiao Chen Xiaoling Lu Rongshi Huang Jian Pan Source Type: research
IEAtlas: an atlas of HLA-presented immune epitopes derived from non-coding regions
Nucleic Acids Res. 2022 Sep 13:gkac776. doi: 10.1093/nar/gkac776. Online ahead of print.ABSTRACTCancer-related epitopes can engage the immune system against tumor cells, thus exploring epitopes derived from non-coding regions is emerging as a fascinating field in cancer immunotherapies. Here, we described a database, IEAtlas (http://bio-bigdata.hrbmu.edu.cn/IEAtlas), which aims to provide and visualize the comprehensive atlas of human leukocyte antigen (HLA)-presented immunogenic epitopes derived from non-coding regions. IEAtlas reanalyzed publicly available mass spectrometry-based HLA immunopeptidome datasets against our ...
Source: Cell Research - September 13, 2022 Category: Cytology Authors: Yangyang Cai Dezhong Lv Donghao Li Jiaqi Yin Yingying Ma Ya Luo Limei Fu Na Ding Yongsheng Li Zhenwei Pan Xia Li Juan Xu Source Type: research
The therapeutic effect of an autologous and allogenic mixed glioma cell lysate vaccine in a rat model
CONCLUSION: Our findings demonstrate the inhibitory effect of molecular mimic vaccines on glioma and provided a theoretical basis for molecular mimic hybrid vaccines as a potential therapeutic approach.PMID:36066620 | DOI:10.1007/s00432-022-04281-x
Source: Cell Research - September 6, 2022 Category: Cytology Authors: Haiping He Yulin Cen Ping Wang Xu Zeng Shan Zeng Xinlong Li Xiaofei Lu Chuanhong Zhong Yang Ming Ligang Chen Lilei Peng Source Type: research
Preventive cancer stem cell-based vaccination modulates tumor development in syngeneic colon adenocarcinoma murine model
CONCLUSIONS: These findings represent CSCs lysate-based vaccination as a potential approach to hampering immunotherapy failure of colorectal cancer which along with other traditional therapies may effectively apply to prevent the establishment of aggressive tumors harboring stemness features.PMID:36040667 | DOI:10.1007/s00432-022-04303-8
Source: Cell Research - August 30, 2022 Category: Cytology Authors: Leila Eini Marzieh Naseri Feridoun Karimi-Busheri Mahmood Bozorgmehr Roya Ghods Zahra Madjd Source Type: research
Disulfiram blocked cell entry of SARS-CoV-2 via inhibiting the interaction of spike protein and ACE2
Am J Cancer Res. 2022 Jul 15;12(7):3333-3346. eCollection 2022.ABSTRACTDisulfiram is an FDA-approved drug that has been used to treat alcoholism and has demonstrated a wide range of anti-cancer, anti-bacterial, and anti-viral effects. In the global COVID-19 pandemic, there is an urgent need for effective therapeutics and vaccine development. According to recent studies, disulfiram can act as a potent SARS-CoV-2 replication inhibitor by targeting multiple SARS-CoV-2 non-structural proteins to inhibit viral polyprotein cleavage and RNA replication. Currently, disulfiram is under evaluation in phase II clinical trials to trea...
Source: Cell Research - August 15, 2022 Category: Cytology Authors: Hsiao-Fan Chen Po-Ren Hsueh Yen-Yi Liu Yeh Chen Sui-Yuan Chang Wei-Jan Wang Chen-Shiou Wu Ya-Min Tsai Yu-Shu Liu Wen-Chi Su Yu-Chi Chou Mien-Chie Hung Source Type: research
Vulvar cancer incidence in the US and its relationship to human papillomavirus vaccinations, 2001-2018
Cancer Prev Res (Phila). 2022 Aug 15:CAPR-22-0086. doi: 10.1158/1940-6207.CAPR-22-0086. Online ahead of print.ABSTRACTThe human papillomavirus vaccine (HPV) was indicated for the prevention of vulvovaginal cancers in 2008, but its impact on the incidence of vulvar cancers within the US is unknown. To determine this, we conducted a secondary analysis of 88,942 vulvar cancer cases among women 20+ years old using the US Cancer Statistics 2001-2018 databases. Data were stratified by tumor behavior (in situ or invasive), age (20-44, 45-64, 65+ years old), race/ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic), and US...
Source: Cell Research - August 15, 2022 Category: Cytology Authors: Abbey B Berenson Mihyun Chang Ernest T Hawk Lois M Ramondetta Thao Hoang Source Type: research
