Filtered By:
Source: LANCET
This page shows you your search results in order of relevance. This is page number 2.
Order by Relevance | Date
Total 186 results found since Jan 2013.
Articles Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials
Our findings confirm that medical treatment substantially reduces the risk of early recurrent stroke after TIA and minor stroke and identify aspirin as the key intervention. The considerable early benefit from aspirin warrants public education about self-administration after possible TIA. The previously unrecognised effect of aspirin on severity of early recurrent stroke, the diminishing benefit with longer-term use, and the contrasting time course of effects of dipyridamole have implications for understanding mechanisms of action.
Source: LANCET - May 17, 2016 Category: Journals (General) Authors: Peter M Rothwell, Ale Algra, Zhengming Chen, Hans-Christoph Diener, Bo Norrving, Ziyah Mehta Tags: Articles Source Type: research
Articles Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study
Ten potentially modifiable risk factors are collectively associated with about 90% of the PAR of stroke in each major region of the world, among ethnic groups, in men and women, and in all ages. However, we found important regional variations in the relative importance of most individual risk factors for stroke, which could contribute to worldwide variations in frequency and case-mix of stroke. Our findings support developing both global and region-specific programmes to prevent stroke.
Source: LANCET - July 14, 2016 Category: Journals (General) Authors: Martin J O'Donnell, Siu Lim Chin, Sumathy Rangarajan, Denis Xavier, Lisheng Liu, Hongye Zhang, Purnima Rao-Melacini, Xiaohe Zhang, Prem Pais, Steven Agapay, Patricio Lopez-Jaramillo, Albertino Damasceno, Peter Langhorne, Matthew J McQueen, Annika Rosengre Tags: Articles Source Type: research
Series Stroke prevention in atrial fibrillation
Atrial fibrillation is found in a third of all ischaemic strokes, even more after post-stroke atrial fibrillation monitoring. Data from stroke registries show that both unknown and untreated or under treated atrial fibrillation is responsible for most of these strokes, which are often fatal or debilitating. Most could be prevented if efforts were directed towards detection of atrial fibrillation before stroke occurs, through screening or case finding, and treatment of all patients with atrial fibrillation at increased risk of stroke with well-controlled vitamin K antagonists or non-vitamin K antagonist anticoagulants.
Source: LANCET - August 19, 2016 Category: Journals (General) Authors: Ben Freedman, Tatjana S Potpara, Gregory Y H Lip Tags: Series Source Type: research
Seminar Stroke
In the past decade, the definition of stroke has been revised and major advances have been made for its treatment and prevention. For acute ischaemic stroke, the addition of endovascular thrombectomy of proximal large artery occlusion to intravenous alteplase increases functional independence for a further fifth of patients. The benefits of aspirin in preventing early recurrent ischaemic stroke are greater than previously recognised. Other strategies to prevent recurrent stroke now include direct oral anticoagulants as an alternative to warfarin for atrial fibrillation, and carotid stenting as an alternative to endarterect...
Source: LANCET - September 12, 2016 Category: Journals (General) Authors: Graeme J Hankey Tags: Seminar Source Type: research
Correspondence Unmet challenges for rehabilitation after stroke in China
Stroke is an important public health problem in China, and is one of the leading causes of death and disability. About 2 500 000 people have a stroke in China every year, and 70–80% of patients lose the ability to perform routine activities and require care, resulting in an economic burden for both the country and their family.1 Japan has a similar incidence of stroke because of similar ancestry, but outcomes a fter stroke are better in Japan than in China. In Japan, 64·2% of young patients (age
Source: LANCET - July 7, 2017 Category: General Medicine Authors: Tetsuya Asakawa, Liang Zong, Liang Wang, Ying Xia, Hiroki Namba Tags: Correspondence Source Type: research
Editorial Stroke —acting FAST at all ages
On Feb 1, Public Health England released new estimates for the incidence of first stroke in England and relaunched its Act FAST campaign. FAST is aimed at the public, encouraging them to call 999 —the UK's emergency number—if there are tell-tale signs of stroke in themselves or anyone they see. FAST stands for face, arms, speech, and time (to call). The new estimates showed that about 57 000 new strokes and 32 000 stroke-related deaths occur every year in England. Of those who have e xperienced a stroke, about a quarter leave hospital with moderate or severe disability.
Source: LANCET - February 9, 2018 Category: General Medicine Authors: The Lancet Tags: Editorial Source Type: research
Correspondence Intermittent pneumatic compression in patients with stroke
We read with great interest the Article by the CLOTS (Clots in Legs Or sTockings after Stroke) Trials Collaboration (Aug 10, p 516) that assessed intermittent pneumatic compression (IPC) in immobile patients with acute stroke. Patients were allocated to receive either IPC or no IPC. The authors conclude that IPC is an effective method of reducing the risk of deep vein thrombosis (DVT) and possibly improving survival in patients who are immobile after stroke.
Source: LANCET - November 2, 2013 Category: Journals (General) Authors: Johann Auer, Robert Berent, Franz Gurtner Tags: Correspondence Source Type: research
Comment The worldwide landscape of stroke in the 21st century
Assessment of the epidemiology of stroke is a difficult but exciting challenge that is justified by the objectives of identifying vascular risk factors, establishment of needs for the implementation of dedicated services, and guiding and assessment of future preventive and therapeutic priorities. Prospective population-based stroke registries are ideal methods to provide reliable and optimum information about stroke epidemiology, provided they comply with established quality criteria.
Source: LANCET - January 17, 2014 Category: Journals (General) Authors: Maurice Giroud, Agnès Jacquin, Yannick Béjot Tags: Comment Source Type: research
Correspondence Global burden of stroke: an underestimate
The global burden of stroke outlined by Valery Feigin and colleagues' Article (Jan 18, p 245) is likely to be a substantial underestimation in view of the consequences of stroke disease on conditions other than acute stroke, which substantially affect health and wellbeing. Overt and occult cerebrovascular disease, both large and small vessel, have been recognised to contribute to Alzheimer's disease and vascular dementia.
Source: LANCET - April 4, 2014 Category: Journals (General) Authors: Desmond O'Neill Tags: Correspondence Source Type: research
Comment Alteplase in acute ischaemic stroke: the need for speed
Doctors treating patients who have had an acute ischaemic stroke must feel the need for speed more feverishly than a racing driver. Stroke does not hurt. There is none of the pain that might be registered on the face of a patient with acute myocardial infarction or the visceral sight of blood in the case of trauma to evoke a sense of immediacy. Yet stroke is exactly like acute myocardial infarction and acute trauma in the need for very fast treatment.
Source: LANCET - November 28, 2014 Category: Journals (General) Authors: Michael D Hill, Shelagh B Coutts Tags: Comment Source Type: research
Comment Blood pressure in acute stroke: which questions remain?
In ENOS, one of the largest randomised trials of blood pressure-lowering in acute stroke now published in The Lancet, Philip Bath and colleagues1 assessed whether blood pressure could be safely lowered with a daily glyceryl nitrate patch for 7 days after acute stroke, and whether antihypertensive drugs should be continued or withdrawn. Blood pressure is increased in about 70% of patients with acute stroke and often falls spontaneously over the next few days.2 The potential causes of this transient rise include disturbed cerebral autoregulation, damage or compression of brain regions that regulate blood pressure, neuroendoc...
Source: LANCET - October 21, 2014 Category: Journals (General) Authors: Peter M Rothwell Tags: Comment Source Type: research
Correspondence Thrombolysis in acute stroke
In a meta-analysis of individual patient data on alteplase for acute ischaemic stroke, Jonathan Emberson and colleagues1 show that alteplase significantly improves the overall likelihood of a good stroke outcome in patients treated up to at least 4·5 h after first symptom of stroke. However, in view of adverse events, we think these results should be interpreted more cautiously.
Source: LANCET - April 10, 2015 Category: Journals (General) Authors: Mattias Brunström, Bo Carlberg Tags: Correspondence Source Type: research
Correspondence The future of stroke therapy must not be mired by past arguments
Stroke is the leading cause of disability and the fifth leading cause of death in the UK, costing the UK economy more than £7 billion per year.1 At present, the only therapeutic approved by the UK National Institute for Health and Care Excellence (NICE) for the treatment of ischaemic stroke is thrombolysis using recombinant tissue-type plasminogen activator (rtPA). However, rtPA is only effective in patients who present within 4·5 h of stroke onset, with a number needed to treat for benefit of 3·6 before 90 min, rising to 5·9 between 3 h and 4·5 h.
Source: LANCET - August 14, 2015 Category: Journals (General) Authors: Alastair M Buchan, Hasneen G Karbalai, Brad A Sutherland Tags: Correspondence Source Type: research
Correspondence Could upright posture be harmful in the early stages of stroke?
Findings from the AVERT trial (July 4, p 46)1 have effectively slain a long cherished theory of stroke unit enthusiasts, that the sooner mobilisation and active rehabilitation begin after stroke, the better. In fact, evidence of a small, but significant, harmful effect of early mobilisation was found. After adjusting for age and stroke severity, and applying the prespecified cutoff for favourable outcome on the modified Rankin scale, we estimate that one in 13 patients (95% CI 8–40) had worse outcome with early mobilisation than with standard treatment.
Source: LANCET - October 30, 2015 Category: Journals (General) Authors: David Barer, Caroline Watkins Tags: Correspondence Source Type: research
