Editorial Stroke —acting FAST at all ages

On Feb 1, Public Health England released new estimates for the incidence of first stroke in England and relaunched its Act FAST campaign. FAST is aimed at the public, encouraging them to call 999 —the UK's emergency number—if there are tell-tale signs of stroke in themselves or anyone they see. FAST stands for face, arms, speech, and time (to call). The new estimates showed that about 57 000 new strokes and 32 000 stroke-related deaths occur every year in England. Of those who have e xperienced a stroke, about a quarter leave hospital with moderate or severe disability.
Source: LANCET - Category: General Medicine Authors: Tags: Editorial Source Type: research

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Conclusion: The use of PED to treat aneurysms located outside the circle of Willis is feasible and effective. Our novel antiplatelet protocol did not require platelet function assay testing and did not lead to a higher rate of thrombo-embolic events compared to what has been previously reported.Intervent Neurol 2019;8:83 –91
Source: Interventional Neurology - Category: Neurology Source Type: research
Conditions:   Stroke;   Knowledge, Attitudes, Practice;   Physical Disability;   Motor Skills Disorders Intervention:   Other: Implementation of stroke mobility guidelines Sponsors:   McGill University;   Heart and Stroke Foundation of Canada - Canadian Partnership for Stroke Recovery;   Réseau Provincial De Recherche En Adaptation-Réadaptation (REPAR) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: The burden of disease was higher in the population with disabilities than that in the general population. Cardiovascular diseases and cancer had a higher burden of disease than did other diseases in the population with disabilities; thus, overall, non-communicable diseases have a higher burden of disease than communicable diseases or injuries in the population with disabilities than in the general population. PMID: 30636948 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Assessing lower limb position sense in stroke using the gradient discrimination test (GradDT™) and step-height discrimination test (StepDT™): a reliability and validity study. Disabil Rehabil. 2019 Jan 14;:1-9 Authors: Gorst T, Freeman J, Yarrow K, Marsden J Abstract PURPOSE: To evaluate the psychometric properties of two novel tests of lower limb position sense. METHODS: Our newly developed tests assess the discrimination thresholds of under-foot slope and step height perception using a two alternative forced choice approach. Stroke participants (n = 32) and age matched...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Non-traumatic intracerebral hemorrhage (ICH) is associated with a significant global burden of disease, and despite being proportionally less frequent than ischemic stroke, in 2010 it was associated with greater worldwide disability-adjusted life years lost. The focus of outcome assessment after ICH has been mortality in most studies, because of the high early case fatality which reaches 40% in some population-based studies. The most robust and consistent predictors of early mortality include age, severity of neurological impairment, hemorrhage volume and antithrombotic therapy at the time of the event.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Review Article Source Type: research
Cryptococcal meningitis carries a high mortality, and survivors are left with considerable neurologic sequelae and marked disability. We lack a clear understanding of the pathogenesis of neurologic sequelae and description of stroke features in this population. We aim to describe clinical and radiographic features and predictors of stroke in a cohort of patients with cryptococcal meningitis.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
Purpose of review A substantial proportion of patients with ischemic stroke present with mild neurological deficits ('Stroke with mild symptoms,’ SMS). Treating these patients with thrombolysis or with thrombectomy is controversial and clinical practice is different. We will highlight the importance of these treatment decisions by reviewing the recent advances in this area. Recent findings Intravenous thrombolysis with recombinant tissue plasminogen activator in patients with SMS showed a significant reduction in functional disability after 3 months. Treatment with tenecteplase seems to be a pharmacologically su...
Source: Current Opinion in Neurology - Category: Neurology Tags: CEREBROVASCULAR DISEASE: Edited by Didier Leys Source Type: research
Purpose of review To address the important relationships between stroke and infection, focusing on the most frequent infections found in low-income and middle-income countries. Recent findings Stroke is one of the leading causes of mortality and disability worldwide, with a great proportion of the stroke burden occurring in low-income and middle-income countries. Infectious diseases are still a great health problem in developing countries and it is possible that the proportion of infection-related strokes is greater in these nations. Infectious diseases and stroke have a bidirectional relationship. Common infections m...
Source: Current Opinion in Neurology - Category: Neurology Tags: CEREBROVASCULAR DISEASE: Edited by Didier Leys Source Type: research
This study investigated the effect of microRNA mir363-3p treatment on PSD using a physiologically-relevant animal model. Our previous work showed that mir363-3p treatment, delivered post-stroke, effectively reduces infarct volume in the acute phase of stroke in middle-aged females but not males. Middle-aged female Sprague Dawley rats were tested for baseline sensory motor function and depressive-like behaviors, and then subjected to ischemic stroke via middle cerebral artery occlusion (MCAo) or sham surgery. Animals received either control oligos (MCAo+scrambled, Sham+scrambled) or mir363-3p (MCAo+mir363-3p, Sham+mir363-3p...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
miR‑29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4. Oncol Rep. 2019 Jan 09;: Authors: Zheng Y, Pan C, Chen M, Pei A, Xie L, Zhu S Abstract Ischemic stroke is the main cause of brain injury and results in a high rate of morbidity, disability and mortality. In the present study, we aimed to determine whether miR‑29a played a protective role in oxygen glucose deprivation (OGD) injury via regulation of the water channel protein aquaporin 4 (AQP4). Real‑time PCR and western blotting were used to assess miR‑29a levels and AQP4 protein levels,...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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