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Source: Haematologica

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Total 41 results found since Jan 2013.

Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction.
Abstract Silent cerebral infarction is the commonest neurological abnormality in children with sickle cell anemia, affecting 30-40% 14 year olds. There are no known biomarkers to identify children with silent cerebral infarcts and the pathological basis is also unknown. We used an unbiased proteomic discovery approach to identify plasma proteins differing in concentration between children with and without silent cerebral infarcts. Clinical parameters and plasma samples were analysed from 51 children (mean age 11.8 years, range 6-18) with sickle cell anemia (HbSS). 19 children had silent cerebral infarcts and 32 no...
Source: Haematologica - March 15, 2018 Category: Hematology Authors: Tewari S, Renney G, Brewin J, Gardner K, Kirkham F, Inusa B, Barrett JE, Menzel S, Thein SL, Ward M, Rees DC Tags: Haematologica Source Type: research

Frequency, risk factors, and impact on mortality of arterial thromboembolism in patients with cancer.
Abstract In contrast to venous thromboembolism, little is known about arterial thromboembolism in patients with cancer. The aim of this study was to quantify the risk and explore clinical risk factors of arterial thromboembolism in patients with cancer, and investigate its potential impact on mortality. Patients with newly-diagnosed cancer or progression of disease after remission were included in a prospective observational cohort study and followed for 2 years. Between October 2003 and October 2013, 1880 patients (54.3% male; median age: 61 years) were included. During a median follow-up of 723 days, 48 (2.6%) p...
Source: Haematologica - May 24, 2018 Category: Hematology Authors: Grilz E, Königsbrügge O, Posch F, Schmidinger M, Pirker R, Lang IM, Pabinger I, Ay C Tags: Haematologica Source Type: research

Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents.
We report here that stimulated platelets switch their energy metabolism to aerobic glycolysis by modulating enzymes at key checkpoints in glucose metabolism. We found aerobic glycolysis to, in turn, accelerate flux through pentose phosphate pathway and support platelet activation. Hence, reversing metabolic adaptations of platelets could be an effective alternative to conventional anti-platelet approaches that are crippled by remarkable redundancy in platelet agonists and ensuing signaling pathways. Concurring with this proposition, small-molecule modulators of pyruvate dehydrogenase, pyruvate kinase M2 and glucose-6-phosp...
Source: Haematologica - October 31, 2018 Category: Hematology Authors: Kulkarni PP, Tiwari A, Singh N, Gautam D, Sonkar VK, Agarwal V, Dash D Tags: Haematologica Source Type: research

Thromboinflammatory mechanisms in sickle cell disease - challenging the hemostatic balance.
Abstract Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell properties and shape, as the result of HbS dexoygenation and subsequent polymerization. SCD pathophysiology is characterized by chronic inflammatory processes, triggered by hemolytic and vaso-occlusive events, which lead to the varied complications, organ damage and elevated mortality seen in individuals with the disease. In association with activation of the endothelium and leukocytes, hemostatic alterations and thrombotic events a...
Source: Haematologica - May 20, 2020 Category: Hematology Authors: Conran N, De Paula EV Tags: Haematologica Source Type: research

Chronic organ injuries in children with sickle cell disease
Haematologica. 2021 Feb 25. doi: 10.3324/haematol.2020.271353. Online ahead of print.ABSTRACTMedian life expectancy of patients with sickle cell disease has increased to up to 55 years but there are still frequent cases of premature death, mostly in patients with pre-existing organ failure such as pulmonary hypertension, kidney injury, and cerebral vasculopathy. Most organ injuries remain asymptomatic for a long time and can only be detected through early systematic screening. Protocols combining assessment of velocities on transcranial Doppler and regular transfusions in patients with abnormal velocities have been demonst...
Source: Haematologica - February 25, 2021 Category: Hematology Authors: Slimane Allali Melissa Taylor Jos éphine Brice Mariane de Montalembert Source Type: research

Red cell transfusion and alloimmunization in sickle cell disease
Haematologica. 2021 Apr 1. doi: 10.3324/haematol.2020.270546. Online ahead of print.ABSTRACTRed cell transfusion remains a critical component of care for acute and chronic complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of transfusion therapy for prevention of primary and secondary strokes and postoperative acute chest syndrome. Transfusion for splenic sequestration, acute chest syndrome, and acute stroke are guided by expert consensus recommendations. Despite overall improvements in blood inventory safety, adverse effects of transfusion are prevalent among patients with sickle ce...
Source: Haematologica - April 1, 2021 Category: Hematology Authors: Grace E Linder Stella T Chou Source Type: research

Complement dysregulation is associated with severe COVID-19 illness
Haematologica. 2021 Jul 22. doi: 10.3324/haematol.2021.279155. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may manifest as thrombosis, stroke, renal failure, myocardial infarction, and thrombocytopenia, reminiscent of other complement-mediated diseases. Multiple clinical and preclinical studies have implicated complement in the pathogenesis of COVID-19 illness. We previously found that the SARS-CoV-2 spike protein activates the alternative pathway of complement (APC) in vitro through interfering with the function of complement factor H, a key negative regulator of APC. Here, w...
Source: Haematologica - July 22, 2021 Category: Hematology Authors: Jia Yu Gloria F Gerber Hang Chen Xuan Yuan Shruti Chaturvedi Evan M Braunstein Robert A Brodsky Source Type: research