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Standard and reduced doses of dabigatran, rivaroxaban, and apixaban for stroke prevention in atrial fibrillation: a nationwide cohort study
ConclusionsStandard and reduced dose NOACs, respectively, showed no significant risk difference for associated stroke/thromboembolism. Rivaroxaban was associated with higher bleeding risk compared with dabigatran and apixaban, and dabigatran was associated with lower intracranial bleeding risk compared with rivaroxaban and apixaban.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 1, 2017 Category: Internal Medicine Authors: Laila Staerk, Thomas A Gerds, Gregory Y H Lip, Brice Ozenne, Anders N Bonde, Morten Lamberts, Emil L Fosb øl, Christian Torp‐Pedersen, Gunnar H Gislason, Jonas B Olesen Tags: Original Article Source Type: research

Standard and reduced doses of dabigatran, rivaroxaban and apixaban for stroke prevention in atrial fibrillation: a nationwide cohort study
ConclusionsStandard and reduced dose NOACs, respectively, showed no significant risk difference for associated stroke/thromboembolism. Rivaroxaban was associated with higher bleeding risk compared with dabigatran and apixaban and dabigatran was associated with lower intracranial bleeding risk compared with rivaroxaban and apixaban.
Source: Journal of Internal Medicine - September 21, 2017 Category: Internal Medicine Authors: L. Staerk, T. A. Gerds, G. Y. H. Lip, B. Ozenne, A. N. Bonde, M. Lamberts, E. L. Fosb øl, C. Torp‐Pedersen, G. H. Gislason, J. B. Olesen Tags: Original Article Source Type: research

Current evidence for endovascular therapy in stroke and remaining uncertainties (R1)
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - July 20, 2017 Category: Internal Medicine Authors: Ronan Motyer, Hamed Asadi, John Thornton, Patrick Nicholson, Hong Kuan Kok Tags: Review Source Type: research

Current evidence for endovascular therapy in stroke and remaining uncertainties
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - July 20, 2017 Category: Internal Medicine Authors: Ronan Motyer, Hamed Asadi, John Thornton, Patrick Nicholson, Hong Kuan Kok Tags: Review Source Type: research

Proton ‐Pump Inhibitor Use and the Risk of First‐Time Ischemic Stroke in the General Population
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - October 28, 2017 Category: Internal Medicine Authors: Cong Dai, Min Jiang, Qin Cao Tags: Letter to the Editor Source Type: research

Risk of thromboembolism and fatal stroke in patients with psoriasis and non‐valvular atrial fibrillation: a Danish nationwide cohort study
ConclusionsIn patients with non‐valvular atrial fibrillation not treated with oral anticoagulation severe psoriasis was associated with increased risk of thromboembolism. In these patients CHA2DS2VASc underestimated the risk of thromboembolism.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - May 1, 2014 Category: Internal Medicine Authors: Ole Ahlehoff, Gunnar Gislason, Morten Lamberts, Fredrik Folke, Jesper Lindhardsen, Carsten Toftager Larsen, Christian Torp‐Pedersen, Peter Riis Hansen Tags: Original Article Source Type: research

Risk of thromboembolism and fatal stroke in patients with psoriasis and nonvalvular atrial fibrillation: a Danish nationwide cohort study
ConclusionsIn patients with nonvalvular atrial fibrillation not treated with oral anticoagulation, severe psoriasis was associated with increased risk of thromboembolism. In these patients, CHA2DS2VASc underestimated the risk of thromboembolism.
Source: Journal of Internal Medicine - June 13, 2014 Category: Internal Medicine Authors: O. Ahlehoff, G. Gislason, M. Lamberts, F. Folke, J. Lindhardsen, C. T. Larsen, C. Torp‐Pedersen, P. R. Hansen Tags: Original Article Source Type: research

Outcomes of endovascular treatment for acute large vessel ischemic stroke more than 6 hours after symptom onset
ConclusionsIn appropriately selected patients, EVT >6 hours was associated with comparable outcomes to those treated <6 hours. These data support a physiological approach to patient selection.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 5, 2017 Category: Internal Medicine Authors: Ronan Motyer, Hong Kuan Kok, Hamed Asadi, Alan O'Hare, Paul Brennan, Sarah Power, Seamus Looby, Patrick Nicholson, David Williams, Sean Murphy, Michael D. Hill, Mayank Goyal, John McManus, Paul O'Brien, John Thornton Tags: Original Article Source Type: research

Outcomes of endovascular treatment for acute large ‐vessel ischaemic stroke more than 6 h after symptom onset
ConclusionsIn appropriately selected patients, EVT >6 h was associated with comparable outcomes to those treated <6 h. These data support a physiological approach to patient selection.
Source: Journal of Internal Medicine - September 25, 2017 Category: Internal Medicine Authors: R. Motyer, H. K. Kok, H. Asadi, A. O'Hare, P. Brennan, S. Power, S. Looby, P. Nicholson, D. Williams, S. Murphy, M. D. Hill, M. Goyal, J. McManus, P. O'Brien, J. Thornton Tags: Original Article Source Type: research

CCL23 is a promising biomarker of injury in patients with ischemic stroke
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - February 1, 2018 Category: Internal Medicine Authors: Aldo Bonaventura, Fabrizio Montecucco Tags: Editorial Comment Source Type: research

Cardiovascular risk in patients with sleep apnea with or without continuous positive airway pressure therapy: follow‐up of 4.5 million Danish adults
ConclusionsSleep apnoea is associated with increased risk of ischaemic stroke and MI, particularly in patients younger than 50 years of age. CPAP therapy was not associated with a reduced rate of stroke or MI.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - August 28, 2014 Category: Internal Medicine Authors: M. Lamberts, O. W. Nielsen, G. Y. H. Lip, M. H. Ruwald, C. B. Christiansen, S. L. Kristensen, C. Torp‐Pedersen, M. L. Hansen, G. H. Gislason Tags: Original Source Type: research

Cardiovascular risk in patients with sleep apnoea with or without continuous positive airway pressure therapy: follow‐up of 4.5 million Danish adults
ConclusionsSleep apnoea is associated with increased risk of ischaemic stroke and MI, particularly in patients younger than 50 years of age. CPAP therapy was not associated with a reduced rate of stroke or MI.
Source: Journal of Internal Medicine - September 17, 2014 Category: Internal Medicine Authors: M. Lamberts, O. W. Nielsen, G. Y. H. Lip, M. H. Ruwald, C. B. Christiansen, S. L. Kristensen, C. Torp‐Pedersen, M. L. Hansen, G. H. Gislason Tags: Original Article Source Type: research

Alcohol and cardiovascular diseases: where do we stand today?
Abstract For centuries, multiple medical risks of heavy alcohol drinking have been evident with simultaneous awareness of a less harmful or sensible drinking limit. The increased risks of heavy drinking, defined as three or more standard‐sized drinks per day, are both cardiovascular (CV) and non‐CV. The CV risks include the following: (i) alcoholic cardiomyopathy (ACM), (ii) systemic hypertension, (iii) atrial arrhythmias, (iv) haemorrhagic stroke and, probably, ischaemic stroke. By contrast, modern epidemiological studies have shown lower morbidity and mortality amongst light–moderate drinkers, due mostly to a reduc...
Source: Journal of Internal Medicine - July 8, 2015 Category: Internal Medicine Authors: A. L. Klatsky Tags: Review Source Type: research

Reply to “Important factors affecting the choice of an oral anticoagulant may be missed in database studies”
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 28, 2017 Category: Internal Medicine Authors: Anna Gundlund, Emil Loldrup Fosb øl, Jonas Bjerring Olesen Tags: Letter to the Editor Source Type: research

Atrial Fibrillation Prevalence Revisited
ConclusionThe prevalence of atrial fibrillation is at least 2.9% of the Swedish adult population, not counting “silent atrial fibrillation”. The official US figures probably underestimate the magnitude of the problem by a factor of 3 to 5. More than 80% had risk factors motivating anticoagulation therapy.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - July 27, 2013 Category: Internal Medicine Authors: Leif Friberg, Lennart Bergfeldt Tags: Original Source Type: research

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