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Total 25 results found since Jan 2013.

Moderate-intensity cardiovascular exercise performed before motor practice attenuates offline implicit motor learning in stroke survivors but not age-matched neurotypical adults
Exp Brain Res. 2023 Jul 3. doi: 10.1007/s00221-023-06659-w. Online ahead of print.ABSTRACTThe acute impact of cardiovascular exercise on implicit motor learning of stroke survivors is still unknown. We investigated the effects of cardiovascular exercise on implicit motor learning of mild-moderately impaired chronic stroke survivors and neurotypical adults. We addressed whether exercise priming effects are time-dependent (e.g., exercise before or after practice) in the encoding (acquisition) and recall (retention) phases. Forty-five stroke survivors and 45 age-matched neurotypical adults were randomized into three sub-group...
Source: Brain Research - July 3, 2023 Category: Neurology Authors: Giordano Marcio Gatinho Bonuzzi Flavio Henrique Bastos Nicolas Schweighofer Eric Wade Carolee Joyce Winstein Camila Torriani-Pasin Source Type: research

Explicit motor sequence learning after stroke: a neuropsychological study
Exp Brain Res. 2021 Jun 5. doi: 10.1007/s00221-021-06141-5. Online ahead of print.ABSTRACTMotor learning interacts with and shapes experience-dependent cerebral plasticity. In stroke patients with paresis of the upper limb, motor recovery was proposed to reflect a process of re-learning the lost/impaired skill, which interacts with rehabilitation. However, to what extent stroke patients with hemiparesis may retain the ability of learning with their affected limb remains an unsolved issue, that was addressed by this study. Nineteen patients, with a cerebrovascular lesion affecting the right or the left hemisphere, underwent...
Source: Brain Research - June 6, 2021 Category: Neurology Authors: Cristina Russo Laura Veronelli Carlotta Casati Alessia Monti Laura Perucca Francesco Ferraro Massimo Corbo Giuseppe Vallar Nadia Bolognini Source Type: research

Enhanced error facilitates motor learning in weight shift and increases use of the paretic leg during walking at chronic stage after stroke
In conclusion, applying pelvis resistance forces to increase error signals may facilitate motor learning of weight shift toward the paretic side and enhance use of the paretic leg in chronic stroke survivors. Results from this study may be utilized to develop an intervention approach to improve walking in stroke survivors.PMID:34477919 | DOI:10.1007/s00221-021-06202-9
Source: Brain Research - September 3, 2021 Category: Neurology Authors: Seoung Hoon Park Chao-Jung Hsu Weena Dee Elliot J Roth William Z Rymer Ming Wu Source Type: research

Gradual adaptation to pelvis perturbation during walking reinforces motor learning of weight shift toward the paretic side in individuals post-stroke
In conclusion, the "gradual adaptation" inducing "small errors" during constraint-induced walking may improve weight shift and enhance forced use of the paretic leg in individuals post-stroke. Applying gradual pelvis assistance force during walking may be used as an intervention strategy to improve walking in individuals post-stroke.PMID:33779790 | DOI:10.1007/s00221-021-06092-x
Source: Brain Research - March 29, 2021 Category: Neurology Authors: Seoung Hoon Park Chao-Jung Hsu Weena Dee Elliot J Roth William Z Rymer Ming Wu Source Type: research

The Relationship between Altered Degree Centrality and Cognitive Function in Mild Subcortical Stroke: A Resting-State fMRI Study
CONCLUSIONS: DC values were increased in the right PhG following a mild subcortical stroke. DC values in the PhG were negatively correlated with cognitive function, which may indicate brain nodes reorganization.PMID:36265670 | DOI:10.1016/j.brainres.2022.148125
Source: Brain Research - October 20, 2022 Category: Neurology Authors: Yan Min Chang Liu Lijun Zuo Yongjun Wang Zixiao Li Source Type: research

Silencing lncRNA HOTAIR improves the recovery of neurological function in ischemic stroke via the miR-148a-3p/KLF6 axis
In this study, we explored the effect and potential molecular mechanism of lncRNA homeobox antisense non-coding RNA (HOTAIR) in IS. Permanent middle cerebral artery occlusion (pMCAO) model and oxygen and glucose deprivation (OGD) model were established. HOTAIR was increased in vivo and in vitro models post-ischemic. HOTAIR knockdown promoted neurological function recovery, manifesting in decreased modified neurological severity score, cerebral infarcted area, apoptosis and inflammation, and improved balance ability, spatial learning and memory ability. Silencing HOTAIR also improved the viability of OGD-induced N2a cells, ...
Source: Brain Research - August 15, 2021 Category: Neurology Authors: Yiwen Huang Yuanyuan Wang Xiaobin Liu Yingjun Ouyang Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

Promotion of Momordica Charantia polysaccharides on neural stem cell proliferation by increasing SIRT1 activity after cerebral ischemia/reperfusion in rats
Brain Res Bull. 2021 Feb 26:S0361-9230(21)00058-7. doi: 10.1016/j.brainresbull.2021.02.016. Online ahead of print.ABSTRACTThe deacetylase SIRT1 has been reported to play a critical role in regulating neurogenesis, which may be an adaptive processes contributing to recovery after stroke. Our previous work showed that the antioxidant capacity of Momordica charantia polysaccharides (MCPs) could protect against cerebral ischemia/reperfusion (I/R) after stroke. However, whether the protective effect of MCPs on I/R injury is related to NSCs proliferation remains unclear. In the present study, we designed in vivo and in vitro exp...
Source: Brain Research - March 1, 2021 Category: Neurology Authors: Juyun Ma Haidi Fan Heng Cai Zhaoli Hu Xiaoling Zhou Fengying Li Hansen Chen Jiangang Shen Suhua Qi Source Type: research

Brain Stimulation: Neuromodulation as a Potential Treatment for Motor Recovery Following Traumatic Brain Injury.
Abstract There is growing evidence that electrical and magnetic brain stimulation can improve motor function and motor learning following brain damage. Rodent and primate studies have strongly demonstrated that combining cortical stimulation (CS) with skilled motor rehabilitative training enhances functional motor recovery following stroke. Brain stimulation following traumatic brain injury (TBI) is less well studied, but early pre-clinical and human pilot studies suggest that it is a promising treatment for TBI-induced motor impairments as well. This review will first discuss the evidence supporting brain stimula...
Source: Brain Research - February 5, 2016 Category: Neurology Authors: Clayton E, Kinley-Cooper SK, Weber RA, Adkins DL Tags: Brain Res Source Type: research

Aberrant CaMKII activity in the medial prefrontal cortex is associated with cognitive dysfunction in ADHD model rats.
Abstract Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurobehavioral disorder accompanied by cognitive and learning deficits, which is prevalent among boys. Juvenile male stroke-prone spontaneously hypertensive rats (SHRSP) exhibit ADHD-like behaviors including cognitive deficits and represent one animal model of ADHD. Here, we define a mechanism underlying cognitive dysfunction observed in SHRSP. Acute methylphenidate (MPH: 1mg/kg, p.o.) administration to SHRSP significantly improved not only inattention in a Y-maze task but also cognitive dysfunction in a novel object recognition test. Int...
Source: Brain Research - February 19, 2014 Category: Neurology Authors: Yabuki Y, Shioda N, Maeda T, Hiraide S, Togashi H, Fukunaga K Tags: Brain Res Source Type: research