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Impaired perfusion modifies the relationship between blood pressure and stroke risk in major cerebral artery disease
Conclusions Impaired perfusion modified the relationship between blood pressure and stroke risk, although this study had limitations including the retrospective analysis, the potentially biased sample, the small number of critical events and the fact that BP was measured only as a snapshot in clinic.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Yamauchi, H., Higashi, T., Kagawa, S., Kishibe, Y., Takahashi, M. Tags: Open access, Stroke, Hypertension, Radiology, Radiology (diagnostics) Cerebrovascular disease Source Type: research

Ct perfusion in acute ischaemic stroke: do we cover the lesion and what does it mean?
Conclusions Even with limited z–directional coverage CTP is more sensitive than NCCT ASPECTS scoring to detect evidence of acute stroke. In this cohort CTP acquisition at the basal ganglia was more often too inferior than it was too superior to maximise lesion coverage. Patients without perfusion deficits have better functional outcomes than those with perfusion deficits.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Collins, P., Dani, K., Moreton, F., McVerry, F., MacDougall, N., Macleod, M. J., Wardlaw, J., Muir, K. Tags: Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Endovascular treatment beyond 24 hours from the onset of acute ischemic stroke: the Italian Registry of Endovascular Thrombectomy in Acute Stroke (IRETAS)
Conclusions These findings suggest that, in a real world setting, very late endovascular therapy is feasible in appropriately selected patients.
Source: Journal of NeuroInterventional Surgery - November 14, 2022 Category: Neurosurgery Authors: Casetta, I., Fainardi, E., Pracucci, G., Saia, V., Vallone, S., Zini, A., Bergui, M., Cerrato, P., Nappini, S., Nencini, P., Gasparotti, R., Saletti, A., Causin, F., Romano, D., Burdi, N., Giorgianni, A., Mangiafico, S., Toni, D., The Italian Registry of Tags: Ischemic stroke Source Type: research

Incidence and mechanisms of stroke after permanent carotid artery occlusion following temporary occlusion testing
Conclusions The rate of ischemic stroke following carotid sacrifice remains high and most strokes are thromboembolic in nature. Our testing protocol did not eliminate the risk of hypoperfusion-related stroke. Delayed venous phase by angiography may be a better indicator of hemodynamic tolerance than perfusion imaging.
Source: Journal of NeuroInterventional Surgery - May 14, 2015 Category: Neurosurgery Authors: Whisenant, J. T., Kadkhodayan, Y., Cross, D. T., Moran, C. J., Derdeyn, C. P. Tags: Ischemic stroke Source Type: research

Correlation between cerebral blood volume values and outcomes in endovascular therapy for acute ischemic stroke
Conclusions We found that cortical CBV loss is predictive of poor clinical outcomes, whereas basal ganglia CBV loss is predictive of hemorrhagic transformation but without translation into poor clinical outcomes. Our study findings support published results of baseline preintervention CBV as a predictor of outcomes in patients undergoing intra-arterial stroke therapies.
Source: Journal of NeuroInterventional Surgery - September 13, 2015 Category: Neurosurgery Authors: Mokin, M., Morr, S., Fanous, A. A., Shallwani, H., Natarajan, S. K., Levy, E. I., Snyder, K. V., Siddiqui, A. H. Tags: Ischemic stroke Source Type: research

Interaction of age with the ischaemic penumbra, leptomeningeal collateral circulation and haemodynamic variables in acute stroke: a pilot study
Conclusions These findings, described for the first time in a clinical cohort using whole brain CT perfusion and concomitant vascular imaging, suggest that age has a differential effect on acute tissue compartments in the wake of a preserved collateral vascular response and haemodynamic parameters. In agreement with the preclinical literature, the results point to a distinct tissue response to acute ischaemia in the ageing brain and merit validation studies in larger cohorts, particularly in relation to clinical outcomes.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Agarwal, S., Scoffings, D. J., Jones, P. S., Marrapu, S. T., Barry, P. J., O'Brien, E. W., Baron, J.-C., Warburton, E. A. Tags: Stroke, Radiology, Radiology (diagnostics) Cerebrovascular disease Source Type: research

Large ct perfusion-defined mismatch predicts early improvement after iv thrombolysis in acute ischaemic stroke
Conclusions Acute CTP mismatch ratio predicted early neurological improvement after IV rtPA treatment, with large mismatch ratios yielding better prediction of favourable early response. The combination of NIHSS and CTP mismatch may improve prediction of poor outcome. Since all patients received rtPA, no conclusion can be made about the interaction between imaging variables and rtPA.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Collins, P. D., Dani, K. A., Moreton, F., Huang, X., MacDougall, N. J., McVerry, F., Macleod, M. J., Wardlaw, J. M., Muir, K. W. Tags: Stroke, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

The halifax acute stroke imaging study (hasis): does ct perfusion scanning in acute ischemic stroke predict final infarct volume?
Conclusions Results from HASIS suggest information from admission CTP and SI in suspected AIS patients can predict final infarct volume, where final volume of infarcted brain will not be smaller than that predicted by CTP CBV or CTA SI.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Langlands, G., Shankar, J., Simpkin, W., Christian, C., Phillips, S. Tags: Stroke, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Risk of acute kidney injury associated with neuroimaging obtained during triage and treatment of patients with acute ischemic stroke symptoms
Conclusions This study provides preliminary evidence of the safety and feasibility of obtaining CTSS with additional DSA imaging, whether for diagnosis or intervention, to identify possible acute ischemic stroke.
Source: Journal of NeuroInterventional Surgery - November 14, 2016 Category: Neurosurgery Authors: Hall, S. L., Munich, S. A., Cress, M. C., Rangel-Castilla, L., Levy, E. I., Snyder, K. V., Siddiqui, A. H. Tags: Ischemic stroke Source Type: research

The golden hour of stroke intervention: effect of thrombectomy procedural time in acute ischemic stroke on outcome
Conclusions Our findings suggest that extending mechanical thrombectomy procedure times beyond 60 min increases complications and device cost rates while worsening outcomes. These findings can serve as a time frame of when it is prudent to abort a failed thrombectomy case.
Source: Journal of NeuroInterventional Surgery - August 6, 2014 Category: Neurosurgery Authors: Spiotta, A. M., Vargas, J., Turner, R., Chaudry, M. I., Battenhouse, H., Turk, A. S. Tags: Ischemic stroke Source Type: research

Interhospital variation in reperfusion rates following endovascular treatment for acute ischemic stroke
Conclusions Reperfusion rates vary among hospitals, which may be related to differences in treatment protocols and patient characteristics. Additional studies are needed to identify all of the factors that underlie this variability as this could lead to strategies that reduce interhospital variability in reperfusion rates and improve clinical outcomes.
Source: Journal of NeuroInterventional Surgery - March 12, 2015 Category: Neurosurgery Authors: Liggins, J. T. P., Mlynash, M., Jovin, T. G., Straka, M., Kemp, S., Bammer, R., Marks, M. P., Albers, G. W., Lansberg, M. G., on behalf of the DEFUSE 2 Investigators Tags: Ischemic stroke Source Type: research

Venous imaging-based biomarkers in acute ischaemic stroke
Vascular neuroimaging plays a decisive role in selecting the best therapy in patients with acute ischaemic stroke. However, compared with the arterial system, the role of veins has not been thoroughly studied. In this review, we present the major venous imaging-based biomarkers in ischaemic stroke. First, the presence of hypodense veins in the monophasic CT angiography ipsilateral to the arterial occlusion. Second, the asymmetry of venous drainage in the pathological cerebral hemisphere on CT and MRI dynamic angiography. Finally, the presence of hypodense veins on T2* -based MRI. From the physiological point of view, the v...
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2016 Category: Neurosurgery Authors: Munuera, J., Blasco, G., Hernandez-Perez, M., Daunis-i-Estadella, P., Davalos, A., Liebeskind, D. S., Wintermark, M., Demchuk, A., Menon, B. K., Thomalla, G., Nael, K., Pedraza, S., Puig, J. Tags: Stroke, Radiology, Radiology (diagnostics) Cerebrovascular disease Source Type: research

Primary acute stroke thrombectomy within 3 h for large artery occlusion (PAST3-LAO): a pilot study
Conclusions Our study demonstrates that primary SRT in AIS from LAO is safe and feasible and is associated with complete recanalization and good outcome. Further study is required.
Source: Journal of NeuroInterventional Surgery - March 15, 2017 Category: Neurosurgery Authors: Lodi, Y., Reddy, V., Petro, G., Devasenapathy, A., Hourani, A., Chou, C.-A. Tags: Ischemic stroke Source Type: research

Endovascular thrombectomy beyond 24 hours from ischemic stroke onset: a propensity score matched cohort study
Conclusion In this real world study, EVT beyond 24 hours from stroke onset or last known well appeared to be feasible, with comparable safety and functional outcomes to EVT initiation between 6 and 24 hours. Randomized trials assessing the efficacy of EVT in the VL window are warranted, but may only be feasible with a large international collaborative approach.
Source: Journal of NeuroInterventional Surgery - February 14, 2023 Category: Neurosurgery Authors: Dhillon, P. S., Butt, W., Podlasek, A., Barrett, E., McConachie, N., Lenthall, R., Nair, S., Malik, L., James, M. A., Dineen, R. A., England, T. J. Tags: Ischemic stroke Source Type: research

Contrast conservation measures during the global iohexol contrast shortage crisis did not affect stroke thrombectomy outcomes
Conclusions Modifying stroke workflow to adapt to the current global shortage in iohexol is feasible. Using diluted iohexol (50% contrast mixed with 50% heparinized saline) did not affect MT outcomes.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Almallouhi, E., Sattur, M., Lajthia, O., Kicielinski, K. P., Holmstedt, C., Lena, J. R., Al Kasab, S., Spiotta, A. M. Tags: Ischemic stroke Source Type: research

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