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Source: Neuroscience Letters
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Total 79 results found since Jan 2013.
Dose-dependent effects of tetramethylpyrazine on the characteristics of human umbilical cord mesenchymal stem cells for stroke therapy
This study determined the dose-dependent effects of tetramethylpyrazine (TMP) on the characteristics of ucMSCs in vitro. The effect on proliferation was determined with Cell Counting kit-8 assays. Cell migration was analyzed with Transwell assays and western blot analysis. Differentiation of ucMSCs was evaluated according to markers and the expression of relevant proteins and genes. Secretion capacity was detected by ELISA analysis. TMP protected ucMSCs against H2O2 induced-oxidative damage but had no influence on ucMSC activity at a low concentration. Furthermore, ucMSC migration was improved by TMP via the SDF-1/CXCR4 ax...
Source: Neuroscience Letters - February 15, 2020 Category: Neuroscience Source Type: research
Motor Imagery Based Brain-Computer Interface Control of Continuous Passive Motion for Wrist Extension Recovery in Chronic Stroke Patients
Publication date: Available online 27 December 2019Source: Neuroscience LettersAuthor(s): Rong-Rong Lu, Mou-Xiong Zheng, Jie Li, Tian-Hao Gao, Xu-Yun Hua, Gang Liu, Song-Hua Huang, Jian-Guang Xu, Yi WuAbstractMotor recovery of wrist and fingers is still a great challenge for chronic stroke survivors. The present study aimed to verify the efficiency of motor imagery based brain-computer interface (BCI) control of continuous passive motion (CPM) in the recovery of wrist extension due to stroke. An observational study was conducted in 26 chronic stroke patients, aged 49.0 ± 15.4 years, with upper extremity motor impairme...
Source: Neuroscience Letters - December 28, 2019 Category: Neuroscience Source Type: research
Effects of the multisensory rehabilitation product for home-based hand training after stroke on cortical activation by using NIRS methods
ConclusionsAccording to these results, MFTOM-induced cortical activation in the MC, PFC and TL with visual, auditory and tactile stimuli was stronger than SFTOM, providing evidence that the multisensory stimulation is more beneficial to cortical activation and cognitive control to promote neurological recovery.
Source: Neuroscience Letters - December 17, 2019 Category: Neuroscience Source Type: research
Found in Translation: The Rationale Behind the Early Development of Glibenclamide in Large Hemispheric Infarction
Publication date: Available online 2 December 2019Source: Neuroscience LettersAuthor(s): Sven M. Jacobson, Thomas W. MacAllister, David M. GeliebterAbstractMany reasons have been put forth to explain the inability to translate neuroprotection in animal stroke models to humans. Following our determination that glibenclamide is an anti-edema drug, not a neuroprotective drug, and the revelation that the “gold standard” middle cerebral artery occlusion used for animal studies models large hemispheric infarction, a subpopulation of ischemic stroke that develops clinically relevant edema that contributes significantly to poo...
Source: Neuroscience Letters - December 4, 2019 Category: Neuroscience Source Type: research
Influence of unilateral spatial neglect on vertical perception in post-stroke pusher behavior
Publication date: Available online 30 November 2019Source: Neuroscience LettersAuthor(s): Kazuhiro Fukata, Kazu Amimoto, Yuji Fujino, Masahide Inoue, Mamiko Inoue, Yosuke Takahashi, Daisuke Sekine, Shigeru Makita, Hidetoshi TakahashiAbstractPusher behavior (PB) impairs verticality in the frontal plane and is often associated with unilateral spatial neglect (USN). However, it is unclear whether USN affects verticality among patients with PB. We aimed to clarify the characteristics of verticality among PB, with and without USN. The study included 43 patients with right hemisphere stroke, including 12 without PB or USN, 10 wi...
Source: Neuroscience Letters - December 1, 2019 Category: Neuroscience Source Type: research
Effects of mesencephalic astrocyte-derived neurotrophic factor on cerebral angiogenesis in a rat model of cerebral ischemia
In conclusion, our findings provide insight into the mechanisms of MANF in promoting functional recovery from ischemic stroke. Our results suggest that MANF improves neurobehavioral recovery from cerebral ischemic injury, and that this effect is mediated partly by its proangiogenic effects and augmentation of rCBF, which are possibly associated with VEGF.
Source: Neuroscience Letters - November 28, 2019 Category: Neuroscience Source Type: research
Micro RNA 181c-5p: a promising target for post-stroke recovery in socially isolated mice
Publication date: Available online 10 November 2019Source: Neuroscience LettersAuthor(s): Maria Antony, Victoria Scranton, Pranay Srivastava, Rajkumar VermaAbstractDysregulation of microRNAs (miRNAs) has been tied to several neurological disorders, including ischemic stroke. It has also been established that social environments can modulate miRNA profiles. We have previously shown that post-stroke social isolation (SI) is linked to poor stroke outcomes and that miR-181c-5p emerged as one of few lead miRNAs that was downregulated in both stroke and SI. Therefore, in this study we examined the potential role of miR-181c-5p m...
Source: Neuroscience Letters - November 11, 2019 Category: Neuroscience Source Type: research
Phasic GABA signaling mediates the protective effects of cTBS against cerebral ischemia in mice
Publication date: Available online 4 November 2019Source: Neuroscience LettersAuthor(s): Yi-wei Feng, Yi-qing Huang, Ying Yan, Ge Li, Xiao-fei He, Feng-yin Liang, Zhong Pei, Yue Lan, Guang-qing XuAbstractContinuous theta burst stimulation (cTBS) has been widely recognized as a therapeutic treatment for ischemic stroke, but the underlying mechanism is still elusive. Here, we investigated the protective effects of cTBS in the posterior parietal cortex during the chronic phase of stroke in the photothrombotic ischemic model. Infarction volume and neuron excitability in the peri-infarct area were assessed using immunohistochem...
Source: Neuroscience Letters - November 5, 2019 Category: Neuroscience Source Type: research
Circulating Aquaporin-4 as a biomarker of early neurological improvement in stroke patients: a pilot study
Publication date: Available online 28 October 2019Source: Neuroscience LettersAuthor(s): Laura Ramiro, Alba Simats, Anna Penalba, Alvaro Garcia-Tornel, Alex Rovira, Fernando Mancha, Alejandro Bustamante, Joan MontanerAbstractPatients’ outcome prediction after ischemic stroke is still challenging. Aquaporin-4 (AQP4) is a water channel that is up-regulated in the brain after the ischemic event, but its presence in bloodstream of stroke patients has not been previously studied. The aim of this pilot study was to investigate circulating AQP4 levels after stroke and its correlation with infarct growth and neurological outcome...
Source: Neuroscience Letters - October 30, 2019 Category: Neuroscience Source Type: research
Visual processing features in patients with visual spatial neglect recovering from right-hemispheric stroke
ConclusionsOur findings support the use of the event-related potential as a tool for investigating rapid recovery from VSN after stroke and suggest that other factors, such as an asymmetrical omission toward the contralateral side or impairment in the temporal processing capacity, might also be potential biomarkers of recovery.
Source: Neuroscience Letters - October 2, 2019 Category: Neuroscience Source Type: research
Establishment of optimal two-point discrimination test method and consideration of reproducibility
Publication date: Available online 30 September 2019Source: Neuroscience LettersAuthor(s): Hirotake Yokota, Naofumi Otsuru, Rie Kikuchi, Rinako Suzuki, Sho Kojima, Kei Saito, Shota Miyaguchi, Yasuto Inukai, Hideaki OnishiAbstractTwo-point discrimination (TPD) has been widely used as a parameter for the examination of higher-order perceptual functions in the field of rehabilitation. Previous research has shown that the threshold of TPD increases with aging or pathological conditions such as stroke or chronic pain. It has also been reported that the threshold can be decreased by continuous tactile or electrical stimulation. ...
Source: Neuroscience Letters - October 1, 2019 Category: Neuroscience Source Type: research
Revealing sex-specific molecular changes in hypoxia-ischemia induced neural damage and subsequent recovery using zebrafish model
Publication date: Available online 10 September 2019Source: Neuroscience LettersAuthor(s): Tapatee Das, Kalyani Soren, Mounica Yerasi, Arvind Kumar, Sumana ChakravartyAbstractFunctional recovery from hypoxia-ischemia depends on an individual’s response to the ischemic damage and recovery. Many of the neurological disorders, including cerebral stroke have sex-specific characteristics. Deciphering the differential molecular mechanisms of sex-specific recovery from hypoxic-ischemic insult can improve medical practice in the treatment of cerebral stroke. In the present study, we describe the establishment of a sex-specific g...
Source: Neuroscience Letters - September 12, 2019 Category: Neuroscience Source Type: research
Influence of positional changes on spasticity of the upper extremity in poststroke hemiplegic patients
ConclusionHigh modulation of spasticity in the upper limbs measured using the MAS, MTS and TSS when transitioning to the standing position from either the supine or sitting position demonstrated that posture plays a role in modulating the spasticity of the hemiplegic upper limb in poststroke patients.
Source: Neuroscience Letters - September 4, 2019 Category: Neuroscience Source Type: research
Simultaneous alterations of oligodendrocyte-specific CNP, astrocyte-specific AQP4 and neuronal NF-L demarcate ischemic tissue after experimental stroke in mice
In conclusion, the present study provides evidence for a simultaneous affection of oligodendrocytes, astrocytes and neurons after experimental focal cerebral ischemia. Consequently, CNP, AQP4 and NF-L immunofluorescence alterations can be utilized to identify ischemia-affected tissue. The simultaneity of the described alterations further strengthens the concept of interdependent NVU components and distinguishes NF-L, CNP and AQP4 as highly ischemia-sensitive elements. Consequently, future therapeutic approaches might influence stroke evolution via strategies simultaneously addressing both neuronal and glial functions.
Source: Neuroscience Letters - July 31, 2019 Category: Neuroscience Source Type: research
Plasma levels of matrix metalloproteinase-9: A possible marker for cold-induced stroke risk in hypertensive rats
Publication date: Available online 23 July 2019Source: Neuroscience LettersAuthor(s): Huanmin Li, Peijian Yue, Yuying Su, Chunguang LiAbstractThe cold weather is associated with an increased occurrence of acute stroke events. However, the underlying mechanisms have not yet been fully elucidated. In the present study, we investigated whether plasma matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels as well as the MMP-9/TIMP-1 ratio could be used as predictor for cold-induced stroke risk in hypertensive rats. A total of 50 male rats were subjected to either control group or 2-kidne...
Source: Neuroscience Letters - July 24, 2019 Category: Neuroscience Source Type: research
