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Source: Journal of Neurochemistry
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Total 69 results found since Jan 2013.
Dense dopaminergic innervation of the peri ‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats
In this study, we assessed the reorganization of dopaminergic innervation of the PIC in a rat model of focal cortical stroke. Our data suggest a sprouting of dopaminergic fibers into the PIC and point to a role for dopaminergic signaling in reparative mechanisms post-stroke, potentially related to recovery. AbstractAfter ischemic stroke, the cortex directly adjacent to the ischemic core (i.e., the peri-infarct cortex, PIC) undergoes plastic changes that facilitate motor recovery. Dopaminergic signaling is thought to support this process. However, ischemic stroke also leads to the remote degeneration of dopaminergic midbrai...
Source: Journal of Neurochemistry - September 22, 2023 Category: Neuroscience Authors: Sibylle Frase,
Julius Steddin,
Enya Paschen,
Maximilian Lenz,
Pasquale Conforti,
Carola A. Haas,
Andreas Vlachos,
Christian Schachtrup,
Jonas A. Hosp Tags: ORIGINAL ARTICLE Source Type: research
Ketamine improves neuronal recovery following spreading depolarization in peri ‐infarct tissues
We examined spreading depolarization (SD) waves in a mouse stroke model. SDs were initiated by focal potassium chloride application and propagated through a region of graded perfusion deficit created by distal middle cerebral artery (dMCA) occlusion. Longer lasting depolarizations (DC shifts measured from local field potential (LFP) electrodes) and neuronal Ca2+ transients (epifluorescence GCaMP imaging) occurred at locations with larger perfusion deficits (proximal to occlusion), as compared with remote recording sites (laser speckle contrast imaging (LSCI) of cerebral perfusion). Ketamine, at concentrations that did not ...
Source: Journal of Neurochemistry - August 19, 2023 Category: Neuroscience Authors: Katelyn M. Reinhart,
Russell A. Morton,
K. C. Brennan,
Andrew P. Carlson,
C. William Shuttleworth Tags: ORIGINAL ARTICLE Source Type: research
Gene expression profiling in whole blood stimulated ex vivo with lipopolysaccharide as a tool to predict post ‐stroke depressive symptoms: Proof‐of‐concept study
We studied if blood gene expression could facilitate identification of persons who will develop depression 3 months after ischemic stroke. Venous blood samples were collected on day 3 after stroke. Obtained blood was stimulated in vitro with lipopolysaccharide, a powerful inducer of gene expression. After stimulation, RNA was isolated and sequenced. Expression of 510 genes differed between patients who developed depression and those who had not depression after stroke. Bioinformatic analysis revealed that expression of 6 genes (PKM, PRRC2C, NUP188, CHMP3, H2AC8, NOP10) accurately predicted a risk of depression. Our finding...
Source: Journal of Neurochemistry - June 27, 2023 Category: Neuroscience Authors: Marcin Piechota,
Dzesika Hoinkis,
Michal Korostynski,
Slawomir Golda,
Joanna Pera,
Tomasz Dziedzic Tags: ORIGINAL ARTICLE Source Type: research
Toll ‐like receptor 4‐mediated microglial inflammation exacerbates early white matter injury following experimental subarachnoid hemorrhage
In conclusion, microglial inflammation has dual effects on early WMI after experimental SAH. Future explorations on more clinically relevant methods for modulating neuroinflammation are warranted to combat stroke with both WMI and gray matter destruction.
Source: Journal of Neurochemistry - June 13, 2023 Category: Neuroscience Authors: Jianhua Peng,
Yuke Xie,
Jinwei Pang,
Yue Wu,
Jian Zhou,
Long Gu,
Kecheng Guo,
Lifang Zhang,
Bingqing Xie,
Shigang Yin,
Xiaochuan Sun,
Ligang Chen,
Yong Jiang Tags: ORIGINAL ARTICLE Source Type: research
Astragaloside IV alleviates neuronal ferroptosis in ischemic stroke by regulating fat mass and obesity ‐associated—N6‐methyladenosine—acyl‐CoA synthetase long‐chain family member 4 axis
Ischemic stroke (IS) is a detrimental neurological disease with limited treatments options. Astragaloside IV (As-IV) was a promising bioactive constituent in the treatment of IS. In our study, As-IV promoted the transcription of fat mass and obesity-associated (Fto) by upregulating activating transcription factor 3(Atf3), resulting in a decrease of long-chain acyl-CoA synthetase-4 (Acsl4) N6-methyladenosine (m6A) levels, thus improving neuronal injury in IS by inhibiting ferroptosis. These findings provided a better understanding of the molecular mechanisms underlying the neuroprotective effects of As-IV and led to novel t...
Source: Journal of Neurochemistry - June 10, 2023 Category: Neuroscience Authors: Zhenglong Jin,
Wenying Gao,
Fu Guo,
Shaojun Liao,
Mingzhe Hu,
Tao Yu,
Shangzhen Yu,
Qing Shi Tags: ORIGINAL ARTICLE Source Type: research
Bioinformatics ‐based analysis of mechanistic differences in vascular endothelial injury ischemic stroke induced by atrial fibrillation and atherosclerosis
This study aimed to investigate the mechanistic differences in endothelial injury between atrial fibrillation (AF)- and AS-induced ischemic stroke. All target genes of AF, AS, and the vascular endothelial cell (VC) were obtained from the GeneCards database; the differential genes of AF and AS separately associated with the VC were established by a Venn diagram. A protein –protein interaction network was created, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases were used to perform genomic enrichment and functional enrichment analysis. Hub genes were selected by Maximal Clique Centrality algorithm r...
Source: Journal of Neurochemistry - June 2, 2023 Category: Neuroscience Authors: Jia Li,
Rui Yang,
Shenglin Wang,
Ziyi Shen,
Bowen Wu,
Yu Ren,
Sha Ke,
Guohui Jiang Tags: ORIGINAL ARTICLE Source Type: research
Associations of circulating metabolites with cerebral white matter hyperintensities
This study found that the majority of lipoprotein subclasses and lipid concentration are strongly associated with WMH volume, and several non-lipid-related traits such as Gly, MUFA, and degree of unsaturation present certain effects on WMH. In addition, the results revealed the sex and age specificities indicating the distinct metabolomic features impact WMH in diverse individuals. These results demonstrated the power of detailed metabolite profiling for biomarker discovery, which can yield an improved molecular understanding of disease mechanisms. AbstractWhite matter hyperintensities (WMH) are the most compelling risk fa...
Source: Journal of Neurochemistry - May 25, 2023 Category: Neuroscience Authors: Yan Sun,
Yu Guo,
Hong ‐Qi Li,
Lan Tan,
Jian‐Feng Feng,
Wei Cheng,
Jin‐Tai Yu Tags: ORIGINAL ARTICLE Source Type: research
Ca2+ ‐dependent activator protein for secretion 1 promotes spontaneous recovery in ischemic stroke by regulating BDNF secretion
In conclusion, CAPS1 regulates neurogenesis by upregulating BDNF release in the hippocampus, which finally facilitate spontaneous recovery after ischemic stroke.
Source: Journal of Neurochemistry - March 15, 2023 Category: Neuroscience Authors: DianWei Liu,
Yan Zheng,
Yuan Chen,
Yang Jiang,
HuiYun Wang,
LingMei Li,
Ling Ma Tags: ORIGINAL ARTICLE Source Type: research
High ‐frequency repetitive magnetic stimulation rescues ischemia‐injured neurons through modulation of glial‐derived neurotrophic factor present in the astrocyte's secretome
This study aims to identify the effects triggered by high-frequency repetitive magnetic stimulation (HF-rMS) on astrocytes that contribute to its neuroprotective effects. Neuron-glia and astrocyte cortical cultures subject to oxygen and glucose deprivation were used as an in vitro model of ischemia. Neuroprotection promoted by HF-rMS was evaluated by analysis of markers of neuronal activity and morphometric analysis of neurons. Glial reactivity was determined by immunocytochemistry. The levels of growth factors in the astrocyte conditioned medium (CM) were assessed through a Growth Factor Array and glial-derived neurotroph...
Source: Journal of Neurochemistry - December 7, 2022 Category: Neuroscience Authors: Genilso Gava ‐Junior,
Susana A. Ferreira,
Cláudio Roque,
Julieta Mendes‐Oliveira,
Inês Serrenho,
Nuno Pinto,
Maria Vaz Patto,
Graça Baltazar Tags: ORIGINAL ARTICLE Source Type: research
Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex, and Parkinson's disease ‐related changes
Transfer RNA fragments (tRFs) are important regulatory small RNAs with diverse functions. We studied age, sex, and Parkinson's disease (PD) effects on the distributions of tRFs in the cerebrospinal fluid (CSF) and blood, in NIH and PPMI datasets. We discovered that CSF tRFs were more variable in length and cleavage subtypes, negatively correlated with age and showed more pronounced differences between males and females than blood tRFs. Both CSF and blood tRFs differentiated PD patients from controls, based on distinct subsets of tRFs, both highly enriched with mitochondrial Cholino-tRFs. Our findings point at tRFs as a pro...
Source: Journal of Neurochemistry - November 23, 2022 Category: Neuroscience Authors: Iddo Paldor,
Nimrod Madrer,
Shani Vaknine Treidel,
Dana Shulman,
David S. Greenberg,
Hermona Soreq Tags: ORIGINAL ARTICLE Source Type: research
Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex and Parkinson's disease ‐related changes
AbstractTransfer RNA fragments (tRFs) have recently been shown to be an important family of small regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood levels in a number of nervous system conditions including epilepsy, ischemic stroke and neurodegenerative diseases, but little is known about tRF levels in the cerebrospinal fluid (CSF). To address this issue, we studied age, sex and Parkinson's disease (PD) effects on the distributions of tRFs in the CSF and blood data of healthy controls and PD patients from the NIH and the Parkinson's Progression Markers Initiative (PPMI) small RNA-seq d...
Source: Journal of Neurochemistry - November 11, 2022 Category: Neuroscience Authors: Iddo Paldor,
Nimrod Madrer,
Shani Vaknine Treidel,
Dana Shulman,
David S. Greenberg,
Hermona Soreq Tags: ORIGINAL ARTICLE Source Type: research
Inhibition of interaction between ROCK1 and Rubicon restores autophagy in endothelial cells and attenuates brain injury after prolonged ischemia
AbstractAbstractAcute ischemic stroke (AIS) induces cerebral endothelial cells death resulting in the breakdown of blood-brain barrier (BBB). Endothelial cells autophagy acts as a protective mechanism against cell death. Autophagy is activated in the very early stages of ischemic stroke and declines after prolonged ischemia. Previous studies have shown that Rubicon can inhibit autophagy. The current study aimed to investigate whether continuous long-term ischemia can inhibit autophagy in endothelial cells after ischemic stroke by regulating the function of Rubicon and its underlying mechanism.Wild-type male C57BL/6J mice w...
Source: Journal of Neurochemistry - November 6, 2022 Category: Neuroscience Authors: Yinyao Lin,
Zexin Zhan,
Mengyan Hu,
Haiyan Li,
Bingjun Zhang,
Ruizhen Wu,
Sha Tan,
Yilong Shan,
Zhengqi Lu,
Bing Qin Tags: ORIGINAL ARTICLE Source Type: research
LncRNA nuclear ‐enriched abundant transcript 1 aggravates cerebral ischemia/reperfusion injury through activating early growth response‐1/RNA binding motif protein 25 axis
In conclusion, this work identified a novel NEAT1/EGR1/RBM25 axis in potentiating brain injury after IR insults, suggesting a potential therapeutic target for ischemic stroke.
Source: Journal of Neurochemistry - August 23, 2022 Category: Neuroscience Authors: Jing ‐Wei Cao,
Zhan‐Bin Tang,
Ji‐Wei Zhao,
Jing‐Kun Zhao,
Jia‐Lin Yao,
Xiao‐Meng Sheng,
Mian‐Qiao Zhao,
Qiong Duan,
Bai‐Chao Han,
Shu‐Rong Duan Tags: ORIGINAL ARTICLE Source Type: research
Sphingosine ‐1‐phosphate receptor modulators in stroke treatment
AbstractSphingosine-1-phosphate (S1P) is a bioactive lysophospholipid that can influence a broad range of biological processes through its binding to five distinct G protein-coupled receptors. S1P receptor modulators are a new group of immunosuppressive agents currently used in the immunotherapy of multiple sclerosis. Inflammation following stroke may exacerbate injury. Given that S1P signaling is linked to multiple immune processes, therapies targeting the S1P axis may be suitable for treating stroke. In this review, we outline S1P metabolism and S1P receptors, discuss the mechanisms of action of S1P receptor modulators i...
Source: Journal of Neurochemistry - August 9, 2022 Category: Neuroscience Authors: Wanzhou Zhang,
Yudi Li,
Fangming Li,
Li Ling Tags: REVIEW Source Type: research
Circulating metabolites associated with incident myocardial infarction and stroke: a prospective cohort study of 90,438 participants
AbstractThe relevance between circulating metabolites and vascular events remains controversial and comprehensive studies are lacking. We sought to investigate the prospective associations of plasma metabolomics with risks of incident stroke, ischemic stroke (IS), hemorrhagic stroke (HS) and myocardial infarction (MI). Within the UK Biobank cohort, 249 circulating metabolites were measured in 90,438 participants without baseline vascular diseases. Cox proportional hazards regressions were applied to estimate adjusted hazard ratios (HRs) for per 1 standard deviation increment in metabolites. The least absolute shrinkage and...
Source: Journal of Neurochemistry - June 28, 2022 Category: Neuroscience Authors: Yu Guo,
Shu ‐Fen Chen,
Ya‐Ru Zhang,
Hui‐Fu Wang,
Shu‐Yi Huang,
Shi‐Dong Chen,
Yue‐Ting Deng,
Bang‐Sheng Wu,
Kevin Kuo,
Rong‐Ze Wang,
Qiang Dong,
Jian‐Feng Feng,
Wei Cheng,
Jin‐Tai Yu Tags: ORIGINAL ARTICLE Source Type: research
