• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes.
Abstract The past 3 decades have been characterized by an exponential growth in knowledge and advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis requires a vulnerable atrial substrate and that the formation and composition of this substrate may vary depending on comorbid conditions, genetics, sex, and other factors. Population-based studies have identified numerous factors that modify the atrial substrate and increase AF susceptibility. To date, genetic studies have reported 17 independent signals for AF at 14 genomic regions. Studies have established that advanced age,...
Source: Circulation Research - April 28, 2017 Category: Cardiology Authors: Staerk L, Sherer JA, Ko D, Benjamin EJ, Helm RH Tags: Circ Res Source Type: research

Cardiovascular Event Prediction by Machine Learning: The Multi-Ethnic Study of Atherosclerosis.
Conclusions: Machine learning in conjunction with deep phenotyping improve prediction accuracy in cardiovascular event prediction in an initially asymptomatic population. These methods may lead to greater insights regarding subclinical disease markers without apriori assumptions of causality. PMID: 28794054 [PubMed - as supplied by publisher]
Source: Circulation Research - August 9, 2017 Category: Cardiology Authors: Ambale-Venkatesh B, Yang X, Wu CO, Liu K, Hundley WG, McClelland RL, Gomes AS, Folsom AR, Shea S, Guallar E, Bluemke DA, Lima JA Tags: Circ Res Source Type: research

Thyroid Function and the Risk of Atherosclerotic Cardiovascular Morbidity and Mortality: The Rotterdam Study.
Conclusions: FT4 levels in middle-aged and elderly subjects were positively associated with atherosclerosis throughout the whole disease spectrum, independently of cardiovascular risk factors. PMID: 29089349 [PubMed - as supplied by publisher]
Source: Circulation Research - October 31, 2017 Category: Cardiology Authors: Bano A, Chaker L, Mattace-Raso FU, van der Lugt A, Ikram MA, Franco OH, Peeters RP, Kavousi M Tags: Circ Res Source Type: research

Safety and Efficacy of Intracoronary Infusion of Allogeneic Human Cardiac Stem Cells in Patients with ST-segment Elevation Myocardial Infarction and Left Ventricular Dysfunction: A Multicenter Randomized, Double-Blind and Placebo-Controlled Clinical Trial.
Conclusions: Allogeneic cardiac stem cells can be safely administered in STEMI patients with LV dysfunction early after revascularization. Low immunogenicity and absence of immune-mediated events will facilitate adequately powered studies to demonstrate their clinical efficacy in this setting.Clinical Trial Registration: NCT 02439398. PMID: 29921651 [PubMed - as supplied by publisher]
Source: Circulation Research - June 19, 2018 Category: Cardiology Authors: Fernández-Avilés F, Sanz-Ruiz R, Bogaert J, Casado Plasencia A, Gilaberte I, Belmans A, Fernández-Santos ME, Charron D, Mulet M, Yotti R, Palacios I, Luque M, Sádaba R, San Roman JA, Larman M, Sánchez PL, Sanchis J, Jimenez-Navarro MF, Claus P, Al-Da Tags: Circ Res Source Type: research

The Mediterranean Diet and Cardiovascular Health.
Abstract The Mediterranean diet (MedDiet), abundant in minimally processed plant-based foods, rich in monounsaturated fat from olive oil, but lower in saturated fat, meats, and dairy products, seems an ideal nutritional model for cardiovascular health. Methodological aspects of Mediterranean intervention trials, limitations in the quality of some meta-analyses, and other issues may have raised recent controversies. It remains unclear whether such limitations are important enough as to attenuate the postulated cardiovascular benefits of the MedDiet. We aimed to critically review current evidence on the role of the ...
Source: Circulation Research - February 28, 2019 Category: Cardiology Authors: Martínez-González MA, Gea A, Ruiz-Canela M Tags: Circ Res Source Type: research

Relationship Between Serum Alpha-Tocopherol and Overall and Cause-Specific Mortality.
CONCLUSIONS: In this long-term prospective cohort study, higher baseline serum α-tocopherol biochemical status was associated with lower risk of overall mortality and mortality from all major causes. Our data support the long-term health benefits of higher serum α-tocopherol for overall and chronic disease mortality and should be replicated in other more diverse populations. PMID: 31219752 [PubMed - in process]
Source: Circulation Research - June 20, 2019 Category: Cardiology Authors: Huang J, Weinstein SJ, Yu K, Männistö S, Albanes D Tags: Circ Res Source Type: research

Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa Driven Platelet Activation Via Protease Activated Receptor-1.
Conclusions: Here we identified FXa as potent platelet agonist that acts through PAR1. Therefore, RIVA exerts an antiplatelet effect that together with its well-known potent anticoagulatory capacity might lead to reduced frequency of atherothrombotic events and improved outcome in patients. PMID: 31859592 [PubMed - as supplied by publisher]
Source: Circulation Research - December 19, 2019 Category: Cardiology Authors: Petzold T, Thienel M, Dannenberg LK, Mourikis P, Helten C, Ayhan A, M'Pembele R, Achilles A, Trojovsky K, Konsek D, Zang Z, Regenauer R, Pircher J, Ehrlich A, Lüsebrink E, Nicolai L, Stocker T, Brandl R, Röschentaler F, Strecker J, Saleh I, Spannagl M, Tags: Circ Res Source Type: research

Hematopoiesis and Cardiovascular Disease.
Abstract A central feature of atherosclerosis, the most prevalent chronic vascular disease and root cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall. These crucial immune cells are produced in specialized niches in the bone marrow, where a complex cell network orchestrates their production and release. A growing body of clinical studies has documented a correlation between leukocyte numbers and cardiovascular disease risk. Understanding how leukocytes are produced and how they contribute to atherosclerosis and its complications is, therefore, critical to understanding and t...
Source: Circulation Research - April 9, 2020 Category: Cardiology Authors: Poller WC, Nahrendorf M, Swirski FK Tags: Circ Res Source Type: research

Sex as a Biological Variable in Atherosclerosis.
This article reviews the available data. Overall, male animals appear to have more inflamed yet smaller plaques compared to female animals. Plaque inflammation is often used as a surrogate end point for plaque vulnerability in animals. The available data support the notion that rather than plaque size, plaque inflammation may be more relevant in assessing sex-specific mechanisms since the findings correlate with the sex difference in ischemic events and mortality and thus may be more reflective of the human condition. Overall, the number of preclinical studies directly comparing plaque inflammation between the sexes is ext...
Source: Circulation Research - April 23, 2020 Category: Cardiology Authors: Man JJ, Beckman JA, Jaffe IZ Tags: Circ Res Source Type: research

Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.
Conclusions: Our findings identify HDAC9 as a regulator of atherosclerotic plaque stability and IKK activation thus providing a mechanistic explanation for the prominence of HDAC9 as a vascular risk locus in genome-wide association studies. Its therapeutic inhibition may provide a potent lever to alleviate vascular inflammation. PMID: 32546048 [PubMed - as supplied by publisher]
Source: Circulation Research - June 16, 2020 Category: Cardiology Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RT, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, D Tags: Circ Res Source Type: research

MiR-18a inhibits BMP4 and HIF-1 α Normalizing Brain Arteriovenous Malformations.
Conclusions: MiR-18a may have significant clinical value in preventing, reducing and potentially reversing AVM. PMID: 32755283 [PubMed - as supplied by publisher]
Source: Circulation Research - August 4, 2020 Category: Cardiology Authors: Marín-Ramos NI, Thein TZ, Ghaghada KB, Chen TC, Giannotta SL, Hofman F Tags: Circ Res Source Type: research

New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease
Circ Res. 2021 Jun 11;128(12):1944-1957. doi: 10.1161/CIRCRESAHA.121.318266. Epub 2021 Jun 10.ABSTRACTThe prevalence of peripheral arterial disease (PAD) in the United States exceeds 10 million people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is typically caused by atherosclerotic obstructions in the large arteries to the leg(s). The most common clinical consequences of PAD include pain on walking (claudication), impaired functional capacity, pain at rest, and loss of tissue integrity in the distal limbs that may lead to lower extremity amputation. Patients with PAD also have higher t...
Source: Circulation Research - June 10, 2021 Category: Cardiology Authors: Brian H Annex John P Cooke Source Type: research

FMD and SCAD: Sex-Biased Arterial Diseases With Clinical and Genetic Pleiotropy
Circ Res. 2021 Jun 11;128(12):1958-1972. doi: 10.1161/CIRCRESAHA.121.318300. Epub 2021 Jun 10.ABSTRACTMultifocal fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection are both sex-biased diseases disproportionately affecting women over men in a 9:1 ratio. Traditionally known in the context of renovascular hypertension, recent advances in knowledge about FMD have demonstrated that FMD is a systemic arteriopathy presenting as arterial stenosis, aneurysm, and dissection in virtually any arterial bed. FMD is also characterized by major cardiovascular presentations including hypertension, stroke, and myocardi...
Source: Circulation Research - June 10, 2021 Category: Cardiology Authors: Esther S H Kim Jacqueline Saw Daniella Kadian-Dodov Malissa Wood Santhi K Ganesh Source Type: research

Cerebral Cavernous Malformation: From Mechanism to Therapy
Circ Res. 2021 Jun 25;129(1):195-215. doi: 10.1161/CIRCRESAHA.121.318174. Epub 2021 Jun 24.ABSTRACTCerebral cavernous malformations are acquired vascular anomalies that constitute a common cause of central nervous system hemorrhage and stroke. The past 2 decades have seen a remarkable increase in our understanding of the pathogenesis of this vascular disease. This new knowledge spans genetic causes of sporadic and familial forms of the disease, molecular signaling changes in vascular endothelial cells that underlie the disease, unexpectedly strong environmental effects on disease pathogenesis, and drivers of disease end po...
Source: Circulation Research - June 24, 2021 Category: Cardiology Authors: Daniel A Snellings Courtney C Hong Aileen A Ren Miguel A Lopez-Ramirez Romuald Girard Abhinav Srinath Douglas A Marchuk Mark H Ginsberg Issam A Awad Mark L Kahn Source Type: research

Pages: 1  2  3  4  5  6