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Specialty: Neurology
Source: Stroke
Education: Study
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Total 1821 results found since Jan 2013.
Magnetic Resonance Imaging Selection for Endovascular Stroke Therapy Clinical Sciences
Conclusions—Workflow in GOLIATH demonstrates that magnetic resonance imaging selection for endovascular therapy can be accomplished rapidly and within a similar time frame as computed tomography-based selection.Clinical Trial Registration—URL: https://www.clinicaltrials.gov. Unique identifier: NCT02317237.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Claus Z. Simonsen, Albert J. Yoo, Mads Rasmussen, Kristina E. Sorensen, Thabele Leslie–Mazwi, Grethe Andersen, Leif H. Sorensen Tags: Magnetic Resonance Imaging (MRI), Revascularization, Ischemic Stroke Original Contributions Source Type: research
Clinical Utility of Electronic Alberta Stroke Program Early Computed Tomography Score Software in the ENCHANTED Trial Database Clinical Sciences
Background and Purpose—Clinical utility of electronic Alberta Stroke Program Early CT Score (e-ASPECTS), an automated system for quantifying signs of infarction, was evaluated in a large database of thrombolyzed patients with acute ischemic stroke.Methods—All baseline noncontrast computed tomographic scans of patients with anterior circulation acute ischemic stroke who participated in the alteplase dose arm of the randomized controlled trial ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) were reviewed; poor quality and large (>6 mm) slice thickness were excluded. Included scans had e-ASPECTS...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Simon Nagel, Xia Wang, Cheryl Carcel, Thompson Robinson, Richard I. Lindley, John Chalmers, Craig S. Anderson Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Antiplatelet Treatment After Transient Ischemic Attack and Ischemic Stroke in Patients With Cerebral Microbleeds in 2 Large Cohorts and an Updated Systematic Review Clinical Sciences
Background and Purpose—In patients with transient ischemic attack/ischemic stroke, microbleed burden predicts intracerebral hemorrhage (ICH), and ischemic stroke, but implications for antiplatelet treatment are uncertain. Previous cohort studies have had insufficient follow-up to assess the time course of risks, have not stratified risks by antithrombotic use, and have not reported extracranial bleeds or functional outcome of ICH versus ischemic stroke.Methods—In 2 independent prospective cohorts with transient ischemic attack/ischemic stroke (Oxford Vascular Study/mainly white; University of Hong Kong/mainly Chinese),...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Kui Kai Lau, Caroline E. Lovelock, Linxin Li, Michela Simoni, Sergei Gutnikov, Wilhelm Kuker, Henry Ka Fung Mak, Peter M. Rothwell Tags: Magnetic Resonance Imaging (MRI), Intracranial Hemorrhage, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Association of Blood Pressure With Short- and Long-Term Functional Outcome After Stroke Thrombectomy Clinical Sciences
This study aims to assess the association of BP changes during general anesthesia versus conscious sedation with functional outcome after mechanical thrombectomy.Methods—SIESTA (Sedation vs Intubation for Endovascular Stroke Treatment) was a monocentric randomized trial of general anesthesia versus conscious sedation during mechanical thrombectomy involving BP target protocols. In this post hoc analysis, BP measurements were divided into 4 phases: preintervention, prerecanalization, postrecanalization, and postintervention. We examined the association between BP and functional outcomes (defined by improvement of 24-hour ...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Silvia Schonenberger, Lorenz Uhlmann, Matthias Ungerer, Johannes Pfaff, Simon Nagel, Christina Klose, Martin Bendszus, Wolfgang Wick, Peter A. Ringleb, Meinhard Kieser, Markus A. Mohlenbruch, Julian Bosel Tags: Ischemic Stroke Original Contributions Source Type: research
Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury Basic Sciences
Conclusions—Our findings suggest that brain ischemia activates and diversifies T-cell responses locally, which exacerbates ischemic brain injury.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Wei-Na Jin, Rayna Gonzales, Yan Feng, Kristofer Wood, Zhi Chai, Jing-Fei Dong, Antonio La Cava, Fu-Dong Shi, Qiang Liu Tags: Ischemic Stroke Original Contributions Source Type: research
Role of Myeloid Lineage Cell Autophagy in Ischemic Brain Injury Basic Sciences
In this study, we investigated the roles of myeloid cell autophagy in ischemic brain injury.Methods—Focal cerebral ischemia was induced via transient middle cerebral artery occlusion in mice with autophagy-deficient myeloid lineage cells (Atg5flox/flox LysMCre+) and in their littermate controls (Atg5flox/flox). Infarct volume, neurological function, inflammatory cell infiltration, and proinflammatory cytokine expression levels were evaluated.Results—Mice lacking autophagy in myeloid lineage cells had a lower survival rate for 14 days than control mice (20% versus 70%; P
Source: Stroke - May 25, 2018 Category: Neurology Authors: Masakazu Kotoda, Hajime Furukawa, Takeshi Miyamoto, Masaaki Korai, Fumiaki Shikata, Atsushi Kuwabara, Xiaoxing Xiong, Caleb Rutledge, Rona G. Giffard, Tomoki Hashimoto Tags: Cerebral Aneurysm, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Synergistic Effects of Enriched Environment and Task-Specific Reach Training on Poststroke Recovery of Motor Function Basic Sciences
Conclusions—Task-specific reach training and environmental enrichment have synergistic effects in rats that persist long after rehabilitation ends, and this recovery is predicted by infarct volume and rehabilitation intensity.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Matthew Strider Jeffers, Dale Corbett Tags: Animal Models of Human Disease, Rehabilitation, Ischemic Stroke Original Contributions Source Type: research
Misdiagnosis of Cerebral Vein Thrombosis in the Emergency Department Brief Report
Conclusions—In a large, heterogeneous multistate cohort, probable misdiagnosis of CVT occurred in 1 of 30 patients but was not associated with the adverse clinical outcomes included in our study.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Ava L. Liberman, Gino Gialdini, Ekaterina Bakradze, Abhinaba Chatterjee, Hooman Kamel, Alexander E. Merkler Tags: Quality and Outcomes, Thrombosis Brief Reports Source Type: research
Combining Spot Sign and Intracerebral Hemorrhage Score to Estimate Functional Outcome Brief Report
Conclusions—In the PREDICT cohort, a prognostic score adding the computed tomographic angiography–based spot sign to the established ICH score did not improve functional outcome prediction compared with the ICH score.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Hauke Schneider, Thien J. Huynh, Andrew M. Demchuk, Dar Dowlatshahi, David Rodriguez-Luna, Yolanda Silva, Richard Aviv, Imanuel Dzialowski Tags: Computerized Tomography (CT), Imaging, Prognosis, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Brief Reports Source Type: research
Innovative Magnetic Resonance Imaging Markers of Hereditary Cerebral Amyloid Angiopathy at 7 Tesla Brief Report
Background and Purpose—The aim of the present study is to explore whether using 7 Tesla magnetic resonance imaging, additional brain changes can be observed in hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) patients as compared with the established magnetic resonance imaging features of sporadic cerebral amyloid angiopathy.Methods—The local institutional review board approved this prospective cohort study. In all cases, informed consent was obtained. This prospective parallel cohort study was conducted between 2012 and 2014. We performed T2*-weighted magnetic resonance imaging performed at 7 Tesla...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Emma A. Koemans, Ellis S. van Etten, Anna M. van Opstal, Gerda Labadie, Gisela M. Terwindt, Marieke J.H. Wermer, Andrew G. Webb, Edip M. Gurol, Steven M. Greenberg, Mark A. van Buchem, Jeroen van der Grond, Sanneke van Rooden Tags: Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Vascular Disease Brief Reports Source Type: research
Shorter Intensive Care Unit Stays? Brief Report
Conclusions—sICH associated with the administration of intravenous tPA typically occurs within the first 12 hours of treatment. Longer monitoring in an intensive care unit-like setting may be unnecessary for most individuals.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Adam Chang, Edward J. Llinas, Karen Chen, Rafael H. Llinas, Elisabeth B. Marsh Tags: Cerebrovascular Disease/Stroke Brief Reports Source Type: research
Time to Decision and Treatment With tPA (Tissue-Type Plasminogen Activator) Using Telemedicine Versus an Onboard Neurologist on a Mobile Stroke Unit Brief Report
Conclusions—Assessment by a TM-VN is comparable with an OB-VN in making decisions about tPA administration on an MSU and does not lead to treatment delays.Clinical Trial Registration—URL: https://www.clinicaltrials.gov. Unique identifier: NCT02190500.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Ritvij Bowry, Stephanie A. Parker, Jose-Miguel Yamal, Hyunsoo Hwang, Savitri Appana, Nicole Rangel-Gutierrez, Tzu-Ching Wu, Suja S. Rajan, James C. Grotta Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research
Effect of Antihypertensive Medication on Cerebral Small Vessel Disease Brief Report
Conclusions—AHM has a protective effect on the progression of white matter hyperintensities, but no effect on brain atrophy. There are no trials on the effect of AHM on lacunes, microbleeds, enlarged perivascular spaces, or acute small subcortical infarcts.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Tessa van Middelaar, Tanja E. Argillander, Floris H.B.M. Schreuder, Jaap Deinum, Edo Richard, Catharina J.M. Klijn Tags: Primary Prevention, Hypertension, Magnetic Resonance Imaging (MRI), Meta Analysis, Cerebrovascular Disease/Stroke Brief Reports Source Type: research
Imaging Endophenotypes of Stroke as a Target for Genetic Studies Topical Review
Source: Stroke - May 25, 2018 Category: Neurology Authors: Xueqiu Jian, Myriam Fornage Tags: Genetic, Association Studies, Genetics, Cerebrovascular Disease/Stroke, Ischemic Stroke Topical Reviews Source Type: research
How to Review a Clinical Research Paper InterSECT
Source: Stroke - April 23, 2018 Category: Neurology Authors: Michael D. Hill Tags: Clinical Studies, Epidemiology, Ischemic Stroke InterSECT Source Type: research
