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Source: Molecular Neurobiology
Education: Study
Therapy: Chemotherapy
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From Chemotherapy-Induced Emesis to Neuroprotection: Therapeutic Opportunities for 5-HT 3 Receptor Antagonists
Abstract
5-HT3 receptor antagonists are extensively used as efficacious agents in counteracting chemotherapy-induced emesis. Recent investigations have shed light on other potential effects (analgesic, anxiolytic, and anti-psychotic). Some studies have reported neuroprotective properties for the 5-HT3 receptor antagonists in vitro and in vivo. When administered to Aβ-challenged rat cortical neurons, 5-HT3 receptor antagonists substantially abated apoptosis, elevation of cytosolic Ca2, glutamate release, reactive oxygen species (ROS) generation, and caspase-3 activity. In addition, in vivo studies show that 5-HT3 ...
Source: Molecular Neurobiology - November 7, 2014 Category: Neurology Source Type: research
