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Antithrombotic Medication and Major Complications After Mechanical Aortic Valve Replacement
Patients with mechanical aortic valve replacement (AVR) require lifelong vitamin K antagonist (VKA) therapy for stroke and systemic embolism prevention. However, VKA treatment predisposes patients to various types of bleeding. In the present study, we sought to assess the success of antithrombotic therapy and the occurrence and timing of strokes and bleeding events after mechanical AVR. A total of 308 patients who underwent isolated mechanical AVR were included in the study, and follow-up data were completed for 306 patients (99.4%).
Source: The American Journal of Cardiology - August 5, 2023 Category: Cardiology Authors: Rikhard Bj örn, Joonas Lehto, Markus Malmberg, Vesa Anttila, K.E. Juhani Airaksinen, Jarmo Gunn, Tuomas Kiviniemi Source Type: research

Transcatheter and Surgical Aortic Valve Implantation in Children, Adolescents, and Young Adults With Congenital Heart Disease
Transcatheter aortic valve implantation (TAVI) is common in adults but rare in children and adolescents. Since 2014, our institution has incorporated a transcatheter approach as an option for aortic valve replacement in this population. The purpose of this study was to compare short-term outcomes of TAVI with surgical aortic valve replacement (SAVR). This single-center, retrospective study included patients aged 10 to 21 years who had a native SAVR or TAVI between January 2010 to April 2020. Comparative analysis of baseline characteristics and a composite outcome (stroke within 6 months, readmission within 30 days, death) ...
Source: The American Journal of Cardiology - June 9, 2022 Category: Cardiology Authors: Dwight M. Robertson, Dana M. Boucek, Mary Hunt Martin, Robert G. Gray, Eric R. Griffiths, Aaron W. Eckhauser, Zhining Ou, Linda M. Lambert, Richard V. Williams, S. Adil Husain Source Type: research

Outcomes of Transcatheter Aortic Valve Replacement with Percutaneous Coronary Intervention versus Surgical Aortic Valve Replacement with Coronary Artery Bypass Grafting
We aimed to compare the outcomes of combined surgical aortic valve replacement (SAVR) with coronary artery bypass grafting (CABG) to concurrent transcatheter aortic valve replacement (TAVR) with percutaneous coronary intervention (PCI) in a large U.S. population sample. The National Inpatient Sample (NIS) was queried for all patients diagnosed with aortic valve stenosis who underwent SAVR with CABG or TAVR with PCI during the years 2016-2017. Study outcomes included all-cause in-hospital mortality, acute stroke, pacemaker insertion, vascular complications, major bleeding, acute kidney injury, sepsis, non-home discharge, le...
Source: The American Journal of Cardiology - September 25, 2020 Category: Cardiology Authors: Ashraf Abugroun, Mohammed Osman, Saria Awadalla, Lloyd Klein Source Type: research

Meta-Analysis Comparing the Frequency of Stroke After Transcatheter Versus Surgical Aortic Valve Replacement
Stroke is one of the most feared complications of aortic valve replacement. Although the outcomes of transcatheter aortic valve implantation (TAVI) improved substantially over time, concerns remained about a potentially higher incidence of stroke with TAVI compared with surgical replacement (SAVR). However, comparative data are sparse. We performed a meta-analysis comparing the incidence of stroke among patients undergoing TAVI versus SAVR. Of the 5067 studies screened, 28 eligible studies (22 propensity-score matched studies and 6 randomized trials) were analyzed.
Source: The American Journal of Cardiology - July 5, 2018 Category: Cardiology Authors: Kuldeep Shah, Zakeih Chaker, Tatiana Busu, Vinay Badhwar, Fahad Alqahtani, Muhammad Alvi, Amelia Adcock, Mohamad Alkhouli Source Type: research

Meta-Analysis Comparing The Frequency of Stroke After Transcatheter vs. Surgical Aortic Valve Replacement
Stroke is one of the most feared complication of aortic valve replacement. Although the outcomes of transcatheter aortic valve implantation (TAVI) improved substantially overtime, concerns remained about a potentially higher incidence of stroke with TAVI compared with surgical replacement (SAVR). However, comparative data are sparse. We performed a meta-analysis comparing the incidence of stroke amongst patients undergoing TAVI versus SAVR. Of the 5067 studies screened, 28 eligible studies (22 propensity-score matched studies and 6 randomized trials) were analyzed.
Source: The American Journal of Cardiology - July 5, 2018 Category: Cardiology Authors: Kuldeep Shah, Zakeih Chaker, Tatiana Busu, Vinay Badhwar, Fahad Alqahtani, Muhammad Alvi, Amelia Adcock, Mohamad Alkhouli Source Type: research

Meta-analysis Comparing Transcatheter and Surgical Treatments of Paravalvular Leaks
Percutaneous paravalvular leak (PVL) closure has emerged as a feasible alternative to redo valve surgery. However, comparative data on percutaneous and surgical treatment of PVL are scarce. We performed a systematic review and a meta-analysis of studies on percutaneous and surgical treatments of PVL. Of the 2,267 studies screened, 22 eligible studies were analyzed. Primary end points were technical success, 30-day mortality, stroke, and length of stay. Secondary end points were 1-year mortality, readmission for heart failure, reoperation, and symptomatic improvement at follow-up.
Source: The American Journal of Cardiology - April 19, 2018 Category: Cardiology Authors: Tatiana Busu, Fahad Alqahtani, Vinay Badhwar, Chris C. Cook, Charanjit S. Rihal, Mohamad Alkhouli Source Type: research

Mata-Analysis Comparing Transcatheter Versus Surgical Treatment of Paravalvular Leaks
Percutaneous paravalvular leak (PVL) closure has emerged as a feasible alternative to redo valve surgery. However, comparative data on percutaneous and surgical treatment of PVL are scarce. We performed a systematic review and a meta-analysis of studies on percutaneous and surgical treatment of PVL. Of the 2267 studies screened, 22 eligible studies were analyzed. Primary endpoints were: technical success, 30-day mortality, stroke and length-of-stay. Secondary endpoints were: 1-year mortality, readmission for heart failure, reoperation, and symptomatic improvement at follow-up.
Source: The American Journal of Cardiology - April 19, 2018 Category: Cardiology Authors: Tatiana Busu, Fahad Alqahtani, Vinay Badhwar, Chris C. Cook, Charanjit S. Rihal, Mohamad Alkhouli Source Type: research

Comparison of Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Chronic Kidney Disease
There are few data comparing outcomes of transcatheter aortic valve implantation (TAVI) vs. surgical aortic valve replacement (SAVR) in patients with chronic kidney disease (CKD). In this retrospective cohort study using the National Inpatient Sample 2011 – 2014, we included a total of 2820 TAVI and 4054 SAVR procedures, representative of 14,039 TAVI and 19,835 SAVR procedures nationally. Co-primary outcomes were in-hospital mortality, acute kidney injury (AKI), dialysis-requiring AKI, and post-operative stroke.
Source: The American Journal of Cardiology - October 31, 2017 Category: Cardiology Authors: Nilay Kumar, Rohan Khera, Neetika Garg, Justin B. Echouffo-Tcheugui, Anand Venkatraman, Ambarish Pandey, Deepak L. Bhatt Source Type: research

Meta-analysis of Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement in patients with Severe Aortic Valve Stenosis Patients
Transcatheter aortic valve replacement (TAVR) is a viable option in the treatment of severe aortic stenosis in patients at high risk for surgery. We sought to further investigate outcomes in low-to-intermediate-risk patients with aortic stenosis undergoing surgical aortic valve replacement (SAVR) versus TAVR. We systematically searched the electronic databases, MEDLINE, PUBMED, EMBASE and Cochrane for prospective cohort studies of the effects of TAVR vs SAVR on clinical outcomes (30-day mortality, all cause mortality, stroke and myocardial infarction [MI], major vascular complications, paravalvular regurgitation, permanent...
Source: The American Journal of Cardiology - November 5, 2015 Category: Cardiology Authors: Ashok Kondur, Alexandros Briasoulis, Mohan Palla, Anirudh Penumetcha, Sagar Mallikethi-Reddy, Apurva Badheka, Theodore Schreiber Source Type: research

Impact of Flow and Left Ventricular Strain on Outcome of Patients With Preserved Left Ventricular Ejection Fraction and Low Gradient Severe Aortic Stenosis Undergoing Aortic Valve Replacement
The prognostic implications of flow, assessed by stroke volume index (SVi), and left ventricular (LV) global longitudinal strain on survival of patients with low-gradient severe aortic stenosis (AS) and preserved LV ejection fraction are debated. The aim of this study was to evaluate the impact of flow and LV global longitudinal strain on survival in these patients treated with aortic valve replacement (AVR). Patients with low-gradient severe AS with preserved LV ejection fraction treated with AVR (n = 134, mean age 76 ± 10 years, 50% men) were included in the present study.
Source: The American Journal of Cardiology - September 25, 2014 Category: Cardiology Authors: Vasileios Kamperidis, Philippe J. van Rosendael, Arnold C.T. Ng, Spyridon Katsanos, Frank van der Kley, Philippe Debonnaire, Emer Joyce, Georgios Sianos, Nina Ajmone Marsan, Jeroen J. Bax, Victoria Delgado Tags: Valvular Heart Disease Source Type: research

Using Simple Imaging Markers to Predict Prognosis in Patients With Aortic Valve Stenosis and Unacceptable High Risk for Operation
Aortic valve stenosis (AS) in patients>75 years of age is a challenge for diagnosis and management of every day clinical routine. Therefore, this clinical follow-up study aims to investigate predictors of death in patients with advanced stages of AS. In a single-center study, all patients (n = 157) with primary conservatively treated severe AS (mean age 78 ± 6 years) were included. All patients had initially refused aortic valve replacement (AVR). During a median follow-up of 2.6 years (quartiles 1.7, 3.8), 62 patients with severe AS switched to AVR and 95 remained conservatively treated (no AVR). Routine clinical data...
Source: The American Journal of Cardiology - September 9, 2013 Category: Cardiology Authors: Sebastian Herrmann, Bart Bijnens, Stefan Störk, Markus Niemann, Kai Hu, Dan Liu, Robin Kettner, Daniel Rau, Jörg Strotmann, Wolfram Voelker, Georg Ertl, Frank Weidemann Tags: Valvular Heart Disease Source Type: research

Frequency of and Determinants of Stroke After Surgical Aortic Valve Replacement in Patients With Previous Cardiac Surgery (from the Multicenter RECORD Initiative)
In conclusion, the risk of postoperative stroke after S-AVR in patients with previous cardiac surgery is high and has an impact on the immediate and late mortality. Excessive bleeding requiring blood transfusion and/or reexploration, prolonged cardiopulmonary bypass time, and use of intra-aortic balloon pump were associated with an extremely high rate of stroke.
Source: The American Journal of Cardiology - September 3, 2013 Category: Cardiology Authors: Fausto Biancari, Francesco Onorati, Giovanni Mariscalco, Marisa De Feo, Antonio Messina, Giuseppe Santarpino, Francesco Santini, Cesare Beghi, Gianantonio Nappi, Giovanni Troise, Theodor Fischlein, Giancarlo Passerone, Jouni Heikkinen, Giuseppe Faggian Tags: Valvular Heart Disease Source Type: research

A Meta-Analysis of Mortality and Major Adverse Cardiovascular and Cerebrovascular Events Following Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement for Severe Aortic Stenosis
The purpose of this meta-analysis was to compare postprocedural mortality and major adverse cardiovascular and cerebrovascular events between transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) for severe aortic stenosis. Seventeen studies (n = 4,659) comparing TAVI (n = 2,267) and SAVR (n = 2,392) were included. End points were baseline logistic European System for Cardiac Operative Risk Evaluation score, all-cause mortality, cardiovascular mortality, myocardial infarction, stroke, transient ischemic attack, and major bleeding events. Mean differences or risk ratios with 95% conf...
Source: The American Journal of Cardiology - June 6, 2013 Category: Cardiology Authors: Hemang B. Panchal, Vatsal Ladia, Saurabh Desai, Tejaskumar Shah, Vijay Ramu Tags: Valvular Heart Disease Source Type: research

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