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Source: The American Journal of Cardiology
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Total 366 results found since Jan 2013.

Effect of Addition of a Statin to Warfarin on Thromboembolic Events in Japanese Patients With Nonvalvular Atrial Fibrillation and Diabetes Mellitus
Statins have been shown to decrease stroke risk in patients with cardiovascular risk factors, but not to prevent recurrence of ischemic stroke in patients with atrial fibrillation (AF). The present subanalysis aimed to clarify the efficacy of combined use of warfarin and statins in nonvalvular AF (NVAF) patients with coronary artery disease (CAD), diabetes mellitus (DM) or hypertension. The effects of adding statins to warfarin were compared with those of warfarin alone in NVAF patients with the data set of J-RHYTHM Registry, a prospective, observational study with a 2-year follow-up.
Source: The American Journal of Cardiology - April 26, 2017 Category: Cardiology Authors: Naoko Kumagai, John A. Nusser, Hiroshi Inoue, Ken Okumura, Takeshi Yamashita, Toru Kubo, Hiroaki Kitaoka, Hideki Origasa, Hirotsugu Atarashi, J-RHYTHM Registry Investigators Source Type: research

Bleeding Risk Scores in Atrial Fibrillation and Venous Thromboembolism
Patients receiving oral anticoagulant (OAC) therapy for stroke prevention in atrial fibrillation (AF) and prevention of venous thromboembolism (VTE) face an increased risk of bleeding with OAC treatment. Clinicians need to weigh-up the benefits of OAC treatment against the risk of bleeding. To help formalise bleeding risk assessment, various bleeding risk scores have been developed to help predict the risk of bleeding in AF and VTE patients receiving anticoagulant therapy. This review summarises the literature involving original studies deriving bleeding risk scores and validation studies of these scores for stroke prevent...
Source: The American Journal of Cardiology - July 14, 2017 Category: Cardiology Authors: Hanis Zulkifly, Gregory Yoke Hong Lip, Deirdre Anne Lane Source Type: research

Serum Ferritin Levels in Blacks Without Known Cardiovascular Disease (From the Jackson Heart Study)
There has been conflicting results regarding the role of ferritin, a nonspecific marker of systemic inflammation, in the development of coronary heart disease (CHD). We aimed to evaluate the association of serum ferritin with incident CHD, incident stroke and subclinical measures of atherosclerosis among Blacks. For our prospective study, we utilized data from the Jackson Heart Study. Eligible participants (N= 4,659) who were free from CHD were enrolled between 2000 and 2004. Their baseline serum ferritin levels were obtained, and they were followed for an average of 8 years to identify incident CHD events and incident stroke.
Source: The American Journal of Cardiology - July 31, 2017 Category: Cardiology Authors: Obiora Egbuche, Heather R Millard, Benjamin Renelus, Maihemuti Axiyan, Solomon K Musani, Ervin R Fox, Jiankang Liu, Herman A Taylor, Aurelian Bidulescu Source Type: research

Meta-Analysis of Effectiveness and Safety of Oral Anticoagulants in Atrial Fibrillation with Focus on Apixaban
We performed a meta-analysis of data on the effectiveness and safety of apixaban compared with other oral anticoagulants (OACs, warfarin or rivaroxaban or dabigatran or edoxaban) for stroke prevention in atrial fibrillation (AF) in different settings of randomized controlled trials (RCTs), real-world studies, and radiofrequency ablation (RFA). 30 studies were searched in PubMed, the Cochrane Library and Clinicaltrials.gov databases reporting comparative effectiveness and safety of apixaban with warfarin (n=23), rivaroxaban (n=12) or dabigatran (n=13) or edoxaban (2) for stroke prevention in AF.
Source: The American Journal of Cardiology - August 1, 2017 Category: Cardiology Authors: Ying Bai, Xu-Bo Shi, Chang-Sheng Ma, Gregory Y H Lip Source Type: research

Frequency of Inverted Electrocardiographic T-Waves (Cerebral T-Waves) in Patients with Acute Strokes and Their Relation to Left Ventricular Wall Motion Abnormalities
Transient, symmetric and deep inverted ECG T-waves in the setting of stroke, commonly referred to as cerebral T-waves, are rare and the underlying mechanism is unclear. Our study aimed to test the hypothesis that cerebral T-waves are associated with transient cardiac dysfunction. This retrospective study included 800 patients admitted with the primary diagnosis of hemorrhagic or ischemic stroke. Electrocardiograms were examined for cerebral T waves, defined as T-wave inversion of ≥5 mm depth in ≥4 contiguous precordial leads.
Source: The American Journal of Cardiology - November 14, 2017 Category: Cardiology Authors: Jeremy Stone, Victor Mor-Avi, Agnieszka Ardelt, Roberto M. Lang Source Type: research

Frequency of Inverted Electrocardiographic T Waves (Cerebral T Waves) in Patients With Acute Strokes and Their Relation to Left Ventricular Wall Motion Abnormalities
Transient, symmetric, and deep inverted electrocardiogram (ECG) T waves in the setting of stroke, commonly referred to as cerebral T waves, are rare, and the underlying mechanism is unclear. Our study aimed to test the hypothesis that cerebral T waves are associated with transient cardiac dysfunction. This retrospective study included 800 patients admitted with the primary diagnosis of hemorrhagic or ischemic stroke. ECGs were examined for cerebral T waves, defined as T-wave inversion of ≥5 mm depth in ≥4 contiguous precordial leads.
Source: The American Journal of Cardiology - November 14, 2017 Category: Cardiology Authors: Jeremy Stone, Victor Mor-Avi, Agnieszka Ardelt, Roberto M. Lang Source Type: research

Anticoagulant Agents for Atrial Fibrillation in Cancer Patients
In a recent article in the journal, Patell et al1 found CHADS2 and CHA2DS2VASC to predict risk of ischemic stroke in cancer patients with baseline atrial fibrillation (AF). Although only 36% of patients received anticoagulant therapy, the risk of stroke generally appeared to be lower than in cancer-free individuals2,3. Given the size and statistical rigor of the analysis, and the perplexing paucity of published data regarding the management of coexisting AF and cancer, the study by Patell et al1 is of outstanding worth.
Source: The American Journal of Cardiology - February 3, 2018 Category: Cardiology Authors: Marc Sorigue, Edurne Sarrate, Mireia Franch-Sarto, Mireia Santos-Gomez, Elisa Orna Source Type: research

Feasibility of Left Atrial Appendage Occlusion for Left Atrial Appendage Thrombus in Patients with Persistent Atrial Fibrillation
This study sought to investigate the safety of percutaneous left atrial appendage (LAA) occlusion for stroke prevention in patients of nonvalvular atrial fibrillation with LAA thrombus. From October 2010 to October 2016, LAA occlusions were performed in facilities within a Korean multicenter registry in patients without (n = 132) or with (n = 10) LAA thrombus (detected during preprocedural assessments). The incidences of periprocedural complications, including stroke, pericardial tamponade, major bleeding, and device embolization, were assessed and compared between the groups.
Source: The American Journal of Cardiology - March 14, 2018 Category: Cardiology Authors: Oh-Hyun Lee, Jung-Sun Kim, Hui-Nam Pak, Geu-Ru Hong, Chi Young Shim, Jae-Sun Uhm, In-Jeong Cho, Boyoung Joung, Cheol-Woong Yu, Hyun-Jong Lee, Woong-Chol Kang, Eun-Seok Shin, Rak-kyeong Choi, Do-Sun Lim, Yangsoo Jang Source Type: research

Feasibility of Left Atrial Appendage Occlusion for Left Atrial Appendage Thrombus in Patients With Persistent Atrial Fibrillation
This study sought to investigate the safety of percutaneous left atrial appendage (LAA) occlusion for stroke prevention in patients with nonvalvular atrial fibrillation who have LAA thrombus. From October 2010 to October 2016, LAA occlusions were performed in facilities within a Korean multicenter registry in patients without (n  = 132) or with (n = 10) LAA thrombus (detected during preprocedural assessments). The incidences of periprocedural complications, including stroke, pericardial tamponade, major bleeding, and device embolization, were assessed and compared between the groups.
Source: The American Journal of Cardiology - March 14, 2018 Category: Cardiology Authors: Oh-Hyun Lee, Jung-Sun Kim, Hui-Nam Pak, Geu-Ru Hong, Chi Young Shim, Jae-Sun Uhm, In-Jeong Cho, Boyoung Joung, Cheol-Woong Yu, Hyun-Jong Lee, Woong-Chol Kang, Eun-Seok Shin, Rak-kyeong Choi, Do-Sun Lim, Yangsoo Jang Source Type: research

PFO-mediated Stroke: Exposing the Misnomer of ‘Cryptogenic’ Stroke
We read with interest the recent article by Wintzer-Wehekind et al1. In an observational study of 453 consecutive patients who underwent PFO closure due to an ischemic event of no other apparent cause, the authors evaluated the safety of discontinuing antithrombotic therapy following PFO closure. At a median follow-up of 8 years, antithrombotic therapy was associated with a 6% incidence of bleeding, and the subset of patients who discontinued their blood thinners did not have more recurrent ischemic events on long-term follow-up.
Source: The American Journal of Cardiology - March 15, 2019 Category: Cardiology Authors: Muhammad O. Zaman, Sanaullah Mojaddedi, Fabian Nietlispach, Bernhard Meier, Mohammad K. Mojadidi Source Type: research

Discriminative Ability of CHA2DS2-VASc and HAS-BLED Score in Whites and Non-Whites
The CHA2DS2-VASc and HAS-BLED scoring systems are used in patients with atrial fibrillation (AF) to estimate risk of stroke and bleeding, respectively. Both were developed in minimally diverse European populations and these scores have not yet been extensively studied in US whites and non-whites. In a retrospective cohort study, we included patients with AF who received inpatient or outpatient care in a large integrated academic health system from 2011 to 2017. Cox proportional hazards were used to analyze associations between stroke and CHA2DS2-VASc score in AF patients not prescribed anticoagulation and between incident ...
Source: The American Journal of Cardiology - March 18, 2019 Category: Cardiology Authors: Sarah M Schwartz, Yacob G Tedla, Philip Greenland, Ajay Yadlapati, Rod Passman Source Type: research

Discriminative Ability of CHA2DS2-VASc and HAS-BLED Score in Whites and Nonwhites
The CHA2DS2-VASc and HAS-BLED scoring systems are used in patients with atrial fibrillation (AF) to estimate risk of stroke and bleeding, respectively. Both were developed in minimally diverse European populations and these scores have not yet been extensively studied in US whites and nonwhites. In a retrospective cohort study, we included patients with AF who received inpatient or outpatient care in a large integrated academic health system from 2011 to 2017. Cox proportional hazards were used to analyze associations between stroke and CHA2DS2-VASc score in AF patients not prescribed anticoagulation and between incident b...
Source: The American Journal of Cardiology - March 18, 2019 Category: Cardiology Authors: Sarah M. Schwartz, Yacob G. Tedla, Philip Greenland, Ajay Yadlapati, Rod S. Passman Source Type: research

Meta-Analysis Evaluating the Safety and Efficacy of Transcarotid Transcatheter Aortic Valve Implantation
We performed a systemic review and meta-analysis of studies evaluating transcarotid vascular access for transcatheter aortic valve implantation (TAVI). Published studies evaluating transcarotid vascular access for TAVI were included in this analysis. Outcomes of interest included thirty-day mortality, stroke/TIA, new pacemaker implantation, acute kidney injury (AKI), major vascular complication, major bleeding, and myocardial infarction. Pooled estimate for 30-day mortality was 5.3% (95% CI: 4.0%-6.8%; I2=4%), stroke/TIA was 3.4% (95% CI: 2.4%-4.6%; I2=0%), new pacemaker implantation was 15.3% (95% CI: 10.8%-19.7%; I2=72%)...
Source: The American Journal of Cardiology - September 24, 2019 Category: Cardiology Authors: Muhammad Shariq Usman, Wasiq Faraz Rawasia, Tariq Jamal Siddiqi, Firzah Abdul Mujeeb, Shahrukh Nadeem, Mohamad Alkhouli Source Type: research

Frequency, Trends and Outcomes of Cerebrovascular Events Associated with Atrial Fibrillation Hospitalizations
Atrial Fibrillation (AF) is the leading heart rhythm disorder with lifetime risk as high as 1 in 3 people across the world, contributing significantly to the risk of stroke, heart failure and mortality.1, 2 The incidence and prevalence of AF continue to increase for many reasons including, but not limited to the aging population in the Unites States and the newer technological modalities such as smartwatch detecting AF early among asymptomatic patients.3, 4 It is well established that AF is an independent risk factor for stroke as demonstrated by the Framingham study, and in recent times has been implicated in cryptogenic strokes.
Source: The American Journal of Cardiology - October 12, 2020 Category: Cardiology Authors: Rajkumar Doshi, Devina Adalja, Ashish Kumar, Mihir Dave, Mariam Shariff, Jay Shah, Nageshwara Gullapalli, Rupak Desai, Chintan Rupareliya, Yasar Sattar, Saraschandra Vallabhajosyula Source Type: research

Frequency, Trends, and Outcomes of Cerebrovascular Events Associated With Atrial Fibrillation Hospitalizations
Atrial Fibrillation (AF) is the leading heart rhythm disorder with lifetime risk as high as 1 in 3 people across the world, contributing significantly to the risk of stroke, heart failure and mortality.1,2 The incidence and prevalence of AF continue to increase for many reasons including, but not limited to the aging population in the Unites States and the newer technological modalities such as smartwatch detecting AF early among asymptomatic patients.3,4 It is well established that AF is an independent risk factor for stroke as demonstrated by the Framingham study, and in recent times has been implicated in cryptogenic strokes.
Source: The American Journal of Cardiology - October 12, 2020 Category: Cardiology Authors: Rajkumar Doshi, Devina Adalja, Ashish Kumar, Mihir Dave, Mariam Shariff, Jay Shah, Nageshwara Gullapalli, Rupak Desai, Chintan Rupareliya, Yasar Sattar, Saraschandra Vallabhajosyula Source Type: research