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Comparison of Risk of Atrial Fibrillation among Employed Versus Unemployed (From the REasons for Geographic and Racial Differences in Stroke Study)
Involuntary unemployment due to job loss has been associated with increased risk of cardiovascular events. Whether it also is associated with increased risk of atrial fibrillation (AF) is currently unknown. Therefore, we examined this association in 8,812 participants residing mainly in the Southeastern United States (mean age 58.1 ± 7.8 years; 63.2%; women; 43.2% black) with data on employment status who were enrolled in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study between 2003 and 2007 after excluding those with voluntary unemployment (e.g.
Source: The American Journal of Cardiology - July 21, 2017 Category: Cardiology Authors: Elsayed Z. Soliman, Zhu-Ming Zhang, Suzanne Judd, Virginia J. Howard, George Howard Source Type: research

Short- and Long-Term Mortality and Stroke Risk after Transcatheter Aortic Valve Implantation
No published studies have compared the outcome after transcatheter aortic valve implantation (TAVI) with the outcome in the general population. Thus, it is unknown whether TAVI restores normal life expectancy and stroke risk. Furthermore, despite the increasing use of TAVI, only little is known about the temporal trends for TAVI regarding patient characteristics and outcomes. We identified all Danish patients treated with TAVI from 2006-2014 (n=1,631) and 9,737 general population controls matched by sex, age and comorbidity.
Source: The American Journal of Cardiology - October 10, 2017 Category: Cardiology Authors: Lars Jakobsen, Christian J. Terkelsen, Lars S øndergaard, Ole D. Backer, Jens Aarøe, Henrik Nissen, Søren P. Johnsen, Evald H. Christiansen Source Type: research

Usefulness of the American Heart Association's Life Simple 7 to Predict the Risk of Atrial Fibrillation (From the REasons for Geographic and Racial Differences in Stroke REGARDS Study)
The American Heart Association has identified metrics of ideal cardiovascular (CV) health known as Life's Simple 7 (LS7). We determined the prospective relationship between the LS7 and incident AF in a biracial cohort. The Reasons for Geographic and Racial Differences in Stroke (REGARDS) study enrolled non-Hispanic black and white adults 45 years or older. This analysis included 9,576 REGARDS participants (mean age 63 ± 8.4 years; 57% women; 30% black) who were free of AF at baseline and completed a follow-up exam 9.4 years later.
Source: The American Journal of Cardiology - October 19, 2017 Category: Cardiology Authors: Parveen K. Garg, Wesley T. O'Neal, Adedotun Ogunsua, Evan L. Thacker, George Howard, Elsayed Z. Soliman, Mary Cushman Source Type: research

Prediction of Incident Atrial Fibrillation According to Gender in Patients with Ischemic Stroke From a Nationwide Cohort
The CHA2DS2-VASc score may identify patients at higher risk of atrial fibrillation (AF) following ischemic stroke (IS) among patients without known AF. We compared gender-related differences in items from CHA2DS2-VASc score and their relationship with AF occurrence after IS. This French cohort study was based on the database covering hospital care from 2009 to 2012 for the entire population. Of 336,291 patients with IS, 240,459 (71.5%) had no AF at baseline. Women were older, more frequently had hypertension, heart failure, and had a higher CHA2DS2-VASc score than men (4.63 vs 4.39, p
Source: The American Journal of Cardiology - November 30, 2017 Category: Cardiology Authors: Arnaud Bisson, Alexandre Bodin, Nicolas Clementy, Dominique Babuty, Gregory Y.H. Lip, Laurent Fauchier Source Type: research

Effectiveness and Safety of Direct Oral Anticoagulants and Warfarin, Stratified by Stroke Risk in Patients with Atrial Fibrillation
The objective of the study was to examine how the comparative effectiveness and safety of direct oral anticoagulants (DOACs) and warfarin differ across subgroups of atrial fibrillation (AF) patients defined by stroke risk (CHA2DS2-VASc score ≤3, 4-5, ≥6). Using claims data from a 5% random sample of Medicare beneficiaries, we identified patients newly diagnosed with AF in 2013-2014 who initiated warfarin (n=12,354), apixaban (n=2,358), dabigatran (n=1,415) or rivaroxaban (n=5,139), and categorized them according to their CHA2DS2-VAS c score (≤3, 4-5, ≥6).
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Inmaculada Hernandez, Yuting Zhang, Samir Saba Source Type: research

Usefulness of Proneurotensin to Predict Cardiovascular and All-Cause Mortality in a United States Population (From the REasons for Geographic and Racial Differences in Stroke Study)
Cardiovascular disease is a leading cause of death. Proneurotensin is a biomarker associated with the development of cardiovascular disease, cardiovascular mortality, and all-cause mortality. We assessed the association of fasting proneurotensin with mortal events by sex and race (black-white) in a United States (US) population. Using a case-cohort sub-population of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, fasting proneurotensin was measured on a 1046-person subcohort and 651 participants with incident coronary heart disease (CHD).
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Nicholas Wettersten, Mary Cushman, Virginia J. Howard, Oliver Hartmann, Gerasimos Filippatos, Neil Beri, Paul Clopton, George Howard, Monika M. Safford, Suzanne E. Judd, Andreas Bergmann, Joachim Struck, Alan Maisel Source Type: research

Effectiveness and Safety of Direct Oral Anticoagulants and Warfarin, Stratified by Stroke Risk in Patients With Atrial Fibrillation
The objective of the study was to examine how the comparative effectiveness and safety of direct oral anticoagulants (DOACs) and warfarin differ across subgroups of patients with atrial fibrillation defined by stroke risk (CHA2DS2-VASc score ≤3, 4 to 5, ≥6). Using Medicare claims data, we identified patients newly diagnosed with atrial fibrillation in 2013 to 2014 who initiated warfarin (n=12,354), apixaban (n=2,358), dabigatran (n=1,415), or rivaroxaban (n=5,139), and categorized them according to their CHA2DS2-VASc score (≤3, 4 to 5, ≥6).
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Inmaculada Hernandez, Yuting Zhang, Samir Saba Source Type: research

Usefulness of Proneurotensin to Predict Cardiovascular and All-Cause Mortality in a United States Population (From the REasons for Geographic and Racial Differences in Stroke Study)
Cardiovascular disease is a leading cause of death. Proneurotensin is a biomarker associated with the development of cardiovascular disease, cardiovascular mortality, and all-cause mortality. We assessed the association of fasting proneurotensin with mortal events by sex and race (black-white) in a United States (US) population. Using a case-cohort sub-population of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, fasting proneurotensin was measured on a 1046-person subcohort and 651 participants with incident coronary heart disease (CHD).
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Nicholas Wettersten, Mary Cushman, Virginia J. Howard, Oliver Hartmann, Gerasimos Filippatos, Neil Beri, Paul Clopton, George Howard, Monika M. Safford, Suzanne E. Judd, Andreas Bergmann, Joachim Struck, Alan Maisel Source Type: research

Usefulness of the CHA2DS2-VASc and HAS-BLED Scores in Predicting the Risk of Stroke Versus Intracranial Bleeding in Patients With Atrial Fibrillation (from the FibStroke Study)
CHA2DS2-VASc and HAS-BLED scores stratify the risk of thromboembolic and bleeding events respectively in patients with atrial fibrillation. There is only little information on how they differentiate which of the 2 clinically most important complications (ischemic stroke [IS] or an intracranial bleeding [IB]) the patient is more prone to suffer. We evaluated both scores in patients with either of these major complications. The FibStroke Study collected data on all patients with atrial fibrillation with either an IS or an IB event between 2003 and 2012 in 4 Finnish hospital districts.
Source: The American Journal of Cardiology - February 12, 2018 Category: Cardiology Authors: Samuli Jaakkola, Tuomas O. Kiviniemi, Ilpo Nuotio, Juha Hartikainen, Pirjo Mustonen, Antti Palom äki, Jussi Jaakkola, Antti Ylitalo, Päivi Hartikainen, K.E. Juhani Airaksinen Source Type: research

Willingness to be Re-initiated on a Statin (From the REasons for Geographic And Racial Differences in Stroke REGARDS Study)
Guidelines recommend attempting to re-initiate statins in patients who discontinue treatment. Prior experiences while taking a statin, including side effects, may reduce a person's willingness to re-initiate treatment. We determined the percentage of adults who are willing to re-initiate statin therapy after treatment discontinuation. Factors associated with willingness to re-initiate a statin were also examined. A statin questionnaire was administered and study examination conducted among black and white US adults enrolled in the nationwide REasons for Geographic And Racial Differences in Stroke (REGARDS) study between 2013 and 2017.
Source: The American Journal of Cardiology - June 2, 2018 Category: Cardiology Authors: Matthew T. Mefford, Gabriel S. Tajeu, Rikki M. Tanner, Lisandro D. Colantonio, Keri L. Monda, Ricardo Dent, Michael E. Farkouh, Robert S. Rosenson, Monika M. Safford, Paul Muntner Source Type: research

Willingness to be Reinitiated on a Statin (from the REasons for Geographic and Racial Differences in Stroke Study)
Guidelines recommend attempting to reinitiate statins in patients who discontinue treatment. Previous experiences while taking a statin, including side effects, may reduce a patient ’s willingness to reinitiate treatment. We determined the percentage of adults who are willing to reinitiate statin therapy after treatment discontinuation. Factors associated with willingness to reinitiate a statin were also examined. A statin questionnaire was administered and study examination conducted in black and white US adults enrolled in the nationwide REasons for Geographic And Racial Differences in Stroke study from 2013 to 2017.
Source: The American Journal of Cardiology - June 2, 2018 Category: Cardiology Authors: Matthew T. Mefford, Gabriel S. Tajeu, Rikki M. Tanner, Lisandro D. Colantonio, Keri L. Monda, Ricardo Dent, Michael E. Farkouh, Robert S. Rosenson, Monika M. Safford, Paul Muntner Source Type: research

Lifetime Pattern of Atrial Fibrillation and the Risks of Stroke and Death in a Population-based Cohort of Men (From The Manitoba Follow-Up Study)
Atrial Fibrillation (AF) is associated with stroke and mortality. The arrhythmia can be sustained or intermittent. Prior studies that have used fixed covariates and short time horizons to examine the relationship between the pattern of AF and the occurrence of events have produced conflicting results. The Manitoba Follow-Up Study includes 3983 originally healthy men who have been followed with routine examinations since 1948. AF status during each visit was classified into the following patterns: free of AF, newly-diagnosed; intermittent AF – in sinus; intermittent AF – in AF; sustained AF.
Source: The American Journal of Cardiology - August 20, 2018 Category: Cardiology Authors: William F. McIntyre, Philip D. St John, Mahmoud Torabi, Robert B. Tate Source Type: research

Medication-taking Behaviors and Perceptions Among Adults with Heart Failure (From the REasons for Geographic And Racial Differences in Stroke REGARDS Study)
We examined medication-taking behaviors and perceptions among individuals with HF with a particular focus on BBs. A mailed survey on medication use was administered to US adults with HF enrolled in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
Source: The American Journal of Cardiology - February 23, 2019 Category: Cardiology Authors: Matthew T. Mefford, Alysse Sephel, Melissa K. Van Dyke, Ligong Chen, Raegan W. Durant, Todd M. Brown, Matthew Fifolt, Juan Maya, Parag Goyal, Monika M. Safford, Emily B. Levitan Source Type: research

Stroke and Systemic Embolism and other Adverse Outcomes of Heart Failure with Preserved and Reduced Ejection Fraction in Patients with Atrial Fibrillation (From the COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation CODE-AF)
It is unknown whether heart failure (HF) with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) carry a similar risk of stroke or systemic embolism (SE) and other outcomes in patients with non-valvular atrial fibrillation (AF). A prospective, multicenter outpatient registry with echocardiographic data which enrolled 10,589 patients from June 2016 to May 2019 was analyzed. In this registry, 935 (8.8%) patients had HF, and the proportions of patients with HFpEF and HFrEF were 43.2% and 56.8%, respectively.
Source: The American Journal of Cardiology - October 9, 2019 Category: Cardiology Authors: Seyong Chung, Tae-Hoon Kim, Jae-Sun Uhm, Myung-Jin Cha, Jung-Myung Lee, Junbeom Park, Jin-Kyu Park, Ki-Woon Kang, Jun Kim, Hyung Wook Park, Eue-Keun Choi, Jin-Bae Kim, Chang-Soo Kim, Young Soo Lee, Jaemin Shim, Boyoung Joung Source Type: research

Validation of Acute Ischemic Stroke Codes Using the International Classification of Diseases Tenth Revision
Administrative databases have increasingly become a platform for clinical investigations aiming to address trends in the prevalence, patterns of care, and outcomes of major cardiovascular diseases including strokes1-4. Identification of acute ischemic stroke (AIS) events in these databases is dependent on billing codes. Hence, accurate querying of administrative databases for research purposes require proper validation of those billing codes. Several studies have previously validated the use of certain International Classification of Diseases-Ninth Revision-Clinical Modification (ICD-9-CM) codes to discern hospitalizations for AIS.
Source: The American Journal of Cardiology - January 7, 2020 Category: Cardiology Authors: Mohamed Alhajji, Akram Kawsara, Mohamad Alkhouli Source Type: research

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