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Source: The American Journal of Cardiology
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Total 366 results found since Jan 2013.
Patent Foramen Ovale Closure —When Number Needed to Treat and Number Needed to Harm Do Not Tell the Whole Story
We read with interest the thorough meta-analysis of Ando et al1 comparing patent foramen ovale (PFO) closure against medical therapy. The authors showed that PFO closure reduced the risk of recurrent stroke by 58%, with a number needed to treat of 38. PFO closure plus medical therapy, however, conferred a significant increase in risk of newly detected atri al fibrillation (AF), with a number needed to harm (NNH) of 29. With 4.3%, the prevalence of newly detected AF after PFO closure was similar to the one of 3.7% (95% confidence interval 2.9 to 4.6) in a recent large retrospective cohort study of 1,887 patients.
Source: The American Journal of Cardiology - February 13, 2018 Category: Cardiology Authors: Franz H. Messerli, Bernhard Meier Source Type: research
Financial Implications and Impact of Pre-Existing Atrial Fibrillation on in-Hospital Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation (From the National Inpatient Database)
The objective of this study was to evaluate the financial implications and the impact of pre-existing atrial fibrillation (AF) on in-hospital outcomes in patients undergoing transcatheter aortic valve implantation (TAVI) using the Nationwide Inpatient Sample (NIS) database. We identified patients who underwent TAVI from 2011 to 2014. The primary endpoint was the effect of pre-existing AF on in-hospital mortality. Secondary endpoints included peri-procedural cardiac complications, stroke and hemorrhage requiring transfusion.
Source: The American Journal of Cardiology - March 14, 2018 Category: Cardiology Authors: Hossam Abubakar, Ahmed Salah Yassin, Emmanuel Akintoye, Khalid Bakhit, Mohit Pahuja, Mohamed Shokr, Randy Lieberman, Luis Afonso Source Type: research
Impact of Balloon Predilatation on Hemodynamics and Outcomes After Transcatheter Aortic Valve Implantation With the Self-Expanding CoreValve Prosthesis
The impact of predilatation (Pre-Dil) on prosthesis hemodynamics and clinical outcomes of subjects who underwent transcatheter aortic valve implantation (TAVI) with a self-expanding prosthesis remains unclear. Two thousand seven hundred twenty-one subjects from the extreme- and high-risk CoreValve Continued Access Study (CAS) were included in the analysis. Subjects who underwent Pre-Dil before TAVI were compared with subjects who underwent TAVI without Pre-Dil. Clinical outcomes included death, stroke, myocardial infarction, acute kidney injury, and new permanent pacemaker implantation.
Source: The American Journal of Cardiology - March 1, 2018 Category: Cardiology Authors: Toby Rogers, Ron Waksman, J. Kevin Harrison, G. Michael Deeb, Angie Q. Zhang, James B. Hermiller, Jeffrey J. Popma, Michael J. Reardon Source Type: research
Mata-Analysis Comparing Transcatheter Versus Surgical Treatment of Paravalvular Leaks
Percutaneous paravalvular leak (PVL) closure has emerged as a feasible alternative to redo valve surgery. However, comparative data on percutaneous and surgical treatment of PVL are scarce. We performed a systematic review and a meta-analysis of studies on percutaneous and surgical treatment of PVL. Of the 2267 studies screened, 22 eligible studies were analyzed. Primary endpoints were: technical success, 30-day mortality, stroke and length-of-stay. Secondary endpoints were: 1-year mortality, readmission for heart failure, reoperation, and symptomatic improvement at follow-up.
Source: The American Journal of Cardiology - April 19, 2018 Category: Cardiology Authors: Tatiana Busu, Fahad Alqahtani, Vinay Badhwar, Chris C. Cook, Charanjit S. Rihal, Mohamad Alkhouli Source Type: research
Financial Implications and Impact of Pre-existing Atrial Fibrillation on In-Hospital Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the National Inpatient Database)
The objective of this study was to evaluate the financial implications and the impact of pre-existing atrial fibrillation (AF) on in-hospital outcomes in patients who underwent transcatheter aortic valve implantation (TAVI) using the Nationwide Inpatient Sample (NIS) database. We identified patients who underwent TAVI from 2011 to 2014. The primary end point was the effect of pre-existing AF on in-hospital mortality. Secondary end points included periprocedural cardiac complications, stroke, and hemorrhage requiring transfusion.
Source: The American Journal of Cardiology - March 14, 2018 Category: Cardiology Authors: Hossam Abubakar, Ahmed S. Yassin, Emmanuel Akintoye, Khalid Bakhit, Mohit Pahuja, Mohamed Shokr, Randy Lieberman, Luis Afonso Source Type: research
Impact of Balloon Predilatation on Hemodynamics and Outcomes After Transcatheter Aortic Valve Implantation With the Self-Expanding CoreValve Prosthesis
The impact of predilatation (Pre-Dil) on prosthesis hemodynamics and clinical outcomes of subjects who underwent transcatheter aortic valve implantation (TAVI) with a self-expanding prosthesis remains unclear. Two thousand seven hundred twenty-one subjects from the extreme- and high-risk CoreValve Continued Access Study (CAS) were included in the analysis. Subjects who underwent Pre-Dil before TAVI were compared with subjects who underwent TAVI without Pre-Dil. Clinical outcomes included death, stroke, myocardial infarction, acute kidney injury, and new permanent pacemaker implantation.
Source: The American Journal of Cardiology - March 1, 2018 Category: Cardiology Authors: Toby Rogers, Ron Waksman, J. Kevin Harrison, G. Michael Deeb, Angie Q. Zhang, James B. Hermiller, Jeffrey J. Popma, Michael J. Reardon Source Type: research
Patent Foramen Ovale Closure —When Number Needed to Treat and Number Needed to Harm Do Not Tell the Whole Story
We read with interest the thorough meta-analysis of Ando et al1 comparing patent foramen ovale (PFO) closure against medical therapy. The authors showed that PFO closure reduced the risk of recurrent stroke by 58%, with a number needed to treat of 38. PFO closure plus medical therapy, however, conferred a significant increase in risk of newly detected atri al fibrillation (AF), with a number needed to harm (NNH) of 29. With 4.3%, the prevalence of newly detected AF after PFO closure was similar to the one of 3.7% (95% confidence interval 2.9 to 4.6) in a recent large retrospective cohort study of 1,887 patients.
Source: The American Journal of Cardiology - February 13, 2018 Category: Cardiology Authors: Franz H. Messerli, Bernhard Meier Source Type: research
Frequency of Electrocardiographic Abnormalities in Patients With Psoriasis
Psoriasis is a chronic inflammatory disease associated with cardiovascular disease, for example, myocardial infarction, stroke, cardiovascular death, and arrhythmias. The resting electrocardiogram may carry prognostic information, but limited evidence is available of electrocardiographic findings in subjects with psoriasis. The electrocardiographic results were compared between 1,131 subjects with self-reported psoriasis and 18,397 controls participating in the Danish General Suburban Population Study (GESUS).
Source: The American Journal of Cardiology - February 4, 2018 Category: Cardiology Authors: Peter Riis Hansen, Christian Rimer Juhl, Jonas Lynggaard Isaksen, Gregor Borut Jemec, Christina Ellervik, J ørgen Kim Kanters Tags: Miscellaneous Source Type: research
Meta-analysis of the Impact of Avoiding Balloon Predilation in Transcatheter Aortic Valve Implantation
Balloon predilation (BPD) has been an integral part of transcatheter aortic valve implantation (TAVI) since inception. We sought to investigate the effect of avoiding BPD on outcomes of TAVI across different valve types. Articles were included if outcomes of TAVI without BPD were reported. Pooled meta-analysis used a random effects model and reported Odds Ratios (OR). Twenty-one studies with 10,752 patients were pooled for analysis. Age and gender were well matched between NoBPD and BPD groups. There was no difference in mortality, stroke, bleeding, and acute kidney injury.
Source: The American Journal of Cardiology - April 30, 2018 Category: Cardiology Authors: Kinjal Banerjee, Krishna Kandregula, Kesavan Sankaramangalam, Anil Anumandla, Arnav Kumar, Parth Parikh, Jimmy Kerrigan, Shameer Khubber, Amar Krishnaswamy, Stephanie Mick, Jonathon White, Lars Svensson, Samir Kapadia Source Type: research
Relation of Electrocardiographic Left Atrial Abnormalities to Risk of Stroke in Patients with Atrial Fibrillation
The P wave terminal force in lead V1 (PTFV1) on the 12-lead ECG quantifies left atrial (LA) structural and electrophysiological abnormalities. We aimed to evaluate the association between PTFV1 and cerebrovascular accident (CVA) as well as LA structure and function in patients with atrial fibrillation (AF). We conducted a cross-sectional study of 229 patients with AF (60 ±10 years, 72% male) with (n=21) and without (n=208) a history of CVA, who underwent pre-ablation ECG and cardiac magnetic resonance (CMR) in sinus rhythm.
Source: The American Journal of Cardiology - May 2, 2018 Category: Cardiology Authors: Yuko Y. Inoue, Esra G. Ipek, Irfan M. Khurram, Luisa Ciuffo, Jonathan Chrispin, Stefan L. Zimmerman, Joseph E. Marine, John Rickard, David D. Spragg, Saman Nazarian, Kengo Kusano, Joao A. Lima, Ronald D. Berger, Hugh Calkins, Hiroshi Ashikaga Source Type: research
Meta-analysis Comparing Transcatheter and Surgical Treatments of Paravalvular Leaks
Percutaneous paravalvular leak (PVL) closure has emerged as a feasible alternative to redo valve surgery. However, comparative data on percutaneous and surgical treatment of PVL are scarce. We performed a systematic review and a meta-analysis of studies on percutaneous and surgical treatments of PVL. Of the 2,267 studies screened, 22 eligible studies were analyzed. Primary end points were technical success, 30-day mortality, stroke, and length of stay. Secondary end points were 1-year mortality, readmission for heart failure, reoperation, and symptomatic improvement at follow-up.
Source: The American Journal of Cardiology - April 19, 2018 Category: Cardiology Authors: Tatiana Busu, Fahad Alqahtani, Vinay Badhwar, Chris C. Cook, Charanjit S. Rihal, Mohamad Alkhouli Source Type: research
Extended Cardiac Monitoring in Patients with Severe Sleep Apnea and no History of Atrial Fibrillation (The Reveal XT-SA Study)
Atrial fibrillation (AF) is a risk factor for ischemic stroke and reported to be associated with severe obstructive sleep apnea (OSA). The aim of this study was to determine the occurrence of newly detected AF in patients with severe OSA and no prior history of AF. Prospective observational study included patients with severe OSA (Apnea-Hypopnea Index (AHI) ≥ 30) and no history of AF. Primary outcome was detection of AF lasting ≥10 s. Patients were subjected to 2 24-hour Holter monitors, and if no AF was detected, implanted with a Medtronic Reveal XT implantable loop recorder (ILR).
Source: The American Journal of Cardiology - September 7, 2018 Category: Cardiology Authors: Cynthia Yeung, Doran Drew, Sharlene Hammond, Wilma M. Hopman, Damian Redfearn, Christopher Simpson, Hoshiar Abdollah, Adrian Baranchuk Source Type: research
Meta-Analysis comparing Outcomes of Drug Eluting Stents versus Single and Multi-Arterial Coronary Artery Bypass Grafting
Relative benefits of coronary artery bypass (CABG) using single and multiple arterial grafting (SAG, MAG) and drug eluting stent (DES) in multivessel coronary disease remain uncertain. We compared SAG, MAG and DES in a pairwise and network meta-analysis. Randomized trials and adjusted observational studies comparing CABG versus DES were included (primary endpoint: long-term mortality; secondary endpoints: operative mortality, perioperative stroke and follow-up repeated revascularization [RR]). Studies with ≥1.7arterial grafts/patient were classified as MAG.
Source: The American Journal of Cardiology - September 13, 2018 Category: Cardiology Authors: Mario Gaudino, Mohamed Rahouma, Ahmed Abouarab, Derrick Y Tam, Antonino Di Franco, Jeremy Leonard, Umberto Benedetto, Mario Iannaccone, Fabrizio D'Ascenzo, Giuseppe Biondi-Zoccai, Michael Vallely, Leonard N Girardi, Stephen E Fremes, David P Taggart Source Type: research
Prevalence and Resolution of Left Atrial Thrombus in Patients With Nonvalvular Atrial Fibrillation and Flutter With Oral Anticoagulation
This study sought to establish 1) the prevalence of LAA thrombus 2) the prevalence of LAA thrombus despite antithrombotic therapy, 3) the rate of persistence of LAA thrombus despite appropriate anticoagulant prescriptions, and 4) determinants of LAA thrombus persistence.
Source: The American Journal of Cardiology - September 26, 2018 Category: Cardiology Authors: Adam D Niku, Takahiro Shiota, Robert J Siegel, Florian Rader Source Type: research
