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Source: The American Journal of Cardiology
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Total 366 results found since Jan 2013.
Anticoagulation Control in Warfarin Treated Patients Undergoing Cardioversion for Atrial Fibrillation (From the ENSURE-AF Trial)
In the ENSURE-AF study (NCT 02072434), edoxaban was compared to enoxaparin –warfarin in 2199 patients undergoing electrical cardioversion of non-valvular atrial fibrillation (AF). In this multicenter PROBE trial, we analyzed patients randomized to enoxaparin–warfarin. We determined time to achieve therapeutic range (TtTR), time in therapeutic range (TiTR), their clinic al determinants, relation to SAMe-TT2R2 score, and impact on primary endpoints (composite of stroke, systemic embolic event [SEE], myocardial infarction [MI], and cardiovascular death [CVD] and composite of major + clinically relevant non-major [CRNM] bleeding).
Source: The American Journal of Cardiology - June 15, 2017 Category: Cardiology Authors: Gregory Y H Lip, Naab Al-Saady, James Jin, Ming Sun, Michael Melino, Shannon M Winters, Dmitry Zamoryakhin, Andreas Goette Source Type: research
Anticoagulation Control in Warfarin-Treated Patients Undergoing Cardioversion of Atrial Fibrillation (from the Edoxaban Versus Enoxaparin –Warfarin in Patients Undergoing Cardioversion of Atrial Fibrillation Trial)
In the Edoxaban Versus Enoxaparin –Warfarin in Patients Undergoing Cardioversion of Atrial Fibrillation (ENSURE-AF) study (NCT 02072434), edoxaban was compared with enoxaparin–warfarin in 2,199 patients undergoing electrical cardioversion of nonvalvular atrial fibrillation (AF). In this multicenter prospective randomized open bl inded end-point trial, we analyzed patients randomized to enoxaparin–warfarin. We determined time to achieve therapeutic range (TtTR); time in therapeutic range (TiTR); their clinical determinants; relation to sex, age, medical history, treatment, tobacco use, race risk (SAMe-TT2R2) score; an...
Source: The American Journal of Cardiology - June 15, 2017 Category: Cardiology Authors: Gregory Y.H. Lip, Naab Al-Saady, James Jin, Ming Sun, Michael Melino, Shannon M. Winters, Dmitry Zamoryakhin, Andreas Goette Tags: Arrhythmias and Conduction Disturbances Source Type: research
Changes in Oral Anticoagulant Prescribing for Stroke Prevention in Patients with Atrial Fibrillation
This study aimed to compare anticoagulation practice in Australia during the pre- and post-direct oral anticoagulant (DOAC) eras. Between January 2011 and July 2015, patients with non-valvular AF (NVAF) admitted to the Royal Hobart Hospital, Tasmania, Australia, were retrospectively reviewed. The pre- and post-DOAC era cohorts included admissions from January 2011 to July 2013 and August 2013 to July 2015, respectively.
Source: The American Journal of Cardiology - July 14, 2017 Category: Cardiology Authors: Endalkachew Admassie, Leanne Chalmers, Luke R. Bereznicki Source Type: research
Effect of Preoperative β-Blocker Use on Outcomes Following Cardiac Surgery
Recent studies suggest that the use of preoperative β-blockers in cardiac surgery may not provide improved mortality rates, and may even contribute to negative clinical outcomes. We therefore assessed the role of β-blockers on several outcomes following cardiac surgery (delirium, acute kidney injury (AKI), stroke, atrial fibrillation, mortality, an d hospital length of stay (LOS)) in 4,076 patients who underwent elective coronary artery bypass grafting, coronary artery bypass grafting + valve, or valve cardiac surgery between November 1, 2009 to September 30, 2015 at Vanderbilt Medical Center.
Source: The American Journal of Cardiology - July 24, 2017 Category: Cardiology Authors: Jason B. O'Neal, Frederic T. Billings, Xulei Liu, Matthew S. Shotwell, Yafen Liang, Ashish S. Shah, Jesse M. Ehrenfeld, Jonathan P. Wanderer, Andrew D. Shaw Source Type: research
Relation of Carotid Intima-Media Thickness to Cardiovascular Events in Black Americans (From the Jackson Heart Study)
Although several prospective studies have reported independent relationships between carotid intima-media thickness (CIMT) and risk of incident cardiovascular diseases (CVD) among primarily non-African American (AA) cohorts, the utility of CIMT values for the prediction of incident coronary heart disease and stroke events in blacks remain unclear. At the baseline examination (2000 –2004) of the Jackson Heart Study (JHS), AA adults 21-94 years of age (mean 54) underwent bilateral far-wall CIMT measurement (mean 0.76 mm).
Source: The American Journal of Cardiology - July 31, 2017 Category: Cardiology Authors: Todd C. Villines, Lucy L. Hsu, Chad Blackshear, Cheryl R. Nelson, Michael Griswold Source Type: research
Meta-Analysis of Comparison of Five-Year Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients with Unprotected Left Main Coronary Artery in the Era of Drug Eluting Stents
Patients with unprotected left main coronary artery (ULMCA) disease are increasingly being treated with percutaneous coronary intervention (PCI) using drug-eluting stents (DES), but long term outcomes comparing PCI with coronary artery bypass grafting (CABG) remain limited. We performed aggregate data meta-analyses of clinical outcomes [all cause death; non-fatal myocardial infarction (MI); stroke; repeat revascularization; cardiac death and major adverse cardiac and cerebrovascular events (MACCE)] in studies comparing 5 year outcomes of PCI with DES vs.
Source: The American Journal of Cardiology - August 1, 2017 Category: Cardiology Authors: Mahin R. Khan, Waleed T. Kayani, Waqas Ahmad, Ravi S. Hira, Salim S. Virani, Ihab Hamzeh, Hani Jneid, Nasser Lakkis, Mahboob Alam Source Type: research
Relation of Diastolic Blood Pressure and Coronary Artery Calcium to Coronary Events and Outcomes (From the Multi-Ethnic Study of Atherosclerosis)
Diastolic blood pressure has a J-curve relationship with coronary heart disease and death. Because this association is thought to reflect reduced coronary perfusion at low diastolic blood pressure, we hypothesized that the J-curve would be most pronounced among persons with coronary artery calcium. Among 6,811 participants from the Multi-Ethnic Study of Atherosclerosis, we used Cox models to examine if diastolic blood pressure category is associated with coronary heart disease events, stroke, and mortality.
Source: The American Journal of Cardiology - August 8, 2017 Category: Cardiology Authors: Faisal Rahman, Mahmoud Al Rifai, Michael J. Blaha, Khurram Nasir, Matthew J Budoff, Bruce M. Psaty, Wendy S. Post, Roger S. Blumenthal, John W. McEvoy Source Type: research
Comparison of the Effectiveness and Safety of Apixaban, Dabigatran, Rivaroxaban and Warfarin in Newly Diagnosed Atrial Fibrillation
No studies have performed direct pairwise comparisons of the effectiveness and safety of warfarin and the new oral anticoagulants (NOACs) apixaban, dabigatran and rivaroxaban in atrial fibrillation (AF). Using 2013-2014 claims from a 5% random sample of Medicare beneficiaries, we identified patients newly diagnosed with AF who initiated apixaban, dabigatran, rivaroxaban, warfarin or no oral anticoagulation therapy in 2013-2014. Outcomes included the composite of ischemic stroke, systemic embolism (SE) and death, any bleeding event, gastrointestinal bleeding, intracranial bleeding, and treatment persistence.
Source: The American Journal of Cardiology - August 8, 2017 Category: Cardiology Authors: Inmaculada Hernandez, Yuting Zhang, Samir Saba Source Type: research
Effect of Preoperative Beta-Blocker Use on Outcomes Following Cardiac Surgery
Recent studies suggest that the use of preoperative β blockers in cardiac surgery may not provide improved mortality rates and may even contribute to negative clinical outcomes. We therefore assessed the role of β blockers on several outcomes after cardiac surgery (delirium, acute kidney injury [AKI], stroke, atrial fibrillation (AF), mortality, an d hospital length of stay) in 4,076 patients who underwent elective coronary artery bypass grafting, coronary artery bypass grafting + valve, or valve cardiac surgery from November 1, 2009, to September 30, 2015, at Vanderbilt Medical Center.
Source: The American Journal of Cardiology - July 24, 2017 Category: Cardiology Authors: Jason B. O'Neal, Frederic T. Billings, Xulei Liu, Matthew S. Shotwell, Yafen Liang, Ashish S. Shah, Jesse M. Ehrenfeld, Jonathan P. Wanderer, Andrew D. Shaw Source Type: research
Comparison of the Effectiveness and Safety of Apixaban, Dabigatran, Rivaroxaban, and Warfarin in Newly Diagnosed Atrial Fibrillation
No studies have performed direct pairwise comparisons of the effectiveness and safety of warfarin and the new oral anticoagulants (NOACs) apixaban, dabigatran, and rivaroxaban. Using 2013 to 2014 claims from a 5% random sample of Medicare beneficiaries, we identified patients newly diagnosed with atrial fibrillation who initiated apixaban, dabigatran, rivaroxaban, warfarin, or no oral anticoagulation therapy in 2013 to 2014. Outcomes included the composite of ischemic stroke, systemic embolism (SE) and death, any bleeding event, gastrointestinal bleeding, intracranial bleeding, and treatment persistence.
Source: The American Journal of Cardiology - August 8, 2017 Category: Cardiology Authors: Inmaculada Hernandez, Yuting Zhang, Samir Saba Source Type: research
Meta-Analysis of Comparison of 5-Year Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Unprotected Left Main Coronary Artery in the Era of Drug-eluting Stents
Patients with unprotected left main coronary artery (ULMCA) disease are increasingly being treated with percutaneous coronary intervention (PCI) using drug-eluting stents (DES), but long-term outcomes comparing PCI with coronary artery bypass grafting (CABG) remain limited. We performed aggregate data meta-analyses of clinical outcomes (all-cause death, nonfatal myocardial infarction, stroke, repeat revascularization, cardiac death, and major adverse cardiac and cerebrovascular events) in studies comparing 5-year outcomes of PCI with DES versus CABG in patients with ULMCA disease.
Source: The American Journal of Cardiology - August 1, 2017 Category: Cardiology Authors: Mahin R. Khan, Waleed T. Kayani, Waqas Ahmad, Ravi S. Hira, Salim S. Virani, Ihab Hamzeh, Hani Jneid, Nasser Lakkis, Mahboob Alam Source Type: research
Comparison of Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Chronic Kidney Disease
There are few data comparing outcomes of transcatheter aortic valve implantation (TAVI) vs. surgical aortic valve replacement (SAVR) in patients with chronic kidney disease (CKD). In this retrospective cohort study using the National Inpatient Sample 2011 – 2014, we included a total of 2820 TAVI and 4054 SAVR procedures, representative of 14,039 TAVI and 19,835 SAVR procedures nationally. Co-primary outcomes were in-hospital mortality, acute kidney injury (AKI), dialysis-requiring AKI, and post-operative stroke.
Source: The American Journal of Cardiology - October 31, 2017 Category: Cardiology Authors: Nilay Kumar, Rohan Khera, Neetika Garg, Justin B. Echouffo-Tcheugui, Anand Venkatraman, Ambarish Pandey, Deepak L. Bhatt Source Type: research
Frequency of Electrocardiographic Abnormalities in Patients with Psoriasis
Psoriasis is a chronic inflammatory disease associated with cardiovascular disease, e.g., myocardial infarction, stroke, cardiovascular death, and arrhythmias. The resting electrocardiogram (ECG) may carry prognostic information but limited evidence is available of ECG findings in subjects with psoriasis. The ECG was compared between 1,131 individuals with self-reported psoriasis and 18,397 controls participating in the Danish General Suburban Population Study. The mean heart rate was marginally increased in patients with psoriasis (66 ± 11 vs.
Source: The American Journal of Cardiology - February 4, 2018 Category: Cardiology Authors: Peter Riis Hansen, Christian Rimer Juhl, Jonas Lynggaard Isaksen, Gregor Borut Jemec, Christina Ellervik, J ørgen Kim Kanters Source Type: research
Patent Foramen Ovale Closure - When Number Needed to Treat and Number Needed to Harm Do Not Tell the Whole Story
We read with interest the thorough meta-analysis of Ando at al. (1) comparing patent foramen ovale (PFO) closure against medical therapy. The authors showed that PFO closure reduced the risk of recurrent stroke by 58% with a number needed to treat (NNT) of 38. PFO closure plus medical therapy, however, conferred a significant increase in risk of newly detected atrial fibrillation (AF) with a number needed to harm (NNH) of 29. With 4.3%, the prevalence of newly detected AF after PFO closure was similar to the one of 3.7% (95% CI, 2.9% –4.6%) in a recent large retrospective cohort study of 1887 patients (2).
Source: The American Journal of Cardiology - February 13, 2018 Category: Cardiology Authors: Franz H. Messerli, Bernhard Meier Source Type: research
Impact of Balloon Pre-Dilatation on Hemodynamics and Outcomes after Transcatheter Aortic Valve Implantation with the Self-Expanding CoreValve Prosthesis
The impact of pre-dilatation on prosthesis hemodynamics and clinical outcomes of subjects undergoing transcatheter aortic valve implantation (TAVI) with a self-expanding prosthesis remains unclear. Two thousand seven hundred twenty-one subjects from the extreme- and high-risk CoreValve Continued Access Study (CAS) were included in the analysis. Subjects who underwent pre-dilatation (Pre-Dil) prior to TAVI were compared with those who received TAVI with no Pre-Dil. Clinical outcomes included death, stroke, myocardial infarction, acute kidney injury, and new permanent pacemaker implantation.
Source: The American Journal of Cardiology - March 1, 2018 Category: Cardiology Authors: Toby Rogers, Ron Waksman, J. Kevin Harrison, G. Michael Deeb, Angie Zhang, James B. Hermiller, Jeffrey J. Popma, Michael J. Reardon Source Type: research
