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Source: The American Journal of Cardiology
Education: Study
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Total 366 results found since Jan 2013.
Usefulness of a Combination of Monocyte Chemoattractant Protein-1, Galectin-3, and N-Terminal Probrain Natriuretic Peptide to Predict Cardiovascular Events in Patients With Coronary Artery Disease
Patients with coronary artery disease may develop not only ischemic events but also heart failure and death due to previous myocardial damage. The purpose of this study was to test the prognostic value of a panel of plasma biomarkers related to vascular (monocyte chemoattractant protein-1 [MCP-1] and soluble tumor necrosis factor–like weak inducer of apoptosis) and myocardial damage (galectin-3, N-terminal fragment of brain natriuretic peptide [NT-proBNP], and neutrophil gelatinase–associated lipocalin) in 706 patients with chronic coronary artery disease followed for 2.2 ± 0.99 years. Secondary outcomes were the inc...
Source: The American Journal of Cardiology - November 11, 2013 Category: Cardiology Authors: José Tuñón, Luis Blanco-Colio, Carmen Cristóbal, Nieves TarÃn, Javier Higueras, Ana Huelmos, JoaquÃn Alonso, Jesús Egido, Dolores Asensio, Óscar Lorenzo, Ignacio MahÃllo-Fernández, Fernando RodrÃguez-Artalejo, Jerónimo Farré, José Luis Martà Tags: Coronary Artery Disease Source Type: research
Meta-Analysis of Gender Differences in Residual Stroke Risk and Major Bleeding in Patients With Nonvalvular Atrial Fibrillation Treated With Oral Anticoagulants
In conclusion, women with AF treated with warfarin have a greater residual risk of CVA/SE and an equivalent major bleeding risk, whereas those treated with NOAC agents deemed superior to warfarin are at equivalent residual risk of CVA/SE and less major bleeding risk compared with men. These results suggest an increased net clinical benefit of NOAC agents compared with warfarin in treating women with AF.
Source: The American Journal of Cardiology - November 14, 2013 Category: Cardiology Authors: Samir B. Pancholy, Parikshit S. Sharma, Dipti S. Pancholy, Tejas M. Patel, David J. Callans, Francis E. Marchlinski Tags: Arrhythmias and Conduction Disturbances Source Type: research
Meta-Analysis of Global Left Ventricular Function Comparing Multidetector Computed Tomography With Cardiac Magnetic Resonance Imaging
We compare the diagnostic accuracy of multidetector row computed tomography (MDCT) to cardiac magnetic resonance imaging (CMR) for evaluating global left ventricular function. We systematically searched PubMed, CINAHL, Cochrane CENTRAL, Scopus, and the Web of Science databases for studies published between 1966 to January 2013 that compared left ventricle (LV) volumes, ejection fraction (EF) and LV mass measured by MDCT and CMR. We performed meta-analyses and used random-effects model with inverse variance weighting test to determine the overall bias and limits of agreement of LV end-diastolic volume, end-systolic volume, ...
Source: The American Journal of Cardiology - November 27, 2013 Category: Cardiology Authors: Abhishek Sharma, Andrew J. Einstein, Ajay Vallakati, Armin Arbab-Zadeh, Debabrata Mukherjee, Edgar Lichstein Tags: Methods Source Type: research
Long-Term Prognostic Value and Serial Changes of Plasma N-Terminal Prohormone B-Type Natriuretic Peptide in Patients Undergoing Transcatheter Aortic Valve Implantation
The objectives of this study were to evaluate the baseline values and serial changes of N-terminal prohormone B-type natriuretic peptide (NT-proBNP) after TAVI, its related factors, and prognostic value. A total of 333 consecutive patients were included, and baseline, procedural, and follow-up (median 20Â months, interquartile range 9 to 36) data were prospectively collected. Systematic NT-proBNP measurements were performed at baseline, hospital discharge, 1, 6, and 12Â months, and yearly thereafter. Baseline NT-proBNP values were elevated in 86% of the patients (median 1,692 pg/ml); lower left ventricular ejection fractio...
Source: The American Journal of Cardiology - December 16, 2013 Category: Cardiology Authors: Henrique B. Ribeiro, Marina Urena, Florent Le Ven, Luis Nombela-Franco, Ricardo Allende, Marie-Annick Clavel, Abdellaziz Dahou, Mélanie Côté, Jerôme Laflamme, Louis Laflamme, Hugo DeLarochellière, Robert DeLarochellière, Daniel Doyle, Éric Dumont, Tags: Valvular Heart Disease Source Type: research
Impact of Gender on the Prognosis of Patients With Nonvalvular Atrial Fibrillation
Treatment guidelines for atrial fibrillation (AF) used in Western countries describe female gender as a risk factor for thromboembolic events in patients with nonvalvular AF (NVAF). The present study aimed to determine the impact of gender on prognosis of Japanese patients with NVAF. A subanalysis of 7,406 patients with NVAF (mean age 70 years) who were followed-up prospectively for 2 years was performed using data from the J-RHYTHM registry. The primary end points were thromboembolic events, major hemorrhaging, total mortality, and cardiovascular mortality. Compared with male subjects (n = 5,241), female subjects (n =...
Source: The American Journal of Cardiology - December 26, 2013 Category: Cardiology Authors: Hiroshi Inoue, Hirotsugu Atarashi, Ken Okumura, Takeshi Yamashita, Hideki Origasa, Naoko Kumagai, Masayuki Sakurai, Yuichiro Kawamura, Isao Kubota, Kazuo Matsumoto, Yoshiaki Kaneko, Satoshi Ogawa, Yoshifusa Aizawa, Masaomi Chinushi, Itsuo Kodama, Eiichi W Tags: Arrhythmias and Conduction Disturbances Source Type: research
Prognosis of Patients With Stable Coronary Artery Disease (from the CORONOR Study)
In conclusion, the mortality rate of patients with stable CAD in modern clinical practice is similar to that of the general population and is mostly due to noncardiovascular causes.
Source: The American Journal of Cardiology - January 15, 2014 Category: Cardiology Authors: Christophe Bauters, Michel Deneve, Olivier Tricot, Thibaud Meurice, Nicolas Lamblin, CORONOR Investigators Tags: Coronary Artery Disease Source Type: research
Association of CHADS2, CHA2DS2-VASc, and R2CHADS2 Scores With Left Atrial Dysfunction in Patients With Coronary Heart Disease (from the Heart and Soul Study)
This study investigated the association between the CHADS2 score and LA function. We performed resting transthoracic echocardiography in 970 patients with stable coronary heart disease and normal ejection fraction and calculated baseline LA functional index (LAFI) using a validated formula: (LA emptying fraction × left ventricular outflow tract velocity time integral)/LA end-systolic volume indexed to body surface area. We performed regression analyses to evaluate the association between risk scores and LAFI. Among 970 subjects, mean CHADS2 was 1.7 ± 1.2. Mean LAFI decreased across tertiles of CHADS2 (42.8 ± 18.1, 37.8...
Source: The American Journal of Cardiology - January 16, 2014 Category: Cardiology Authors: Farnaz Azarbal, Christine C. Welles, Jonathan M. Wong, Mary A. Whooley, Nelson B. Schiller, Mintu P. Turakhia Tags: Arrhythmias and Conduction Disturbances Source Type: research
Prevalence of Memory Disorders in Ambulatory Patients Aged ≥70 Years With Chronic Heart Failure (from the EFICARE Study)
The aim of this multicenter observational study conducted in France was to determine the prevalence of memory impairment in ambulatory patients aged ≥70 years with chronic heart failure (HF). Two hundred ninety-one cardiologists recruited 912 ambulatory patients with HF (mean age 79.2 ± 5.8 years) from January to November 2009. Memory was evaluated by the delayed-recall Memory Impairment Screen (MIS-D). Memory impairment was defined as MIS-D score ≤6 and severe memory impairment as MIS-D score ≤4. HF was diagnosed 4.4 ± 4.8 years earlier and mean left ventricular ejection fraction was 43.6 ± 12.0%. Memory impai...
Source: The American Journal of Cardiology - January 16, 2014 Category: Cardiology Authors: Olivier Hanon, Jean-Sébastien Vidal, Pascal de Groote, Michel Galinier, Richard Isnard, Damien Logeart, Michel Komajda Tags: Heart Failure Source Type: research
Safety of Short-Term Use of Dabigatran or Rivaroxaban for Direct-Current Cardioversion in Patients With Atrial Fibrillation and Atrial Flutter
In conclusion, the use of short-term dabigatran or rivaroxaban therapy for DCCV of AF appears safe.
Source: The American Journal of Cardiology - February 3, 2014 Category: Cardiology Authors: Ajay Yadlapati, Christopher Groh, Rod Passman Tags: Arrhythmias and Conduction Disturbances Source Type: research
Left Atrial Remodeling in Hypertrophic Cardiomyopathy and Susceptibility Markers for Atrial Fibrillation Identified by Cardiovascular Magnetic Resonance
This study characterizes left atrial (LA) structural and functional parameters to establish markers predictive of AF risk, using cardiovascular magnetic resonance (CMR) imaging. We studied 427 consecutive patients with HC in sinus rhythm with CMR (age 44 ± 18 years), including 41 who developed clinically overt AF after study entry (2.6 ± 2.1 years), 49 patients with AF before CMR, 337 patients with HC but without AF, and 244 normal controls. LA chamber was assessed for absolute and indexed end-diastolic volume (LAEDV), end-systolic volume, and percent ejection fraction (LAEF). In the 41 prospectively studied patients w...
Source: The American Journal of Cardiology - February 3, 2014 Category: Cardiology Authors: Barry J. Maron, Tammy S. Haas, Martin S. Maron, John R. Lesser, Joseph A. Browning, Raymond H. Chan, Iacopo Olivotto, Ross F. Garberich, Robert S. Schwartz Tags: Cardiomyopathy Source Type: research
Impact of Multiple Complex Plaques on Short- and Long-Term Clinical Outcomes in Patients Presenting With ST-Segment Elevation Myocardial Infarction (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction HORIZONS-AMI Trial)
It is not known whether the extent and severity of nonculprit coronary lesions correlate with outcomes in patients with ST-segment elevation myocardial infarction (STEMI) referred for primary percutaneous coronary intervention (PCI). We sought to quantify complex plaques in patients with STEMI referred for primary PCI and to determine their effect on short- and long-term clinical outcomes by examining the core laboratory database for plaque analysis from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction study. Baseline demographic, angiographic, and procedural details were compared b...
Source: The American Journal of Cardiology - March 3, 2014 Category: Cardiology Authors: Ellen C. Keeley, Roxana Mehran, Sorin J. Brener, Bernhard Witzenbichler, Giulio Guagliumi, Dariusz Dudek, Ran Kornowski, Ovidiu Dressler, Martin Fahy, Ke Xu, Cindy L. Grines, Gregg W. Stone Tags: Coronary Artery Disease Source Type: research
Impact of Dual Antiplatelet Therapy on Outcomes Among Aspirin-Resistant Patients Following Coronary Artery Bypass Grafting
This study was designed to define the impact of dual antiplatelet therapy (dAPT) on clinical outcomes among aspirin-resistant patients who underwent coronary artery surgery. We randomly assigned 219 aspirin-resistant patients according to multiple electrode aggregometry to receive clopidogrel (75Â mg) plus aspirin (300Â mg) or aspirin-monotherapy (300Â mg). The primary end point was a composite outcome of all-cause death, nonfatal myocardial infarction, stroke, or cardiovascular hospitalization assessed at 6Â months postoperatively. The primary end point occurred in 6% of patients assigned to dAPT and 10% of patients rando...
Source: The American Journal of Cardiology - March 3, 2014 Category: Cardiology Authors: Hrvoje Gasparovic, Mate Petricevic, Tomislav Kopjar, Zeljko Djuric, Lucija Svetina, Bojan Biocina Tags: Coronary Artery Disease Source Type: research
Relation of Interatrial Block to New-Onset Atrial Fibrillation in Patients With Chagas Cardiomyopathy and Implantable Cardioverter-Defibrillators
Chagas cardiomyopathy is an endemic disease in Latin America. A significant proportion of patients develop atrial fibrillation (AF), which may result in stroke and increased morbidity or mortality. Interatrial block (IAB) has been associated with the development of AF in different clinical scenarios. The aim of our study was to determine whether IAB can predict new-onset AF in patients with Chagas cardiomyopathy and implantable cardioverter-defibrillators (ICDs). We conducted a retrospective study of patients with Chagas cardiomyopathy and ICDs from 14 centers in Latin America. Demographics, clinical, and device follow-up ...
Source: The American Journal of Cardiology - March 3, 2014 Category: Cardiology Authors: Andres Enriquez, Diego Conde, Francisco Femenia, Antoni Bayés de Luna, Antonio Ribeiro, Claudio Muratore, Mariana Valentino, Enrique Retyk, Nestor Galizio, Wilma M. Hopman, Adrian Baranchuk Tags: Cardiomyopathy Source Type: research
Comparison of In-Hospital Outcomes for Beta-Blocker Use Versus Non–Beta Blocker Use in Patients Presenting With Cocaine-Associated Chest Pain
In conclusion, no differences in outcomes were observed between patients treated versus not treated with β-blocker therapy in the setting of cocaine-related chest pain.
Source: The American Journal of Cardiology - March 17, 2014 Category: Cardiology Authors: Zaher Fanari, Kevin K. Kennedy, Michael J. Lim, Abhay A. Laddu, Joshua M. Stolker Tags: Coronary Artery Disease Source Type: research
Impact of Female Gender on Bleeding Complications After Transradial Coronary Intervention (from the Korean Transradial Coronary Intervention Registry)
This study aimed to investigate the impact of gender on clinical outcomes and bleeding complications after transradial coronary intervention (TRI). The Korean TRI registry is a retrospective multicenter registry with 4,890 patients who underwent percutaneous coronary intervention in 2009 at 12 centers. To compare clinical outcomes and bleeding complications between the male and female groups, we performed a propensity score matching in patients who received TRI. A total of 1,194 patients (597 in each group) were studied. The primary outcome was 1-year major adverse cardiac events, including all-cause mortality, myocardial ...
Source: The American Journal of Cardiology - April 3, 2014 Category: Cardiology Authors: Jeoung-Sook Shin, Seung-Jea Tahk, Hyoung-Mo Yang, Myeong-Ho Yoon, So-Yeon Choi, Byoung-Joo Choi, Hong-Seok Lim, You-Hong Lee, Kyoung-Woo Seo, Se-Jun Park, Yong-Woo Choi, Junghan Yoon, Young Jin Youn, Byung Ryeol Cho, Kwang Soo Cha, Kyoo Rok Han, Min Su Hy Tags: Coronary Artery Disease Source Type: research
