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Source: The American Journal of Cardiology
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Total 366 results found since Jan 2013.

Development and Validation of a Cardiovascular Risk Assessment Model in Patients With Established Coronary Artery Disease
In conclusion, in patients with established coronary artery disease, the risk of cardiovascular mortality during longer term follow-up can be adequately predicted using the clinical characteristics available at baseline. However, the prediction of nonfatal outcomes, both separately and combined with fatal outcomes, poses major challenges for clinicians and model developers.
Source: The American Journal of Cardiology - April 3, 2013 Category: Cardiology Authors: Linda Battes, Rogier Barendse, Ewout W. Steyerberg, Maarten L. Simoons, Jaap W. Deckers, Daan Nieboer, Michel Bertrand, Roberto Ferrari, Willem J. Remme, Kim Fox, Johanna J.M. Takkenberg, Eric Boersma, Isabella Kardys Tags: Coronary Artery Disease Source Type: research

Frequency, Determinants and Prognostic Implications of Infectious Complications After Transcatheter Aortic Valve Implantation
This study included 298 consecutive patients from 2 centers who underwent TAVI from November 2005 to November 2011. IHI during the hospital stay was defined on the basis of symptoms and signs assessed by the attending physician in the cardiac care unit or medium care unit in combination with all technical examinations performed to confirm infection. IHI after TAVI was observed in 58 patients (19.5%): urinary tract infections in 25 patients (43.1%), pneumonia in 12 patients (20.7%), and access-site infections in 7 patients (12.1%). In 12 patients (20.7%), the site of infection could not be determined, and 2 patients (3.4%) ...
Source: The American Journal of Cardiology - April 8, 2013 Category: Cardiology Authors: Robert M.A. van der Boon, Rutger-Jan Nuis, Luis M. Benitez, Nicolas M. Van Mieghem, Sergio Perez, Lidsa Cruz, Robert-Jan van Geuns, Patrick W. Serruys, Ron T. van Domburg, Antonio E. Dager, Peter P.T. de Jaegere Tags: Valvular Heart Disease Source Type: research

Comparison of Characteristics and Short-Term Outcome From Fungal Infective Endocarditis in Prosthetic Valve Endocarditis Versus Native Valve Endocarditis
In conclusion, fungal IE is associated with high mortality and recurrence rates. Surgery performed in selected cases may improve the outcomes, but the recurrence rate remains high.
Source: The American Journal of Cardiology - April 5, 2013 Category: Cardiology Authors: Xiao-lu Sun, Jian Zhang, Guo-gan Wang, Xiao-feng Zhuang, Yan-min Yang, Jun Zhu, Hui-qiong Tan, Li-tian Yu Tags: Valvular Heart Disease Source Type: research

Left Ventricular Diastolic Function and Long-Term Outcomes in Patients With Normal Exercise Echocardiographic Findings
The objective of the present study was to determine whether diastolic dysfunction (DD) is associated with outcomes in the absence of myocardial ischemia. We studied 2,835 patients undergoing exercise echocardiography from January 2006 through December 2006 who had normal systolic function (ejection fraction ≥50%) and an absence of exercise-induced wall motion abnormalities. Diastolic function was graded as normal, mild DD, or moderate to severe DD. Medical records review and patient contact were undertaken to determine mortality, cardiovascular events (i.e., death, myocardial infarction, or stroke), incident heart failur...
Source: The American Journal of Cardiology - April 22, 2013 Category: Cardiology Authors: S. Michael Gharacholou, Christopher G. Scott, Paul Y. Takahashi, Vuyisile T. Nkomo, Robert B. McCully, Nowell M. Fine, Patricia A. Pellikka Tags: Coronary Artery Disease Source Type: research

Comparison of Benazepril Plus Amlodipine or Hydrochlorothiazide in High-Risk Patients With Hypertension and Coronary Artery Disease
In conclusion, our findings suggest that the combination of B+A should be preferentially used for older patients with high-risk, stage 2 hypertension.
Source: The American Journal of Cardiology - April 15, 2013 Category: Cardiology Authors: George Bakris, Alexandros Briasoulis, Bjorn Dahlof, Kenneth Jamerson, Michael A. Weber, Roxzana Y. Kelly, Allen Hester, Tsushung Hua, Dion Zappe, Bertram Pitt, ACCOMPLISH Investigators Tags: Systemic Hypertension Source Type: research

Comparison of the Efficacy and Safety of Two Rivaroxaban Doses in Acute Coronary Syndrome (from ATLAS ACS 2–TIMI 51)
In conclusion, the 2 doses of rivaroxaban reduced cardiovascular events in patients with recent acute coronary syndromes treated with antiplatelet therapies; however, the 2.5-mg dose was associated with lower mortality and fewer bleeding complications than the 5-mg dose. Thus, the addition of rivaroxaban 2.5 mg twice daily offers a more favorable balance of efficacy and safety in patients with recent acute coronary syndromes.
Source: The American Journal of Cardiology - May 28, 2013 Category: Cardiology Authors: Jessica L. Mega, Eugene Braunwald, Stephen D. Wiviott, Sabina A. Murphy, Alexei Plotnikov, Nina Gotcheva, Mikhail Ruda, C. Michael Gibson Tags: Coronary Artery Disease Source Type: research

Comparison by Meta-Analysis of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With a Mean Age of ≥70 Years
A paucity of published data evaluating the outcomes of older patients (age ≥70 years) undergoing revascularization for unprotected left main coronary artery disease is available. We performed aggregate data meta-analyses of the clinical outcomes (all-cause mortality, nonfatal myocardial infarction, stroke, repeat revascularization, and major adverse cardiac and cerebrovascular events at 30 days and 12 and 22 months) in studies comparing percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in patients with a mean age of ≥70 years and unprotected left main coronary artery disease. A compre...
Source: The American Journal of Cardiology - May 31, 2013 Category: Cardiology Authors: Mahboob Alam, Salim S. Virani, Saima A. Shahzad, Sahar Siddiqui, Khaleeq H. Siddiqui, Shahzad A. Mumtaz, Neal S. Kleiman, Joseph S. Coselli, Nasser M. Lakkis, Hani Jneid Tags: Coronary Artery Disease Source Type: research

Efficacy of the CHADS2 Scoring System to Assess Left Atrial Thrombogenic Milieu Risk Before Cardioversion of Non-Valvular Atrial Fibrillation
In this study, data from 2,369 consecutive patients in whom transesophageal echocardiography was performed for screening before direct-current cardioversion from 1999 to 2008 were analyzed. Left atrial (LA) or LA appendage (LAA) thrombogenic milieu (spontaneous echo contrast, sludge, and thrombus) was investigated. The results were correlated with CHADS2 score findings. The mean age was 66 ± 13 years, and the ratio of men to women was 2.2:1. CHADS2 scores of 0, 1, 2, 3, 4, 5 and 6 were present in 11%, 25%, 30%, 22%, 8%, 3%, and 1% of the studies, respectively. The prevalence of LA or LAA sludge or thrombus increased with ...
Source: The American Journal of Cardiology - May 31, 2013 Category: Cardiology Authors: Hirad Yarmohammadi, Tristan Klosterman, Gaganpreet Grewal, M. Chadi Alraies, Brandon C. Varr, Bruce Lindsay, Andrew O. Zurick, Kevin Shrestha, W.H. Wilson Tang, Mandeep Bhargava, Allan L. Klein Tags: Arrhythmias and Conduction Disturbances Source Type: research

Angina Pectoris or Myocardial Infarctions, Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia, and Paradoxical Emboli
In conclusion, we suggest that in patients with untreated PAVMs, cardiac ischemia can occur because of a paradoxical embolus through PAVMs to a coronary artery.
Source: The American Journal of Cardiology - May 23, 2013 Category: Cardiology Authors: Katherine Clark, Reed E. Pyeritz, Scott O. Trerotola Tags: Miscellaneous Source Type: research

Relation of Subclinical Coronary Artery Atherosclerosis to Cerebral White Matter Disease in Healthy Subjects From Families With Early-Onset Coronary Artery Disease
White matter disease (WMD) of the brain is associated with incident stroke. Similarly, subclinical calcified coronary artery plaque has been associated with incident coronary artery disease (CAD) events. Although atherogenesis in both vascular beds may share some common mechanisms, the extent to which subclinical CAD is associated with WMD across age ranges in subjects with a family history of early-onset CAD remains unknown. We screened 405 apparently healthy participants in the Genetic Study of Atherosclerotic Risk for CAD risk factors and for the presence of noncalcified and calcified coronary plaque using dual-source m...
Source: The American Journal of Cardiology - June 5, 2013 Category: Cardiology Authors: Brian G. Kral, Paul Nyquist, Dhananjay Vaidya, David Yousem, Lisa R. Yanek, Elliot K. Fishman, Lewis C. Becker, Diane M. Becker Tags: Coronary Artery Disease Source Type: research

Incidence and Outcome of High On-Treatment Platelet Reactivity in Patients With Non-ST Elevation Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention (from the VIP VerifyNow and Inhibition of Platelet Reactivity Study)
In conclusion, 1/3 of patients with acute coronary syndromes who underwent percutaneous coronary intervention and stenting showed high on-treatment RPR on bedside monitoring. They had a worse prognosis, but the level of platelet inhibition was not independently associated with the incidence of ischemic or bleeding events.
Source: The American Journal of Cardiology - June 7, 2013 Category: Cardiology Authors: Francesco Saia, Massimiliano Marino, Gianluca Campo, Marco Valgimigli, Paolo Guastaroba, Nevio Taglieri, Stefano Tondi, Antonio Manari, Vincenzo Guiducci, Pietro Sangiorgio, Elisabetta Varani, Paolo Magnavacchi, Rossana De Palma, Antonio Marzocchi Tags: Coronary Artery Disease Source Type: research

A Meta-Analysis of Mortality and Major Adverse Cardiovascular and Cerebrovascular Events Following Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement for Severe Aortic Stenosis
The purpose of this meta-analysis was to compare postprocedural mortality and major adverse cardiovascular and cerebrovascular events between transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) for severe aortic stenosis. Seventeen studies (n = 4,659) comparing TAVI (n = 2,267) and SAVR (n = 2,392) were included. End points were baseline logistic European System for Cardiac Operative Risk Evaluation score, all-cause mortality, cardiovascular mortality, myocardial infarction, stroke, transient ischemic attack, and major bleeding events. Mean differences or risk ratios with 95% conf...
Source: The American Journal of Cardiology - June 6, 2013 Category: Cardiology Authors: Hemang B. Panchal, Vatsal Ladia, Saurabh Desai, Tejaskumar Shah, Vijay Ramu Tags: Valvular Heart Disease Source Type: research

Accuracy and Feasibility of Simplified Doppler-Based Left Ventricular Ejection Fraction
Calculation of left ventricular (LV) ejection fraction (EF) by Doppler stroke volume and end-diastolic volume (EDV) derived from LV diastolic diameter (LVIDD) could be reliable and feasible in clinical practice. In subjects with a wide range of LV volumes and EFs, magnetic resonance imaging (MRI) was used to evaluate the accuracy of common formulas (Teichholz and Z method) to estimate EDV from LVIDD (EDVTeich; EDVZ) versus volumetric EDV. The accuracy of simplified Doppler-EF was tested in a separate study sample versus real-time 3-dimensional (RT3D) echocardiography and versus bidimensional Simpson's method. A new equatio...
Source: The American Journal of Cardiology - June 10, 2013 Category: Cardiology Authors: Vittorio Palmieri, Fiorenzo Manganelli, Cesare Russo, Biagio Gagliardi, Salvatore Pezzullo, Giuliano Gagliardi, Giuseppe Rosato, Carmelo Lombardi Tags: Methods Source Type: research

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