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Source: Thrombosis and Haemostasis
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Total 312 results found since Jan 2013.
D-dimer and the risk of hypertension: The REasons for Geographic And Racial Differences in Stroke Cohort Study
CONCLUSION: D-dimer concentration reflects pathophysiology related to the development of hypertension. Specific mechanisms require further study and may involve adiposity.PMID:36760775 | PMC:PMC9903654 | DOI:10.1016/j.rpth.2022.100016
Source: Thrombosis and Haemostasis - February 10, 2023 Category: Hematology Authors: Debora Kamin Mukaz Boyi Guo D Leann Long Suzanne E Judd Timothy B Plante Leslie A McClure Alisa S Wolberg Neil A Zakai George Howard Mary Cushman Source Type: research
Stroke and myocardial infarction in patients with abdominal aortic aneurysms and new-onset atrial fibrillation
Conclusion Cardiovascular prognosis has improved in patients with prevalent AAA disease and new-onset AF in concordance with optimization of antithrombotic therapy over time. A diagnosis of AF conferred residual risk of stroke and myocardial infarction.PMID:36626930 | DOI:10.1055/a-2009-8954
Source: Thrombosis and Haemostasis - January 10, 2023 Category: Hematology Authors: Chalotte Winther Winther Nicolajsen Peter Br ønnum Nielsen Martin Jensen Nikolaj Eldrup Torben Bjerregaard Larsen Gregory Yh Lip Samuel Z Goldhaber Mette S øgaard Source Type: research
Expression of microRNA Predicts Cardiovascular Events in Patients with Stable Coronary Artery Disease
CONCLUSIONS: Among patients with CAD, adding miR-223-3p expression to traditional cardiovascular risk factors may improve prediction of cardiovascular events, particularly ST. Clinical trials confirming these findings are warranted.PMID:36603835 | DOI:10.1055/s-0042-1760258
Source: Thrombosis and Haemostasis - January 5, 2023 Category: Hematology Authors: Oliver Buchhave Pedersen Erik Lerkevang Grove Peter H Nissen Sanne B øjet Larsen Leonardo Pasalic Steen Dalby Kristensen Anne-Mette Hvas Source Type: research
Severe left atrial spontaneous echo contrast in non-valvular atrial fibrillation: Clinical characteristics and impact on ischemic risk post-ablation
Conclusions Higher BNP, ESR, LAd/∆LVED were the independent predictors for severe SEC. Severe SEC were associated with higher peri-procedural and long-term ischemic risks. ESR and LAd/∆LVED, as indicators of hematological and hemodynamic change, seemed helpful in identifying NVAF patients prone to developing severe SEC.PMID:36402133 | DOI:10.1055/a-1983-0516
Source: Thrombosis and Haemostasis - November 19, 2022 Category: Hematology Authors: Hao Wang Siqi Xi Jindong Chen Liang Zhao Tian Gan Ben He Source Type: research
Alteplase or tenecteplase for thrombolysis in ischemic stroke: An illustrated review
Res Pract Thromb Haemost. 2022 Sep 20;6(6):e12795. doi: 10.1002/rth2.12795. eCollection 2022 Aug.ABSTRACTIntravenous thrombolysis is a standard of care treatment for patients with acute ischemic stroke. Tissue plasminogen activator (tPA) has been the main thrombolytic agent used since the publication of the seminal National Institutes of Neurological Disorders and Stroke trial in 1995. There is now mounting evidence to support the routine use of Tenecteplase (TNK) to treat acute ischemic stroke. TNK is a genetically modified tPA with higher fibrin specificity, longer half-life, and reduced systemic coagulopathy. In this il...
Source: Thrombosis and Haemostasis - October 3, 2022 Category: Hematology Authors: Annie Zhu Phavalan Rajendram Eric Tseng Shelagh B Coutts Amy Y X Yu Source Type: research
Hyperhomocysteinemia in cardiovascular diseases: revisiting observational studies and clinical trials
In conclusion, revisiting observational studies and clinical trials suggests that cardiovascular patients should be screened for hyperhomocysteinemia, when no other risk factor is found. Patients with intermediate/major hyperhomocysteinemia should be properly assessed and treated for vitamin B deficiencies and inherited disorders according to current guidelines. Further trials are needed to assess the lowering homocysteine effect according to hyperhomocysteinemia categories at baseline.PMID:36170884 | DOI:10.1055/a-1952-1946
Source: Thrombosis and Haemostasis - September 28, 2022 Category: Hematology Authors: Jean-Louis Gueant Rosa-Maria Gueant-Rodriguez Abderrahim Oussalah Stephane Zuily Irwin Rosenberg Source Type: research
Essen Stroke Risk Score Predicts Clinical Outcomes in Heart Failure Patients With Preserved Ejection Fraction: Evidence From the TOPCAT trial
This study sought to determine whether the Essen Stroke Risk Score (ESRS) could predict the risks of adjudicated clinical outcomes in patients with Heart failure with preserved ejection fraction (HFpEF) from the TOPCAT trial. Of 3,441 HFpEF patients with a mean follow-up of 3.3 years, the risk of stroke ranged from 0.32% per year at an ESRS of 1-2 points to 1.71% per year at a score of ≥6 points. Each point increase in ESRS was associated with increased risks of stroke (HR=1.33 [95% CI 1.16-1.53]) with a C-index of 0.68, as well as myocardial infarction (HR=1.60 [95% CI 1.40-1.83]; C-index, 0.75), HF hospitalization (HR=...
Source: Thrombosis and Haemostasis - August 29, 2022 Category: Hematology Authors: Wengen Zhu Yalin Cao Min Ye Hulin Huang Yuzhong Wu Jianyong Ma Yugang Dong Xiao Liu Chen Liu Gregory Yh Lip Source Type: research
NO/cGMP/PKG pathway in platelets:the therapeutic potential of PDE5 inhibitors in platelet disorders
J Thromb Haemost. 2022 Aug 11. doi: 10.1111/jth.15844. Online ahead of print.ABSTRACTPlatelets are the "guardians" of the blood circulatory system. At sites of vessel injury, they ensure hemostasis and promote immunity and vessel repair. However, their uncontrolled activation is one of the main drivers of thrombosis. To keep circulating platelets in a quiescent state, the endothelium releases platelet antagonists including nitric oxide (NO) that acts by stimulating the intracellular receptor guanylyl cyclase (GC). The latter produces the second messenger cyclic guanosine-3',5'-monophosphate (cGMP) that inhibits platelet ac...
Source: Thrombosis and Haemostasis - August 11, 2022 Category: Hematology Authors: Anisa Degjoni Federica Campolo Lucia Stefanini Mary Anna Venneri Source Type: research
