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Fatigue in stroke survivors: a 5-year follow-up of the Fall study of Gothenburg
In conclusion, half of the participants reported PSF 5 years after index stroke and higher body mass index was identified as a predictor. The findings from this study are important for healthcare professionals, for planning health-related efforts and rehabilitation of stroke survivors.ClinicalTrials.gov, Identifier NCT02264470.
Source: Journal of Neurology - September 20, 2023 Category: Neurology Source Type: research

A typology of cerebral small vessel disease based on imaging markers
ConclusionThe study confirmed the existence of different SVD types with different relationships to stroke outcome. EPVS and WMH were identified as imaging features of presumably early progression. The number of microbleeds and WMH severity appear to be promising biomarkers for distinguishing clinical subgroups. Further understanding of SVD progression might require consideration of refined SVD features, e.g., for EPVS and type of lacunes.
Source: Journal of Neurology - September 20, 2023 Category: Neurology Source Type: research

Frequency and predictors of poststroke epilepsy after mechanical thrombectomy for large vessel occlusion stroke: results from a multicenter cohort study
ConclusionIn our study, patients with large vessel occlusion stroke receiving MT had a 9% prevalence of PSE over a median follow-up period of 6.5  years. Besides larger infarct size, presence of cerebral microbleeds on brain MRI predicted PSE occurrence.
Source: Journal of Neurology - September 2, 2023 Category: Neurology Source Type: research

Left ventricular hypertrophy and left atrial size are associated with ischemic strokes among non-vitamin K antagonist oral anticoagulant users
ConclusionsPrior cerebrovascular events, diabetes, left ventricular hypertrophy, and increased left atrial size are risk factors for developing an IS among NOAC users.
Source: Journal of Neurology - August 7, 2023 Category: Neurology Source Type: research

The cysteine-altering p.R544C variant in the NOTCH3 gene is a probable candidate for blood pressure and relevant traits in the Taiwan Biobank
ConclusionNOTCH3 is a strong candidate for a role in stroke, dementia, and CADASIL, which has previously been linked to blood pressure changes. While our preliminary study suggests thatNOTCH3 p.R544C may influence blood pressure, stroke, and dementia in the Taiwan Biobank, replication in a well-powered external sample is required. This study also underlines considerable prospects of detecting novel genetic biomarkers in underrepresented worldwide populations.
Source: Journal of Neurology - August 1, 2023 Category: Neurology Source Type: research

Safety and efficacy of intravenous thrombolysis in patients with acute ischemic stroke taking direct oral anticoagulants prior to stroke: a meta-analysis
ConclusionThe meta-analysis indicated that taking DOACs prior to stroke does not significantly increase the risk of sICH in selected patients with AIS treated with IVT. Furthermore, the benefits of IVT in selected patients taking DOACs appear to be comparable to those not taking anticoagulants. Further research is warranted to confirm the findings.
Source: Journal of Neurology - June 14, 2023 Category: Neurology Source Type: research

Adult-onset leukodystrophy with vanishing white matter: a case series of 19 patients
ConclusionsAO-LVWM presents varying clinical manifestations at onset, including stroke-like events. WM rarefaction is the most consistent diagnostic clue even in the latest onset cases. Spectroscopy and electrophysiological features are compatible with axon, rather than myelin, damage. Cerebral glucose metabolic abnormalities and retinal alterations can be present. LVWM might also be caused by a digenic inheritance affecting the eIF2B complex.
Source: Journal of Neurology - May 12, 2023 Category: Neurology Source Type: research

Impacts of exposure to ambient temperature and altitude on the burden of stroke
ConclusionOverall, our study provides important insights into the environmental and individual factors that contribute to the burden of stroke in China, and may inform public health interventions aimed at reducing this burden.
Source: Journal of Neurology - May 11, 2023 Category: Neurology Source Type: research

Prediction of underlying atrial fibrillation in patients with a cryptogenic stroke: results from the NOR-FIB Study
ConclusionClinical risk scores may guide a personalized evaluation approach in CS patients. Increasing awareness of the usage of available AF-predicting scores may optimize the arrhythmia detection pathway in stroke units.
Source: Journal of Neurology - May 10, 2023 Category: Neurology Source Type: research

Dynamic changes of the direction and angle of radiographic ocular lateral deviation in patients with lateropulsion after stroke onset
ConclusionSerial changes in rOLD findings after stroke onset are different according to the responsible lesion. The direction of rOLD in most patients is in accordance with vertical perception after the acute stage of stroke.
Source: Journal of Neurology - May 9, 2023 Category: Neurology Source Type: research

Self-reported life-space mobility in the first year after ischemic stroke: longitudinal findings from the MOBITEC-Stroke project
ConclusionRoutinely assessing LSA starting value, pre-stroke mobility limitation, and FES-I may help clinicians identify patients at increased risk of failure to improve LSA.
Source: Journal of Neurology - May 4, 2023 Category: Neurology Source Type: research

Data lake-driven analytics identify nocturnal non-dipping of heart rate as predictor of unfavorable stroke outcome at discharge
ConclusionsOur data suggest that a lack of circadian HR modulation, specifically nocturnal non-dipping, is associated with short-term unfavorable functional outcome after stroke, and that including HR into machine learning-based prediction models may lead to improved stroke outcome prediction.
Source: Journal of Neurology - April 20, 2023 Category: Neurology Source Type: research

Atrial cardiomyopathy and incident ischemic stroke risk: a systematic review and meta-analysis
ConclusionAtrial cardiomyopathy markers, including electrocardiographic markers, serum markers, LA structural and functional markers, can be used to stratify the risk of incident ischemic stroke.
Source: Journal of Neurology - April 4, 2023 Category: Neurology Source Type: research

Early blood pressure management in hemorrhagic stroke: a meta-analysis
AbstractThe aim of the present meta-analysis was to evaluate the outcomes and effects of different systolic blood pressure (SBP) lowering in patients with hemorrhagic stroke using data from randomized controlled trials. A total of 2592 records were identified for this meta-analysis. We finally included 8 studies (6119 patients; mean age 62.8  ± 13.0, 62.7% men). No evidence of heterogeneity between estimates (I2 = 0% <  50%,P = 0.26), or publication bias in the funnel plots (P = 0.065, Egger statistical test) was detected. Death or major disability rates were similar between patients with intensive ...
Source: Journal of Neurology - March 8, 2023 Category: Neurology Source Type: research

Endovascular treatment achieves better outcomes than best medical management in patients with M2 occlusion and high stroke severity: a meta-analysis
ConclusionEVT may be only beneficial for patients with M2 occlusion and high stroke severity, but not for those with NIHSS scores 0 –5.
Source: Journal of Neurology - March 2, 2023 Category: Neurology Source Type: research

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