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Brain Injury and Neurodevelopmental Outcome in Congenital Heart Disease: A Systematic Review
CONCLUSIONS: Prenatal and postnatal preoperative abnormal cerebral findings might play an important role in neurodevelopmental impairment in infants with CHD. Increased awareness of the vulnerability of the young developing brain of an infant with CHD among caregivers is essential.
Source: PEDIATRICS - June 30, 2017 Category: Pediatrics Authors: Mebius, M. J., Kooi, E. M. W., Bilardo, C. M., Bos, A. F. Tags: Fetus/Newborn Infant, Cardiology, Cardiovascular Disorders Review Article Source Type: research

Breast Milk Consumption in Preterm Neonates and Cardiac Shape in Adulthood
CONCLUSIONS: This study provides the first evidence of a beneficial association between breast milk and cardiac morphology and function in adult life in those born preterm and supports promotion of human milk for the care of preterm infants to reduce long-term cardiovascular risk.
Source: PEDIATRICS - June 30, 2016 Category: Pediatrics Authors: Lewandowski, A. J., Lamata, P., Francis, J. M., Piechnik, S. K., Ferreira, V. M., Boardman, H., Neubauer, S., Singhal, A., Leeson, P., Lucas, A. Tags: Nutrition, Breastfeeding, Cardiology Article Source Type: research

Chronic Neuromotor Disability After Complex Cardiac Surgery in Early Life
This study focuses on the presence of chronic neuromotor disabilities including cerebral palsy and motor impairments after acquired brain injury in children surviving early complex cardiac surgery, providing information on the frequency, characteristics, and predictors that may assist in prevention. (Read the full article)
Source: PEDIATRICS - October 1, 2015 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Incidence and Outcomes of Symptomatic Neonatal Arterial Ischemic Stroke
Neonatal arterial ischemic stroke is associated with later cerebral palsy and cognitive impairment. Many studies on neonatal ischemic stroke are limited by modest sample sizes, and prospective studies that include outcomes assessments are scarce. Results from this prospective, nationwide, population-based study provide information on the epidemiology, associated clinical variables, clinical manifestation, vascular distribution, and treatment of neonatal arterial ischemic stroke. The study also provides outcomes regarding motor function and cognition. (Read the full article)
Source: PEDIATRICS - May 1, 2015 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Neighborhood Poverty and Allostatic Load in African American Youth
Allostatic load (AL), a biomarker of cardiometabolic risk, predicts the onset of the chronic diseases of aging including cardiac disease, diabetes, hypertension, and stroke. Socioeconomic-related stressors, such as low family income, are associated with AL. African American youth who grow up in neighborhoods in which poverty levels increase across adolescence evince high AL. The study also highlights the benefits of emotional support in ameliorating this association. (Read the full article)
Source: PEDIATRICS - October 31, 2014 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Structural Neuroplastic Change After Constraint-Induced Movement Therapy in Children With Cerebral Palsy
Research from the present laboratory with adult stroke patients showed that structural neuroplastic changes are correlated with clinical improvements due to constraint-induced movement (CI) therapy. This pilot study evaluated whether comparable changes occur in children receiving CI therapy. Ten children (6 boys) with congenital hemiparesis (mean age: 3 years, 3 months) underwent MRI scans 3 weeks before, immediately before, and immediately after receiving 3 weeks of CI therapy. Longitudinal voxel-based morphometry was performed on MRI scans to determine gray matter change. In addition, the Pediatric Motor Activity Log-Rev...
Source: PEDIATRICS - May 1, 2013 Category: Pediatrics Authors: Sterling, C., Taub, E., Davis, D., Rickards, T., Gauthier, L. V., Griffin, A., Uswatte, G. Tags: Case Report Source Type: research

Developmental Function in Toddlers With Sickle Cell Anemia
This study adds the observation that poorer neurocognitive and behavioral function is associated with older age in infants and toddlers with sickle cell anemia, much earlier than previously expected. (Read the full article)
Source: PEDIATRICS - February 1, 2013 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research