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Repetitive Transcranial Magnetic Stimulation Combined with Cognitive Training for Cognitive Function and Activities of Daily Living in Patients with Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis
CONCLUSIONS: The pooled data showed more positive effects of rTMS + cognitive training for global cognition, executive function, working memory and ADL in patients with PSCI. While, robust evidence of rTMS + cognitive training for global cognition, executive function, working memory and ADL from the Grade recommendations is lacking. Further, rTMS + cognitive training did not show no better effects on memory. Future definitive trials are needed to determine the benefits of rTMS + cognitive training for cognitive function and ADL in the field of PSCI.PMID:37004840 | DOI:10.1016/j.arr.2023.101919
Source: Ageing Research Reviews - April 2, 2023 Category: Genetics & Stem Cells Authors: Yong Gao Yue Qiu Qingyan Yang Shaowen Tang Jianqiu Gong Hong Fan Yuefeng Wu Xiao Lu Source Type: research

A Novel Deep Neural Network Model for Multi-Label Chronic Disease Prediction
Conclusions concludes this work along with future work. Dataset and Data Preprocessing In the work, we mainly focus on multiple chronic disease classification. It can be formulated into a multi-label classification problem. There are three common chronic diseases are selected from the physical examination records: hypertension (H), diabetes (D), and fatty liver (FL). In the experiments, the physical examination datasets are collected from a local medical center, which contain 110,300 physical examination records from about 80,000 anonymous patients (Li et al., 2017a,b). Sixty-two feature items are selected from over 100...
Source: Frontiers in Genetics - April 23, 2019 Category: Genetics & Stem Cells Source Type: research

The Promoter Regions of Intellectual Disability-Associated Genes Are Uniquely Enriched in LTR Sequences of the MER41 Primate-Specific Endogenous Retrovirus: An Evolutionary Connection Between Immunity and Cognition
Discussion We have found that, in the human genome, the promoter regions of ID-associated genes are uniquely enriched in MER41 LTRs. More specifically, nine ID-associated genes that are putatively important in cognitive evolution exhibit MER41 LTRs in their promoter regions. As more than 100 families of HERV are integrated into our genome, it was important to determine whether our findings are specific to MER41 and to ID-associated genes, and if so to what extent. Among the 133 families of HERV explored here, MER41 is the only family whose LTRs were found with statistically high frequency in the promoter regions of ID-ass...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

Ensemble-AHTPpred: A Robust Ensemble Machine Learning Model Integrated With a New Composite Feature for Identifying Antihypertensive Peptides
Hypertension or elevated blood pressure is a serious medical condition that significantly increases the risks of cardiovascular disease, heart disease, diabetes, stroke, kidney disease, and other health problems, that affect people worldwide. Thus, hypertension is one of the major global causes of premature death. Regarding the prevention and treatment of hypertension with no or few side effects, antihypertensive peptides (AHTPs) obtained from natural sources might be useful as nutraceuticals. Therefore, the search for alternative/novel AHTPs in food or natural sources has received much attention, as AHTPs may be functiona...
Source: Frontiers in Genetics - April 28, 2022 Category: Genetics & Stem Cells Source Type: research

The Impact of Aerobic and Resistance Training Intensity on Markers of Neuroplasticity In Health and Disease
CONCLUSION: Exercise intensity is an important variable to dose and individualize the exercise stimulus for healthy young individuals but not necessarily for healthy older adults and neurological patients. This conclusion warrants caution because studies are needed that directly compare the effects of low- vs. high-intensity exercise on neuroplasticity to determine if such changes are mechanistically and incrementally linked to improved cognition and motor function.PMID:35853549 | DOI:10.1016/j.arr.2022.101698
Source: Ageing Research Reviews - July 19, 2022 Category: Genetics & Stem Cells Authors: Tibor Hortob ágyi Tomas Vetrovsky Guilherme Moraes Balbim N árlon Cássio Boa Sorte Silva Andrea Manca Franca Deriu Mia Kolmos Christina Kruuse Teresa Liu-Ambrose Zsolt Rad ák M árk Váczi Hanna Johansson Paulo Cezar Rocha Dos Santos Erika Franz én U Source Type: research

The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease
CONCLUSION: Exercise intensity is an important variable to dose and individualize the exercise stimulus for healthy young individuals but not necessarily for healthy older adults and neurological patients. This conclusion warrants caution because studies are needed that directly compare the effects of low- vs. high-intensity exercise on neuroplasticity to determine if such changes are mechanistically and incrementally linked to improved cognition and motor function.PMID:35853549 | DOI:10.1016/j.arr.2022.101698
Source: Ageing Research Reviews - July 19, 2022 Category: Genetics & Stem Cells Authors: Tibor Hortob ágyi Tomas Vetrovsky Guilherme Moraes Balbim N árlon Cássio Boa Sorte Silva Andrea Manca Franca Deriu Mia Kolmos Christina Kruuse Teresa Liu-Ambrose Zsolt Rad ák M árk Váczi Hanna Johansson Paulo Cezar Rocha Dos Santos Erika Franz én U Source Type: research