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Source: Brain Research
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Total 24 results found since Jan 2013.

Different training patterns at recovery stage improve cognitive function in ischemic stroke rats through regulation of the axonal growth inhibitor pathway
This study investigated the effects of SRT and RWE, at the recovery stage, on the cognitive function of transient middle cerebral artery occlusion (tMCAO) rats and explored their association with NgR1/Rho-A/ROCK/LOTUS/LGI1 signaling. Adult Sprague-Dawley rats (n = 55) were divided into four groups after pretraining: SRT, RWE, tMCAO, and Sham. Rats were subjected to modified neurological severity score (mNSS) measurements and forelimb grip strength and the Morris water maze tests. Using immunofluorescence and western blotting, we evaluated axonal growth inhibitor expression in the peri-infarct cortex on days 28 and 56 after...
Source: Brain Research - December 31, 2021 Category: Neurology Authors: Chao Li Ruifang Sun Jiemei Chen Jiena Hong Ju Sun Yan Zeng Xue Zhang Zulin Dou Hongmei Wen Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

Different combinations of high-frequency rTMS and cognitive training improve the cognitive function of cerebral ischemic rats
This study aimed to evaluate the effect of different combinations of rTMS and cognitive training (rTMS-COG) on PSCI and identify the optimal combination protocol. A cerebral infarction rat model was established by transient middle cerebral artery occlusion (tMCAO). The Morris water maze test was conducted to assess the cognitive function of rats. RNA sequencing and bioinformatics analysis were employed to study the underlying mechanisms. rTMS, COG and rTMS-COG all had beneficial effects on PSCI, while cognitive training immediately after rTMS (rTMS-COG0h) achieved a better effect than cognitive training 1 h and 4 h after r...
Source: Brain Research - July 19, 2021 Category: Neurology Authors: Jiena Hong Jiemei Chen Yan Zeng Xue Zhang Mengshu Xie Chao Li Hongmei Wen Source Type: research

Vagus Nerve Stimulation Promotes Cortical Reorganization and Reduces Task-Dependent Calorie Intake in Male and Female Rats.
Abstract Numerous preclinical studies demonstrate that vagus nerve stimulation (VNS) paired with motor rehabilitation improves functional recovery after neural injuries such as stroke, traumatic brain injury, and spinal cord injury, in part by driving neural plasticity within the motor cortex. To date, these studies have been performed almost exclusively in female rats, however, the risk for neural injuries of all types is significantly higher among males than females. We therefore sought to determine whether VNS was equally effective at driving motor cortical plasticity in both sexes. Male and female rats were tr...
Source: Brain Research - September 3, 2020 Category: Neurology Authors: Tseng CT, Brougher J, Gaulding SJ, Hassan BS, Thorn CA Tags: Brain Res Source Type: research

Effects of monoaminergic drugs on training-induced motor cortex plasticity in older adults.
Abstract Primary motor cortex (M1) plasticity is involved in motor learning and stroke motor recovery, and enhanced by increasing monoaminergic transmission. Age impacts these processes but there is a paucity of systematic studies on the effects of monoaminergic drugs in older adults. Here, in ten older adults (age 61+ 4 years, 4 males), we determine the effects of a single oral dose of carbidopa/levodopa (DOPA), d-amphetamine (AMPH), methylphenidate (MEPH) and placebo (PLAC) on M1 excitability and motor training-induced M1 plasticity. M1 plasticity is defined as training related long lasting changes in M1 excitab...
Source: Brain Research - June 17, 2017 Category: Neurology Authors: Kesar TM, Belagaje SR, Pergami P, Haut MW, Hobbs G, Buetefisch CM Tags: Brain Res Source Type: research

Role of caveolin-1/vascular endothelial growth factor pathway in basic fibroblast growth factor-induced angiogenesis and neurogenesis after treadmill training following focal cerebral ischemia in rats.
Abstract Exercise is known to aid functional recovery following ischemia, though the mechanisms responsible for the beneficial effects of exercise on recovery from ischemic stroke are not fully understood. Basic fibroblast growth factor (bFGF) contributes to angiogenesis and promotes neurologic functional recovery after stroke. The present study aimed to investigate the possible mechanisms whereby treadmill exercise ameliorated impaired angiogenesis and neurogenesis following transient cerebral ischemia in middle cerebral artery occlusion (MCAO) rats. Treadmill exercise was started 2 days after ischemia-reperfusio...
Source: Brain Research - March 10, 2017 Category: Neurology Authors: Pang Q, Zhang H, Chen Z, Wu Y, Bai Liu MY, Zhao Y, Tu F, Liu C, Chen X Tags: Brain Res Source Type: research

Brain Stimulation: Neuromodulation as a Potential Treatment for Motor Recovery Following Traumatic Brain Injury.
Abstract There is growing evidence that electrical and magnetic brain stimulation can improve motor function and motor learning following brain damage. Rodent and primate studies have strongly demonstrated that combining cortical stimulation (CS) with skilled motor rehabilitative training enhances functional motor recovery following stroke. Brain stimulation following traumatic brain injury (TBI) is less well studied, but early pre-clinical and human pilot studies suggest that it is a promising treatment for TBI-induced motor impairments as well. This review will first discuss the evidence supporting brain stimula...
Source: Brain Research - February 5, 2016 Category: Neurology Authors: Clayton E, Kinley-Cooper SK, Weber RA, Adkins DL Tags: Brain Res Source Type: research

Force frequency structure below 1Hz in chronic stroke:Paretic Arm Control.
This study investigated force variability and frequency structure below 1Hz to determine whether coupled bilateral training and neuromuscular stimulation facilitated force control in paretic arms. Fifteen chronic stroke participants received nine hours of coupled bilateral movement training. Unilateral and bilateral force control tasks were administered before and after rehabilitation. Repeated measures ANOVAs were performed on the: (a) coefficient of variation and (b) absolute and relative power below 1Hz in the paretic hand. Further, a multiple linear regression analysis determined the relationship between the coefficien...
Source: Brain Research - May 3, 2014 Category: Neurology Authors: Kang N, Cauraugh JH Tags: Brain Res Source Type: research