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Source: Brain Research
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Total 24 results found since Jan 2013.

Effect of High-Frequency rTMS Combined with Bilateral Arm Training on Brain Functional Network in Patients with Chronic Stroke: An fNIRS study
CONCLUSIONS: These results suggest that the rTMS-BAT paradigm had additional effects on task-dependent brain functional reorganization. The engagement of the ipsilesional motor area in the functional network was associated with the motor impairment severity of stroke patients. fNIRS-based assessments may provide information about the neural mechanisms underlying combination interventions for stroke rehabilitation.PMID:37011721 | DOI:10.1016/j.brainres.2023.148357
Source: Brain Research - April 3, 2023 Category: Neurology Authors: Congcong Huo Gongcheng Xu Hui Xie Haihong Zhao Xuemin Zhang Wenhao Li Simin Zhang Jianfei Huo Huiyuan Li Aiping Sun Zengyong Li Source Type: research

Cortical mapping of active and passive upper limb training in stroke patients and healthy people: A functional near-infrared spectroscopy study
Brain Res. 2022 Apr 29:147935. doi: 10.1016/j.brainres.2022.147935. Online ahead of print.ABSTRACTActive exercise for upper limb training has been widely used to improve hemiplegic upper limb function, and its effect may be boosted by extrinsic visual feedback. The passive movement of the hemiplegic upper limb is also commonly used. We conducted a functional near-infrared spectroscopy experiment to compare cortical activation during the following three conditions: active left upper limb movement (on the hemiplegic sides in stroke patients), with or without extrinsic motor performance visual feedback (LAV, LAnV), and passiv...
Source: Brain Research - May 2, 2022 Category: Neurology Authors: Weili Xia Rongxia Dai Xiaojin Xu Baoyu Huai Zhongfei Bai Jiaqi Zhang Minxia Jin Wenxin Niu Source Type: research

Effectiveness and Electrophysiological Mechanisms of Focal Vibration on Upper Limb Motor Dysfunction in Patients with Subacute Stroke: A Randomized Controlled Trial
This study showed that FV was effective in improving upper limb motor function in subacute stroke patients. The underlying mechanism of FV may be that it enhances the efficacy of sensory pathways and induces plastic changes in the sensorimotor cortex.PMID:36990135 | DOI:10.1016/j.brainres.2023.148353
Source: Brain Research - March 29, 2023 Category: Neurology Authors: Lian Wang Saihua Wang Song Zhang Zulin Dou Tiecheng Guo Source Type: research

Variation of body  weight supported treadmill training parameters during a single session can modulate muscle activity patterns in post-stroke gait
Exp Brain Res. 2023 Jan 13. doi: 10.1007/s00221-023-06551-7. Online ahead of print.ABSTRACTEvidence supporting the benefits of locomotor training (LT) to improve walking ability following stroke are inconclusive and could likely be improved with a better understanding of the effects of individual parameters i.e., body weight support (BWS), speed, and therapist assistance and their interactions with walking ability and specific impairments. We evaluated changes in muscle activity of thirty-seven individuals with chronic stroke (> 6 months), in response to a single session of LT at their self-selected or fastest-comfortab...
Source: Brain Research - January 13, 2023 Category: Neurology Authors: Shraddha Srivastava Bryant A Seamon Carolynn Patten Steven A Kautz Source Type: research

Force frequency structure below 1Hz in chronic stroke:Paretic Arm Control.
This study investigated force variability and frequency structure below 1Hz to determine whether coupled bilateral training and neuromuscular stimulation facilitated force control in paretic arms. Fifteen chronic stroke participants received nine hours of coupled bilateral movement training. Unilateral and bilateral force control tasks were administered before and after rehabilitation. Repeated measures ANOVAs were performed on the: (a) coefficient of variation and (b) absolute and relative power below 1Hz in the paretic hand. Further, a multiple linear regression analysis determined the relationship between the coefficien...
Source: Brain Research - May 3, 2014 Category: Neurology Authors: Kang N, Cauraugh JH Tags: Brain Res Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

Role of caveolin-1/vascular endothelial growth factor pathway in basic fibroblast growth factor-induced angiogenesis and neurogenesis after treadmill training following focal cerebral ischemia in rats.
Abstract Exercise is known to aid functional recovery following ischemia, though the mechanisms responsible for the beneficial effects of exercise on recovery from ischemic stroke are not fully understood. Basic fibroblast growth factor (bFGF) contributes to angiogenesis and promotes neurologic functional recovery after stroke. The present study aimed to investigate the possible mechanisms whereby treadmill exercise ameliorated impaired angiogenesis and neurogenesis following transient cerebral ischemia in middle cerebral artery occlusion (MCAO) rats. Treadmill exercise was started 2 days after ischemia-reperfusio...
Source: Brain Research - March 10, 2017 Category: Neurology Authors: Pang Q, Zhang H, Chen Z, Wu Y, Bai Liu MY, Zhao Y, Tu F, Liu C, Chen X Tags: Brain Res Source Type: research

Brain Stimulation: Neuromodulation as a Potential Treatment for Motor Recovery Following Traumatic Brain Injury.
Abstract There is growing evidence that electrical and magnetic brain stimulation can improve motor function and motor learning following brain damage. Rodent and primate studies have strongly demonstrated that combining cortical stimulation (CS) with skilled motor rehabilitative training enhances functional motor recovery following stroke. Brain stimulation following traumatic brain injury (TBI) is less well studied, but early pre-clinical and human pilot studies suggest that it is a promising treatment for TBI-induced motor impairments as well. This review will first discuss the evidence supporting brain stimula...
Source: Brain Research - February 5, 2016 Category: Neurology Authors: Clayton E, Kinley-Cooper SK, Weber RA, Adkins DL Tags: Brain Res Source Type: research

Treadmill exercise decreases cerebral edema in rats with local cerebral infarction by modulating AQP4 polar expression through the caveolin-1/TRPV4 signaling pathway
This study investigated the influence of treadmill exercise on brain edema and the mechanism of its formation and elimination. The MCAO model was established with Sprague-Dawley (SD) rats, and lentivirus-mediated caveolin-1 shRNA was used to investigate the role of caveolin-1 in brain edema. As expected, we found that treadmill exercise has a beneficial effect on brain edema after stroke. Training led to a significant increase in the expression of caveolin-1 and TRPV4; and reduced brain water content and blood-brain barrier (BBB) damage. This treatment also changed the localization of aquaporin-4 (AQP4). Moreover, the effe...
Source: Brain Research - August 12, 2022 Category: Neurology Authors: Anqi Zhu Yao Lin Xuanbo Hu Zaizai Lin Yongqiang Lin Qingfeng Xie Shaobo Ni Hui Cheng Qiaoya Lu Shanshan Lai Guoyuan Pan Xiang Chen Wei Pang Chan Liu Source Type: research

Neuroprotective Effects of Pre-Ischemic Exercise are linked to Expression of NT-3/NT-4 and TrkB/TrkC in Rats
CONCLUSION: The findings showed that pre-ischemic exercise can exert neuroprotective effectsvia NT-3 and NT-4 pathways against ischemia in hippocampal CA1 neurons and promote post-injury sensorimotor recovery.PMID:36646145 | DOI:10.1016/j.brainresbull.2023.01.004
Source: Brain Research - January 16, 2023 Category: Neurology Authors: AbdorrezaEghbal Moghanlou Mohtaram Yazdanian Sajad Roshani Abdullah Demirli Mehdi Seydyousefi Gerlinde A S Metz Zeinab Faghfoori Source Type: research