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Source: Molecules
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Molecules, Vol. 28, Pages 761: A Simple Synthesis of Reduction-Responsive Acrylamide-Type Nanogels for miRNA Delivery
In this study, acrylamide-based nanogels containing cationic groups and redox-sensitive crosslinkers were developed for cellular delivery of anti-miR21 (a-miR21). To achieve this, post-polymerization loading of a-miR21 oligonucleotides into nanogels was performed by utilizing the electrostatic interaction between positively charged nanogels and negatively charged oligonucleotides. Different molar ratios of the amine groups (N) on the cationic nanogel and phosphate groups (P) on the miRNA were investigated. An N/P ratio of 2 allowed high miRNA loading capacity (MLC, 6.7% w/w) and miRNA loading efficiency (MLE, 99.7% w/w). S...
Source: Molecules - January 12, 2023 Category: Chemistry Authors: Ali Maruf Ma łgorzata Milewska Anna Lalik Sebastian Student Ilona Wandzik Tags: Article Source Type: research
