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Cardiovascular comorbidities in atopic dermatitis: Potential implications for the use of Janus kinase inhibitors
To the Editor: The Food and Drug Administration recently approved the use of 2 oral Janus kinase (JAK) inhibitors —abrocitinib and upadacitinib—for patients with moderate-to-severe atopic dermatitis (AD) not adequately controlled with systemic therapies, including biologics, or when the use of such treatments is inadvisable.1,2 In September 2021, the Food and Drug Administration issued a boxed warning for a ll JAK inhibitors regarding the increased risk of serious infections, heart attack, stroke, cancer, blood clots, and death.
Source: Journal of the American Academy of Dermatology - August 19, 2023 Category: Dermatology Authors: J. Mark Jackson, Amanda Althoff, Lawrence Rasouliyan, Stacey Long, Carla L. Zema Tags: Research letter Source Type: research

28464 Hidradenitis suppurativa and association with stroke: Systematic review and meta-analysis
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by painful nodules, abscesses, sinus tract formation, and scarring. HS has a number of associations with systemic disorders, including cardiovascular disease and metabolic syndrome. However, the relationship between HS and strokes is not well established. To assess this potential association, a systematic review and meta-analysis was performed.
Source: Journal of the American Academy of Dermatology - August 8, 2021 Category: Dermatology Authors: Kevin Phan, William Ng, Belinda Lai, Amit Garg, Saxon D. Smith Source Type: research

28675 A case of systemic amyloidosis diagnosed by dermatologic consult
A 49-year-old male with PMH of hypertension and diabetes was admitted to the neurology ICU following thrombolytic therapy for left MCA occlusive thrombus. Dermatology was consulted for desquamation of the lower lip, lateral tongue, and bruising of the eyelid and cheeks. Patient originally presented to outside hospital with bilateral lower extremity swelling and shortness of breath. BNP and troponins were elevated, and ACS protocol was initiated. He had stroke-like symptoms while at the outside facility and CT showed MCA occlusive thrombus.
Source: Journal of the American Academy of Dermatology - August 8, 2021 Category: Dermatology Authors: Alison Huber, Dr. Emily Smith Source Type: research

The dream of a good night's sleep for our dermatology patients
Are you getting adequate sleep? Chances are that you are not and the repercussions could be profound. Sleep deprivation has been associated with insulin resistance, diabetes mellitus, obesity, hypertension, obstructive sleep apnea, anxiety and depression, and an increased risk of myocardial infarction and stroke. Quality of life (QoL) may suffer by poor job performance, an increased risk of accidents, and family stress.1
Source: Journal of the American Academy of Dermatology - August 2, 2021 Category: Dermatology Authors: Warren R. Heymann Tags: A clinician's perspective Source Type: research

Health-related quality of life and economic burden of prurigo nodularis
Capsule Summary • Prurigo nodularis is a chronic inflammatory skin disease associated with significant quality of life impairment, similar to the level of other debilitating chronic conditions, such as stroke and heart failure.• Early and aggressive symptomatic treatment of PN is warranted to improve patient qu ality of life.
Source: Journal of the American Academy of Dermatology - May 27, 2021 Category: Dermatology Authors: Katherine A. Whang, Thomas K. Le, Raveena Khanna, Kyle A. Williams, Youkyung Sophie Roh, Nishadh Sutaria, Justin Choi, Sylvie Gabriel, Rajeev Chavda, Yevgeniy Semenov, Shawn G. Kwatra Source Type: research

18756 Skin biopsy for the diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: A report of two cases
Skin biopsy has become a useful tool for the diagnosis of extracutaneous diseases as a relatively benign procedure with a good performance. The evaluation of dermal and epidermal innervation and vasculature show distinct changes that support the diagnosis of specific neurologic diseases. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited angiopathy caused by mutations in the NOTCH3 gene on chromosome 19. It is characterized by stroke and vascular cognitive impairment in the young and other neurological manifestations.
Source: Journal of the American Academy of Dermatology - November 28, 2020 Category: Dermatology Authors: Maria Pereira, Khanty Loyola, Gonzalo Hevia, Ximena Fajre, Diego Rocha, Pablo Brinck, Marcela Schultz Source Type: research

16834 Risk of hemorrhagic and ischemic stroke subsequent to diagnosis for hidradenitis suppurativa: Real-world data from a large urban Midwestern US patient population
Background: Although hidradenitis suppurativa (HS) has been reported to be associated with cardiovascular events, the risk for stroke has been inconsistently reported. The aim of this study is to determine the incidence of stroke in HS patients from real world data within a large urban midwestern US dermatology patient population.
Source: Journal of the American Academy of Dermatology - November 28, 2020 Category: Dermatology Authors: Jennifer Parker, Eran Gwillim, Yasmeen Ali, David Randall Pease, Anne E. Laumann, Dennis P. West, Beatrice Nardone Source Type: research

Comment on “Patient preference for cellulitis treatment: At-home care is preferred to hospital-based treatment”
To the Editor: We  read with interest the recent survey study from Gabel et al1 highlighting the preference of patients for at-home treatment of cellulitis rather than hospital-based care. Notably, these results reflected patient preferences well before the onset of the COVID-19 pandemic. In light of recent reports linking patient anxiety over COVID-19 to delayed and decreased hospital presentations for acute medical problems such as myocardial infarction2 and stroke,3 we examined whether a similar trend was observed for patients presenting with skin and soft tissue infections (SSTIs) at an urban tertiary car e center at...
Source: Journal of the American Academy of Dermatology - August 7, 2020 Category: Dermatology Authors: Katharina S. Shaw, Theodora K. Karagounis, Lu Yin, Grace Gibbon, Rebecca A. Betensky, Kristen I. Lo Sicco, Alisa N. Femia Tags: JAAD Online Source Type: research

The risk of myocardial infarction, stroke and revascularization among patients with psoriasis treated with apremilast compared to biologics and DMARDs: a cohort study in the United States MarketScan database
Source: Journal of the American Academy of Dermatology - March 24, 2020 Category: Dermatology Authors: Rebecca Persson, Katrina Wilcox Hagberg, Ellen (Yiran) Qian, Catherine Vasilakis-Scaramozza, Susan Jick Source Type: research

The risk of myocardial infarction, stroke, and revascularization among patients with psoriasis treated with apremilast compared with biologics and disease-modifying antirheumatic drugs: A cohort study in the US MarketScan database
To the Editor: The cardiovascular safety of apremilast is understudied.1,2 We conducted a study to quantify the risk of myocardial infarction, stroke, and revascularizations in people with apremilast-treated psoriasis compared with other systemic psoriasis treatments.
Source: Journal of the American Academy of Dermatology - March 24, 2020 Category: Dermatology Authors: Rebecca Persson, Katrina Wilcox Hagberg, Yiran Qian, Catherine Vasilakis-Scaramozza, Susan Jick Tags: Letter Source Type: research

In memoriam: Haines Ely, MD, FAAD
Aside from the news about the canceling of the American Academy of Dermatology Annual Meeting in Denver, there is horrible news that is difficult with every key stroke as I write today …Dr Haines Ely, long-standing pinnacle member of Noah Worcester, Pacific Dermatologic Association, RxDerm, and the American Academy of Dermatology, has passed away after a long battle with prostate cancer. He is survived by his wife, Jenny, and adult daughters, Meredith Bordoni (Michael), Rebecca Ely, and Tess Ely.
Source: Journal of the American Academy of Dermatology - March 12, 2020 Category: Dermatology Authors: Neal Bhatia Tags: In memoriam Source Type: research

9824 —Prevention of taxane-induced alopecia and nail toxicity
Introduction: Hidradenitis suppurativa (HS) and psoriasis have been linked to cardiovascular disease. There is currently a deficiency in the literature regarding the prevalence of clinically important cardiovascular diseases that arise in patients with HS in a United States population. We sought to determine the odds of stroke, coronary artery disease (CAD), heart failure (HF), and peripheral artery disease (PAD) in patients with HS compared with patients with psoriasis and controls.
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

9798 —Hidradenitis suppurativa is associated with increased odds of stroke, coronary artery disease, heart failure, and PAD: A population-based analysis in the United States
Introduction: Hidradenitis suppurativa (HS) and psoriasis has been linked to cardiovascular disease. There is currently a deficiency in the literature regarding the prevalence of clinically important cardiovascular diseases that arise in patients with HS in a United States population. We sought to determine the odds of stroke, coronary artery disease (CAD), heart failure (HF), and peripheral artery disease (PAD) in patients with HS compared with patients with psoriasis and controls.
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: A case of a neurologic disease with a skin-deep diagnosis
We present a 34-year-old woman with history of recurrent migraine headaches and right pontine stroke who presented to our emergency department for intermittent blurry vision and worsening headache.
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

The bacteria stroke: Leclercia adecarboxylata folliculitis in a healthy swimmer —an emerging aquatic pathogen?
A 12-year-old healthy boy presented with a 2-month painful acneiform eruption. On exam erythematous follicular papules and pustules were scattered over bilateral shoulders and back. These surfaces were moderately tender to light palpation; the patient even complained that clothing in contact with his skin elicited pain. Doxycycline 75 mg po qd × 10 days was prescribed to cover common Staphylococcus aureus folliculitis. Due to the atypical presentation of significant pain, a bacterial culture was collected.
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

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