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O-032 Treatment outcomes for ARUBA eligible brain arteriovenous malformations: a comparison of real world data from the NVQI-QOD AVM registry to the ARUBA trial
ConclusionARUBA eligible patients from the NVQI-QOD registry demonstrate a significantly lower risk of stroke or death with intervention of 8.0% (N=174) compared to the 30.7% (N=114) ARUBA trial interventional risk, and is nearly equivalent to the ARUBA trial medical management risk of 10.1% (N=109) over 33 months.Disclosures N. Moore: 1; C; SNIS Joe Niekro Research Grant. R. Abdalla: None. T. Patterson: None. Y. Moazeni: None. P. Rasmussen: 2; C; Blockade Medical, Covidien/Medtronic, Stryker Neurovascular, Perflow Medical. 4; C; Perflow Medical. G. Toth: None. M. Bain: 2; C; Stryker Neurovascular. S. Ansari: None. S. Huss...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Moore, N., Abdalla, R., Patterson, T., Moazeni, Y., Rasmussen, P., Toth, G., Bain, M., Ansari, S., Hussain, S. Tags: Oral abstracts Source Type: research

O20 Thrombectomy for medium vessel occlusions: treatment effect of successful recanalization on long term functional outcome
ConclusionTICI 2b recanalization in MeVO increased probability of good outcome from 27% to 58%, TICI 3 recanalization did not further improve prognosis. Do you have any conflict of interest to declare?: YesConflict of Interest StatementHelge Kniep and Fabian Flottmann are consultants for Eppdata.Milani Deb-Chatterji has received research grants from the Werner Otto Stiftung.Götz Thomalla received fees as consultant from Acandis, Bayer, and Portola, and fees as lecturer from Acandis, Alexion, Amarin, Bayer, Boehringer-Ingelheim, BristolMyersSquibb, Daiichii Sankyo, Portola, and Stryker.Jens Fiehler received research...
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: Kniep, H., Bechstein, M., Broocks, G., Brekenfeld, C., Flottmann, F., Deb-Chatterji, M., Meyer, L., Hanning, U., Thomalla, G., Fiehler, J., Gellissen, S. Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

P46 How much of the improvement in functional outcome after successful recanalization is explained by follow-up infarct volume reduction?
Conclusions57% of the improvement of functional outcome after successful recanalization is explained by follow-up infarct volume reduction. Results reflect established pathophysiological assumptions and confirm the value of infarct volume as imaging endpoint in clinical trials.ReferencesBoers AMM, Jansen IGH, Brown S, et al. Mediation of the relationship between endovascular therapy and functional outcome by follow-up infarct volume in patients with acute ischemic stroke. Jama Neurology 2019;76:194–202. DOI: 10.1001/Jamaneurol.2018.3661 Do you have any conflict of interest to declare?: YesConflict of Interest Stateme...
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: Kniep, H., Meyer, L., Bechstein, M., Broocks, G., Austein, F., Brekenfeld, C., Flottmann, F., Deb-Chatterji, M., Thomalla, G., Hanning, U., Fiehler, J., Gellissen, S. Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

EP44* Nimbus geometric clot extractor for tough clots - Real world clinical experience and clot composition
ConclusionsNimbus is effective in removing tough clots markedly rich in fibrin and platelets in challenging real world situations.ReferenceJens Fiehler. Failed thrombectomy in acute ischemic stroke: return of the stent? Stroke 2018;49:811–812. https://doi.org/10.1161/STROKEAHA.118.020541DisclosureThis series has emanated from research supported in part by a grant from Science Foundation Ireland (SFI) and the European Regional Development Fund (ERDF) under grant number 13/RC/2073_P2. It is the independent clinical practice of the authors. Cerenovus provided support for post hoc data collection and analysis.
Source: Journal of NeuroInterventional Surgery - August 24, 2021 Category: Neurosurgery Authors: Nordmeyer, H., Doyle, K., Gralla, J., Phung, T., Molina Gil, S., Belachew, N., Neuhaus, S., Douglas, A., Mordasini, P. Tags: Treatment Source Type: research

E-027 Matricidal cavernous aneurysms: a multicenter case series
Conclusion Matricidal aneurysms require careful consideration and planning. The restricted anatomy of the cavernous sinus can make successful execution of endovascular interventions difficult. Direct elastic compression of the parent artery does not respond to angioplasty and stenting the way that atherosclerotic stenosis does. Because of this, planning for possible parent vessel sacrifice is important. Abstract E-027 Table 1 Intended Treatments and Outcomes n Intended Treatment Failed Treatment (rate) All Patients 37 10 (27%) Flow Diversion 18 5 (28%) Parent Vessel Sacrifice 11 With Bypass 4 2 (50%) Without Bypass 7 0 ...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Roberts, M., Nickele, C., Welch, B., Ban, V., Ringer, A., Kim, L., Levitt, M., Lanzino, G., Kan, P., Shallwani, H., Siddiqui, A., Elijovich, L., Arthur, A. Tags: Electronic Poster Abstracts Source Type: research

O-007 First US multicenter experience using the pipeline flex embolization device with shield technology for treatment of intracranial aneurysms - periprocedural outcomes and early safety profile
ConclusionOur study is the first to report the early experience with the newly FDA-approved PED Flex with Shield technology amongst US centers. Our results are comparable with non-US, international studies showing a high technical success rate and safe peri-procedural angiographic and patient outcome. Long-term follow-up will be needed to provide more robust data on angiographic and patient outcomes.Disclosures A. Kuhn: None. J. Singh: None. A. Abdelsalam: None. V. Saini: None. J. Burks: None. G. Cortez: None. R. Abbas: None. M. Pervez: None. H. Saei: None. S. Burke: None. V. Naragum: None. F. Massari: None. S. Marwah: Non...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Kuhn, A., Singh, J., Abdelsalam, A., Saini, V., Burks, J., Cortez, G., Abbas, R., Pervez, M., Saei, H., Burke, S., Naragum, V., Massari, F., Marwah, S., Gounis, M., Hassan, A., Malek, A., Dabus, G., Linfante, I., Tjoumakaris, S., Jabbour, P., Hanel, R., S Tags: SNIS 19th annual meeting oral abstracts Source Type: research

E-044 Patient outcomes after treatment of brain aneurysm in small diameter vessels with the silk vista baby flow diverter: a systematic review
ConclusionThis systematic review suggests that SVB is a safe and effective treatment for intracranial aneurysms in small vessels. Device trackability and reduced system dimensions, also facilitated the treatment of previously judged not amenable lesions, including a wide range of aneurysms located in anterior and posterior circulation distal vessels. Further prospective and comparative studies with patient outcome data specific to aneurysm location are needed to confirm the safety and efficacy of SVB.Disclosures R. Hanel: 1; C; Unrestricted research grant from NIH, Interline Endowment, Microvention, Stryker, CNX.. 2; C; Me...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Hanel, R., Cortez, G., Benalia, V., Sheffels, E., Sutphin, D., Pederson, J., Pereira, V. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

P-007 Thrombectomy techniques alter the pathology of harvested clots
ConclusionThe pathological evaluation of the retrieved clot can be affected by the original clot type and the type of mechanical thrombectomy. These differences in changes in clot pathology need to be recognized for stroke research.Abstract P-007 Figure 1Disclosures T. Imahori: 1; C; Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research. M. Ghovvati: None. L. Guo: None. A. M Gajjar: None. S. Tateshima: 2; C; Medtronic, Stryker, Cerenovus, Rapid Medical. N. Kaneko: 2; C; Medtronic, Stryker.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Imahori, T., Ghovvati, M., Guo, L., Gajjar, A., Tateshima, S., Kaneko, N. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

Introduction
This online supplement is the first of three featuring previously accepted manuscripts focusing on ischemic stroke. The last decade has witnessed a revolution in the endovascular management of acute ischemic stroke. Device improvement, better-constructed prospective trials, and refinements in endovascular techniques have sparked this revolution. However, critical issues still need to be addressed. Specifically, the importance of pre-thrombectomy imaging, medium-sized vessel thromboses, patient access to capable treatment centers, management of intracranial atherosclerosis, and posterior circulation disease are subjects of ...
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Albuquerque, F. C. Tags: Editorial Source Type: research

E-070 the surpass intracranial aneurysm embolization system pivotal trial to treat large or giant wide neck aneurysms (scent trial)
ConclusionThe SCENT trial is currently enrolling and is expected to complete enrollment by mid-2015.DisclosuresA. Puri: 1; C; Research grant from Stryker. 2; C; Codman and Covidien. R. Hanel: 2; C; Stryker, Codman and Covidien. 4; C; Blockade. 5; C; Scientific advisory board- Medina medical. P. Meyers: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Puri, A., Hanel, R., Meyers, P. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

E-139 in vivo perfusion imaging using magnetic particle imaging
ConclusionMPI shows great promise as a sensitive, high-contrast, and radiation-free technique for measuring brain perfusion, brain vasculature, and organ perfusion.AcknowledgmentsThe authors acknowledge support from the following research grants: NIH 5R01EB013689–03, CIRM RT2–01893, Keck Foundation 034317, NIH 1R24MH106053–01, NIH 1R01EB019458–01, ACTG 037829, and NIH 2R42EB013520–02A1.ReferencesWintermark M, et al. Stroke, 2005:e83Weizenecker J, et al. PMB 2009;54(5)Rahmer J, et al. PMB 2013;58(12):3965–77Saritas E, et al. JMR 2013;229:116–26Ferguson, et alet al. IEEE-TMI, in pres...
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Goodwill, P., Ferguson, M., Yu, E., Zheng, B., Lu, K., Khandhar, A., Kemp, S., Krishnan, K., Conolly, S. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

Authors reply
We greatly appreciate the response of Mehta and colleagues to our paper. The ADAPT FAST study was an unfunded multicenter registry conducted independently by a group of committed physicians in an effort to further the understanding of stroke treatment. This was not a grant-funded prospective randomized trial. Revascularization assessments were made by the operators rather than a blinded independent core laboratory. We certainly acknowledge the limitations inherent in the design of the study. At the same time, despite these limitations, we feel that our study provides an important initial assessment of the safety and effica...
Source: Journal of NeuroInterventional Surgery - June 11, 2016 Category: Neurosurgery Authors: Turner, R., Fiorella, D., Mocco, J., Frei, D., Baxter, B., Siddiqui, A., Spiotta, A., Chaudry, I., Turk, A. S. Tags: PostScript Source Type: research

O-013 Hypertension Decreases the Number and Duration of Collateral Openings during Middle Cerebral Artery Occlusion (MCAO) and Impairs Reperfusion
ConclusionsThese results demonstrate that collateral flow during ischemia, and reperfusion, was impaired in hypertension likely due to vasoconstriction of LMAs. Understanding the function of pial collaterals under conditions such as hypertension, that is associated with little penumbral tissue, may provide targeted therapies to prevent collateral failure and extend the time window for treatment in these patients.DisclosuresM. Cipolla: 1; C; NIH grants. J. Sweet: None. K. Chan: None.
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Cipolla, M., Sweet, J., Chan, K. Tags: Oral abstracts Source Type: research

E-076 Embotrap thrombectomy and subsequent embolic events
Conclusion Based on this preliminary study, it is our conclusion that stent retriever design can be optimized to alter the particle size distribution of distal emboli. When encountering friable hard clots, the use of the EmboTrap device may provide a reduction in distal emboli to both affected and unaffected territories and should be considered. Disclosures: J. Chueh: None. M. Marosfoi: None. R. King: None. O. Brooks: None. A. Puri: None. M. Gounis: 1; C; research grant. 6; C; Travel Support.
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Chueh, J., Marosfoi, M., King, R., Brooks, O., Puri, A., Gounis, M. Tags: Electronic Poster Abstracts Source Type: research

P-026 Aqua embolic system: evaluating the performance of a new liquid embolic system using a swine AVM model
ConclusionsAES, which is a DMSO free, non-adhesive polysaccharides based LEM, may be used as an embolic material for the treatment of hemorrhagic stroke caused by cerebrovascular diseases, such as brain AVM.A: common carotid artery injection (AP view) shows left ascending pharyngeal artery (APA) and left rete mirabile (red arrow). B: AES is injected from the microcatheter. The AES reflux is reaching the tip of the microcatheter. C: With continuous injection of AES, the microcotheter tip is embedded ¡n the cost of AES. D. Post treatment angiogram shows complete occlusion of the left rete mirabile and APADisclosures I....
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Yuki, I., Ohkawa, K., Li, S., Steward, E., Nguyen, B., Hsu, F., Xu, J., Suzuki, S. Tags: Oral poster abstracts Source Type: research

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