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Source: Neurology
Education: Education

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Total 259 results found since Jan 2013.

Predictors of Change in Quality of Life in Patients With Focal Neurological Damage Following an Outpatient Cognitive Rehabilitation Program (P1.284)
CONCLUSIONS:In patients with FND following an OCR program, the analysis of independent predictors of QoL change may allow for a better prediction of treatment response.Study Supported by:Disclosure: Dr. Rojas has nothing to disclose. Dr. Leis has nothing to disclose. Dr. Ciufia has nothing to disclose. Dr. Saux has nothing to disclose. Dr. Feldberg has nothing to disclose. Dr. Caceres has received personal compensation for activities with Abbott, Serono Inc., and Teva Neuroscience as a speaker. Dr. Demey has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Rojas, G., Leis, A., Ciufia, N., Saux, G., Feldberg, C., Caceres, F., Demey, I. Tags: Neural Repair and Neuro-rehabilitation: Basic Science Source Type: research

Treating Neglect by Body Movements: A Case Report and Follow-Up Study (P3.043)
DISCUSSION: Our initial neglect patient named left-sided objects better when cued to move midline structures to the left. If midline structures are represented more bilaterally in the brain, they may be less affected by body-centered "aiming" bias. Future research would examine whether cueing with the nose/tongue is selectively helpful for patients with more severe neglect or with "aiming" bias and limb akinesia.STUDY SUPPORTED BY: National Institutes of Health and Kessler Foundation.Disclosure: Dr. Chaudhari has nothing to disclose. Dr. Pigott has nothing to disclose. Dr. Chen has nothing to disclose. Dr. Barrett has rece...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Chaudhari, A., Pigott, K., Chen, P., Barrett, A. Tags: Neural Repair and Neuro-rehabilitation: Clinical Source Type: research

Validating an Electronic Method for Prospective Fall Counting in People with MS (P3.142)
CONCLUSIONS: These data suggest that a daily electronic fall survey is a valid method for prospectively assessing fall frequency in people with MS. Further study with larger samples is needed. Support by: Michelle Cameron was supported by a CDA-2 from the Veterans Affairs Rehabilitation Research Development Service. Disclosure: Dr. Downs has nothing to disclose. Dr. Murchison has received research support from National Institute for Neurological Disorders and Stroke. Dr. Mazumder has received research support from the Agency for Healthcare Research and Quality, and the 2012 Foundation of the Consortium of MS Center...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Downs, A., Murchison, C., Mazumder, R., Cameron, M. Tags: MS and CNS Inflammatory Disease: Tools for Clinical Assessment and Therapeutic Response Source Type: research

4-Year Follow-up of Delayed-Release Dimethyl Fumarate Treatment in Relapsing-Remitting Multiple Sclerosis (RRMS): Integrated Magnetic Resonance Imaging (MRI) Outcomes From DEFINE, CONFIRM, and the ENDORSE Extension Study (P3.160)
CONCLUSIONS: Reduced frequency of new MRI lesions is maintained over 4 years among patients continuing therapy. Switching from placebo to delayed-release DMF, patients demonstrated MRI outcomes similar to those with delayed-release DMF in DEFINE/CONFIRM. Together with clinical efficacy and an acceptable safety profile, results support delayed-release DMF as a potential long-term treatment option for relapsing MS.Study Supported by: Biogen IdecDisclosure: Dr. Arnold has received personal compensation for activities with Acorda Therapeutics, Bayer Pharmaceuticals Corporation, Biogen Idec, Coronado Biosciences, EMD Serono, Ge...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Arnold, D., Fox, R., Gold, R., Havrdova, E., Kappos, L., Yousry, T., Zhang, R., Yang, M., Viglietta, V., Sheikh, S., Miller, D. Tags: MS and CNS Inflammatory Disease: Clinical Trials Outcomes Source Type: research

Improving Assessment and Documentation of Pain Management at University of Florida - Jacksonville. (P4.290)
CONCLUSIONS:Resident education, development of standardized templates for H&P and progress notes and continuous compliance monitoring have significantly improved pain documentation and treatment.Disclosure: Dr. Shapovalov has nothing to disclose. Dr. Antonios has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Shapovalov, D., Antonios, N. Tags: Practice, Policy, and Ethics: Stroke, Critical Care, and Other Source Type: research

Helping Haiti: Addressing the Burden of Neurologic Disease (P4.292)
CONCLUSIONS: With this nationwide collaborative and interdisciplinary approach, we hope to have a dramatic impact on the perceptions and outcomes of neurologic disease and provide a continuous, but dynamic presence in Port au Prince, Haiti while training physicians, nurses, and other team members in global health perspectives.Disclosure: Dr. Santini has nothing to disclose. Dr. Alessi has received personal compensation for activities with CBS Radio, the National Football League Players Association, and Colonial Cooperative Care. Dr. Jones has nothing to disclose. Dr. Etienne has nothing to disclose. Dr. Hohler has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Santini, V., Alessi, A., Jones, E., Etienne, M., Hohler, A. Tags: Global Health and Infection Source Type: research

Three Sib-Pairs of Autopsy-Confirmed Progressive Supranuclear Palsy (P5.248)
CONCLUSIONS:Affected members from all three families presented classical clinical and pathological PSP features. However, the age at onset in a sib-pair carrying a MAPT mutation was younger than typical. Future studies are warranted on our MAPT mutation negative families with the goal of identifying a novel gene for PSP associated with late-onset and typical tau pathology.Study Supported By: P50NS72187; the Family of Carl Edward Bolch, Jr. and Susan Bass Bolch; the Society for PSP and the Mayo Foundation for Research and Education and the Max Kade Foundation.Disclosure: Dr. Fujioka has nothing to disclose. Dr. Sanchez Cont...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Fujioka, S., Sanchez Contreras, M., Strongosky, A., Ogaki, K., Whaley, N., Tacik, P., Van Gerpen, J., Uitti, R., Ross, O., Wszolek, Z., Rademakers, R., Dickson, D. Tags: Movement Disorders: Atypical Parkinsonism Source Type: research

Long-term Outcomes of Parkinson's Disease Patients with Normal Cognition. (P5.260)
Conclusion:More than one-third of PD patients with NC develop cognitive impairment within 4 years, and the majority of new MCI cases convert to dementia within 3 years. Worse executive, language and memory abilities all predict future decline. These results are consistent with previous studies reporting that the overwhelming majority of PD patients develop cognitive impairment long-term, and have implications for understanding disease course and clinical care.Disclosure: Dr. Pigott has nothing to disclose. Dr. Rick has nothing to disclose. Dr. Hurtig has nothing to disclose. Dr. Chen-Plotkin has received research support f...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Pigott, K., Rick, J., Hurtig, H., Chen-Plotkin, A., Duda, J., Morley, J., Chahine, L., Dahodwala, N., Fleisher, J., Akhtar, R., Siderowf, A., Goldmann Gross, R., Xie, S., Trojanowski, J., Weintraub, D. Tags: Movement Disorders: Cognition and Parkinson ' s Disease Source Type: research

Predictors of Recovery of Chronic Aphasia (P6.228)
Conclusions: Chronic aphasia recovery is positively influenced by higher education, smaller lesions, younger age, and current antidepressant use (independently of one another).*Study supported by: NIH R01 DC05375Disclosure: Dr. Suneja has nothing to disclose. Dr. Gonzalez-Fernandez has nothing to disclose. Dr. Hillis has received research support from Allon Pharmaceutical.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Suneja, A., Gonzalez-Fernandez, M., Hillis, A. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Language Source Type: research

Oral Anticoagulant Therapy Is Associated with Cerebral Microbleeds (I2-2.001)
Conclusions: OAT relates to both prevalent and incident microbleeds. Furthermore, maximum INR values and variability in INR are risk factors for microbleeds, particularly deep or infratentorial microbleeds.Study Supported by: Erasmus Medical Center;Research Institute for Diseases in the Elderly;Ministry of Education, Health,Welfare and Sports.Disclosure: Dr. Akoudad has nothing to disclose. Dr. Darweesh has nothing to disclose. Dr. Leening has nothing to disclose. Dr. Koudstaal has nothing to disclose. Dr. Hofman has received personal compensation in an editorial capacity for the European Journal of Epidemiology. Dr. Van D...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Akoudad, S., Darweesh, S., Leening, M., Koudstaal, P., Hofman, A., Van Der Lugt, A., Stricker, B., Ikram, M., Vernooij, M. Tags: New Antithrombotic Agents for Stroke Prevention Data Blitz Presentations Source Type: research

Closing the Loop: Mount Sinai Neurology Resident Clinical Acumen Assessment Project (S30.006)
CONCLUSION:This project presents a novel educational initiative to assess and improve neurology resident clinical acumen. Diagnostic accuracy varied widely across disorders, though was similar for CNS vs. PNS cases. Accuracy was highest in CNS diagnoses with most frequent clinical exposure but can be improved across-the-board.Disclosure: Dr. Zubkov has nothing to disclose. Dr. Brandstadter has nothing to disclose. Dr. Hannigan has nothing to disclose. Dr. Krieger has received personal compensation for activities with Acorda Therapeutics, Bayer Healthcare, Biogen Idec, Genzyme Corporation, Questcor, and Teva Neuroscience. D...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Zubkov, S., Brandstadter, R., Hannigan, C., Krieger, S. Tags: Education, Research, and History Source Type: research

Cholesterol, Statins and the Risk of Dementia in the Oldest-Old: The 90+ Study (S58.003)
CONCLUSIONS: Contrary to studies reporting that high cholesterol is associated with decreased dementia in the oldest-old, we report that hypercholesterolemia was not associated with dementia while statin users were at decreased dementia risk. There are a variety of mechanisms by which statins may be neuroprotective including effects on amyloid production, neurofibrillary tangles, secondary stroke prevention, and other anti-inflammatory pleiotropic effects. Additional research is needed to explore other potential explanations for our results along with assessment of the effect of serum cholesterol levels and statin lipophil...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Evans, M., Kawas, C., Corrada, M. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Clinical Aspects Source Type: research

Helping Haiti: Addressing the Burden of Neurologic Disease (I10-2.004)
CONCLUSIONS: With this nationwide collaborative and interdisciplinary approach, we hope to have a dramatic impact on the perceptions and outcomes of neurologic disease and provide a continuous, but dynamic presence in Port au Prince, Haiti while training physicians, nurses, and other team members in global health perspectives.Disclosure: Dr. Santini has nothing to disclose. Dr. Alessi has received personal compensation for activities with CBS Radio, the National Football League Players Association, and Colonial Cooperative Care. Dr. Jones has nothing to disclose. Dr. Etienne has nothing to disclose. Dr. Hohler has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Santini, V., Alessi, A., Jones, E., Etienne, M., Hohler, A. Tags: The Global Burden of Neurological Diseases Data Blitz Presentations Source Type: research

Presence and progression of white matter hyperintensities and cognition: A meta-analysis
Conclusions: The small but robust and consistent effects of WMHs on all cognitive domains suggest a more global effect on cognition than previously thought. Progression of WMHs was associated with even worse cognitive functioning, most pronounced in attention and executive functioning.
Source: Neurology - June 9, 2014 Category: Neurology Authors: Kloppenborg, R. P., Nederkoorn, P. J., Geerlings, M. I., van den Berg, E. Tags: MRI, Other cerebrovascular disease/ Stroke, All Cognitive Disorders/Dementia, Assessment of cognitive disorders/dementia VIEWS & amp;amp; REVIEWS Source Type: research

Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife
Conclusions: Elevated IL-6 but not CRP in midlife predicts cognitive decline; the combined cross-sectional and longitudinal effects over the 10-year observation period corresponded to an age effect of 3.9 years.
Source: Neurology - August 4, 2014 Category: Neurology Authors: Singh-Manoux, A., Dugravot, A., Brunner, E., Kumari, M., Shipley, M., Elbaz, A., Kivimaki, M. Tags: All Cognitive Disorders/Dementia, Cognitive aging, Risk factors in epidemiology ARTICLE Source Type: research