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Rapid analysis of hypolipidemic drugs in a live zebrafish assay
In this study, taking advantage of the transparency of larval zebrafish, we developed a zebrafish hyperlipidemia model for drug screening and efficacy assessment. Zebrafish at 5 d.p.f (days post fertilization) were fed with 0.1% egg yolk for 48h (hours), followed by drug treatment for 24h or 48h. Tested drugs were administered into the zebrafish by direct soaking. Drug effect was evaluated based on quantitative analysis of Oil Red O (ORO) in zebrafish vena caudalis. Results All 5 human hypolipidemic drugs (simvastatin, lovastatin, ezetimibe, bezafibrate, hyodesoxycholic acid) showed significant hypolipidemic effects (p &a...
Source: Journal of Pharmacological and Toxicological Methods - December 13, 2014 Category: Drugs & Pharmacology Source Type: research