Filtered By:
Source: Am J Physiol Lung Ce...
Drug: Nicotine

This page shows you your search results in order of date.

Order by Relevance | Date

Total 74 results found since Jan 2013.

Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research

Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research

Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research

Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research

Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research

Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research

Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research

Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research

Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research

Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research

Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research

Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research

Functional α7 nicotinic receptors in human airway smooth muscle increase intracellular calcium concentration and contractility in asthmatics
This study demonstrates functional alpha7 nicotinic acetylcholine receptors (α7nAChRs) are expressed in human airway smooth muscle, including from asthmatics, and enhance intracellular calcium and contractility. Although a7nAChRs are associated with neuronal pathways, α7nAChR in smooth muscle suggests inhaled nicotine (e.g. vaping) can directly influence airway contractility. Targeting α7nAChR may represent a novel approach to alleviating airway hyperresponsiveness in asthma.PMID:37192375 | DOI:10.1152/ajplung.00260.2022
Source: Am J Physiol Lung Ce... - May 16, 2023 Category: Respiratory Medicine Authors: Latifa Khalfaoui Nuriya Mukhtasimova Brian Kelley Natalya Wells Jacob J Teske Benjamin B Roos Niyati A Borkar Emily Y Zhang Steven M Sine Y S Prakash Christina M Pabelick Source Type: research