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Source: Cell Research
Drug: Melatonin
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Total 82 results found since Jan 2013.
Proteomic Analysis Reveals the Neurotoxic Effects of Chronic Methamphetamine Self-Administration-Induced Cognitive Impairments and the Role of Melatonin-Enhanced Restorative Process during Methamphetamine Withdrawal
J Proteome Res. 2023 Sep 7. doi: 10.1021/acs.jproteome.3c00502. Online ahead of print.ABSTRACTCognitive flexibility is a crucial ability in humans that can be affected by chronic methamphetamine (METH) addiction. The present study aimed to elucidate the mechanisms underlying cognitive impairment in mice chronically administered METH via an oral self-administration method. Further, the effect of melatonin treatment on recovery of METH-induced cognitive impairment was also investigated. Cognitive performance of the mice was assessed using an attentional set shift task (ASST), and possible underlying neurotoxic mechanisms wer...
Source: Cell Research - September 7, 2023 Category: Cytology Authors: Tanthai Polvat Tanya Prasertporn Piyada Na Nakorn Supitcha Pannengpetch Wilasinee Suwanjang Jiraporn Panmanee Sukhonthar Ngampramuan Jennifer L Cornish Banthit Chetsawang Source Type: research
Melatonin attenuates chronic intermittent hypoxia-induced intestinal barrier dysfunction in mice
CONCLUSION AND IMPLICATIONS: Melatonin attenuated CIH-induced intestinal barrier dysfunction by regulating gut flora dysbiosis, mucosal epithelium integrity, and Th17 polarization via STAT3 signalling.PMID:37659335 | DOI:10.1016/j.micres.2023.127480
Source: Cell Research - September 2, 2023 Category: Cytology Authors: Xinyi Li Fan Wang Zhenfei Gao Weijun Huang Xiaoman Zhang Feng Liu Hongliang Yi Jian Guan Xiaolin Wu Huajun Xu Shankai Yin Source Type: research
Differentiation of T cells producing interleukin-17 (Th17) against the background of exogenous melatonin during pregnancy
J Pineal Res. 2023 Aug 21:e12904. doi: 10.1111/jpi.12904. Online ahead of print.ABSTRACTThe population of T lymphocytes producing IL-17 (Th17) plays a dual role during pregnancy and its activity is tightly controlled during this period. One of the factors involved in this process may be the pineal hormone melatonin, which can effectively regulate this T cell population. Here we have shown that exogenous melatonin in pharmacological concentrations is able to enhance the differentiation of Th17 cells of pregnant women in vitro. The stimulatory effects of melatonin were limited to in the first trimester of pregnancy and were ...
Source: Cell Research - August 21, 2023 Category: Cytology Authors: Natalya Sergeevna Glebezdina Irina Valerievna Nekrasova Anna Alexandrovna Olina Gulnara Kamilyevna Sadykova Elena Michajlovna Kuklina Source Type: research
Efficacy, mechanism and safety of melatonin-loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: a novel design
This article is protected by copyright. All rights reserved.PMID:37492880 | DOI:10.1111/jpi.12900
Source: Cell Research - July 26, 2023 Category: Cytology Authors: Lei Chen Tao Sun Yongning Lv Xin Lu Xixuan Li Hongsen Zhang Kun Qian Xiaopeng Guo Bo Sun Weihua Zhang Licheng Zhu Jia Huang Yiming Liu Huangxuan Zhao Yanbin Zhao Bin Liang Chuansheng Zheng Source Type: research
Using Human 'Personalized' Cybrids to Identify Drugs/Agents That Can Regulate Chronic Lymphoblastic Leukemia Mitochondrial Dysfunction
This study uses personalized chronic lymphoblastic leukemia (CLL) cybrid cells to test various drugs/agents designed to improve mitochondrial function and cell longevity. Age-matched control (NL) and CLL cybrids were created. The NL and CLL cybrids were treated with ibrutinib (Ibr-10 μM), mitochondrial-targeted nutraceuticals such as alpha lipoic acid (ALA-1 mM), amla (Aml-300 μg), melatonin (Mel-1 mM), resveratrol (Res-100 μM) alone, or a combination of ibrutinib with nutraceuticals (Ibr + ALA, Ibr + Aml, Ibr + Mel, or Ibr + Res) for 48 h. MTT (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazoliumbromide), H2DCFDA(2',7' ...
Source: Cell Research - July 14, 2023 Category: Cytology Authors: Lata Singh Shari Atilano Marilyn Chwa Mithalesh K Singh Mustafa Ozgul Anthony Nesburn M Cristina Kenney Source Type: research
Exogenous melatonin ameliorates steroid-induced osteonecrosis of the femoral head by modulating ferroptosis through GDF15-mediated signaling
CONCLUSIONS: We proposed that MT attenuated SONFH by inhibiting ferroptosis through the regulation of GDF15, and supplementation with exogenous MT might be a promising method for the treatment of SONFH.PMID:37400902 | DOI:10.1186/s13287-023-03371-y
Source: Cell Research - July 3, 2023 Category: Cytology Authors: Wenming Li Wenhao Li Wei Zhang Hongzhi Wang Lei Yu Peng Yang Yi Qin Minfeng Gan Xing Yang Lixin Huang Yuefeng Hao Dechun Geng Source Type: research
Melatonin enhances cell death and suppresses the metastatic capacity of ovarian cancer cells by attenuating the signaling of multiple kinases
CONCLUSIONS: Melatonin had obvious oncostatic actions on ovarian cancer cells, and MT1 receptor knockdown intensified its antitumor effect. The inhibition of the MT1 receptor resulted in a substantial reduction in the migratory and invasive capacities of the cells, suggesting its potential as a therapeutic target for the treatment of ovarian cancer.PMID:37356221 | DOI:10.1016/j.prp.2023.154637
Source: Cell Research - June 25, 2023 Category: Cytology Authors: Maira Smaniotto Cucielo Paula Paccielli Freire Maycon Tavares Em ílio-Silva Graziela Gorete Romagnoli Robson Francisco Carvalho Ramon Kaneno Cl élia Akiko Hiruma-Lima Fl ávia Karina Delella Russel J Reiter Luiz Gustavo de Almeida Chuffa Source Type: research
Tumor microenvironment remodeling in oral cancer: Application of plant derived-natural products and nanomaterials
Environ Res. 2023 Jun 16:116432. doi: 10.1016/j.envres.2023.116432. Online ahead of print.ABSTRACTOral cancers consist of squamous cell carcinoma (SCC) and other malignancies in the mouth with varying degrees of invasion and differentiation. For many years, different modalities such as surgery, radiation therapy, and classical chemotherapy drugs have been used to control the growth of oral tumors. Nowadays, studies have confirmed the remarkable effects of the tumor microenvironment (TME) on the development, invasion, and therapeutic resistance of tumors like oral cancers. Therefore, several studies have been conducted to m...
Source: Cell Research - June 18, 2023 Category: Cytology Authors: Hendrik Setia Budi Bagher Farhood Source Type: research
Alleviation of cadmium-induced photoinhibition and oxidative stress by melatonin in Chlamydomonas reinhardtii
Environ Sci Pollut Res Int. 2023 Jun 3. doi: 10.1007/s11356-023-27561-6. Online ahead of print.ABSTRACTAs one of the most threatening challenges to the natural environment and human health, cadmium (Cd) pollution has seriously impacted natural organisms. Green algae, such as Chlamydomonas reinhardtii (C. reinhardtii), can provide a safer, lower cost, and more effective ecological approach to the treatment of heavy metal ions in wastewater due to their sorption properties. However, heavy metal ions affect C. reinhardtii when adsorbed. Melatonin is able to protect the plant body from damage when the plant is under biotic/abi...
Source: Cell Research - June 3, 2023 Category: Cytology Authors: Fangbing Qi Yu Gao Jiaqi Liu Xiangyu Yao Kai Han Ziyi Wu Yingjuan Wang Source Type: research
Melatonin attenuates lung ischemia-reperfusion injury through SIRT3 signaling-dependent mitophagy in type 2 diabetic rats
Conclusion: Data indicated that melatonin attenuates diabetic LIRI through activation of SIRT3 signaling-mediated mitophagy.PMID:37265380 | DOI:10.1080/01902148.2023.2213335
Source: Cell Research - June 2, 2023 Category: Cytology Authors: Zhiqiang Song Congmin Yan Yuanbo Zhan Qiujun Wang Yina Zhang Tao Jiang Source Type: research
Effect of Melatonin on ATG2B-mediated Autophagy Regulation in Sheep Granulosa Cells with Different Fec < sup > B < /sup > Genotypes
In conclusion, this study determined that autophagy levels were significantly higher in sheep GCs with FecB BB genotype than the levels in those with FecB ++ genotype, which may have contributed to the difference in lambing numbers between the two FecB genotypes. Autophagy was regulated by ATG2B and was able to protect GCs by reducing the high levels of ROS produced following inhibition of ATG2B through the addition of MLT in vitro. This article is protected by copyright. All rights reserved.PMID:37226314 | DOI:10.1111/jpi.12890
Source: Cell Research - May 25, 2023 Category: Cytology Authors: Yu-Fang Liu Zi-Yi Liu Wen-Tao Li Peng Wang Xiang-Yu Wang Ran Di Xiao-Yun He Ming-Xing Chu Source Type: research
Seed pretreatment with melatonin confers cadmium tolerance to chickpea seedlings through cellular redox homeostasis and antioxidant gene expression improvement
Environ Sci Pollut Res Int. 2023 May 16. doi: 10.1007/s11356-023-27562-5. Online ahead of print.ABSTRACTSeveral phytoremediation strategies have been undertaken to alleviate cadmium (Cd)-mediated injury to crop yield resulting from agricultural land pollution. In the present study, the potentially beneficial effect of melatonin (Me) was appraised. Therefore, chickpea (Cicer arietinum L.) seeds were imbibed for 12 H in distilled water or Me (10 µM) solution. Then, the seeds germinated in the presence or the absence of 200 µM CdCl2 for 6 days. Seedlings obtained from Me-pretreated seeds exhibited enhanced growth traits, re...
Source: Cell Research - May 16, 2023 Category: Cytology Authors: Lamia Sakouhi Oumayma Kadri Sirine Werghi Marouane Ben Massoud Oussama Kharbech Yoshiyuki Murata Abdelilah Chaoui Source Type: research
Melatonin acts synergistically with pazopanib against renal cell carcinoma cells through p38 mitogen-activated protein kinase-mediated mitochondrial and autophagic apoptosis
CONCLUSION: The combination of melatonin and pazopanib inhibits the growth of RCC cells by inducing p38MAPK-mediated mitochondrial and autophagic apoptosis. Therefore, melatonin might be a potential adjuvant that could act synergistically with pazopanib for RCC treatment.PMID:37165617 | DOI:10.23876/j.krcp.22.114
Source: Cell Research - May 11, 2023 Category: Cytology Authors: Chien-Pin Lai Yong-Syuan Chen Tsung-Ho Ying Cheng-Yen Kao Hui-Ling Chiou Shao-Hsuan Kao Yi-Hsien Hsieh Source Type: research
Investigation of the anti-oxidative and anti-inflammatory effects of melatonin on experimental liver damage by radiation
Pathol Res Pract. 2023 Apr 25;246:154477. doi: 10.1016/j.prp.2023.154477. Online ahead of print.ABSTRACTRadiotherapy is one of the inevitable treatment approaches for several types of cancer. We aimed to show the protective and therapeutic effects of daily use of melatonin on liver tissues subjected to a single dose of 10 Gy (gamma-ray) total body radiation. Rats were divided into 6 groups, of which 10 were in each: control, sham, melatonin, radiation, radiation+melatonin, and melatonin+radiation. The rats received 10 Gy of external radiation throughout their entire bodies. The rats were given 10 mg/kg/day of melatonin int...
Source: Cell Research - May 6, 2023 Category: Cytology Authors: Betul Yalcin Arzu Han ım Yay Fazile Cant ürk Tan Saim Özdamar O ğuz Galip Yildiz Source Type: research
Effects of hormones on intestinal stem cells
Stem Cell Res Ther. 2023 Apr 26;14(1):105. doi: 10.1186/s13287-023-03336-1.ABSTRACTThe maintenance of intestinal renewal and repair mainly depends on intestinal stem cells (ISCs), which can also contribute to the growth of intestinal tumours. Hormones, which are vital signalling agents in the body, have various effects on the growth and replacement of intestinal stem cells. This review summarises recent progress in the identification of hormones associated with intestinal stem cells. Several hormones, including thyroid hormone, glucagon-like peptide-2, androgens, insulin, leptin, growth hormone, corticotropin-releasing hor...
Source: Cell Research - April 26, 2023 Category: Cytology Authors: Li Liu Lilong Zhang Chunlei Li Zhendong Qiu Tianrui Kuang Zhongkai Wu Wenhong Deng Source Type: research
