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This ECG is nearly pathognomonic. What is it? (hint: it ' s not Wellens ' )
I was texted this ECG:What did I say?My response: " takotusubo "Even without a history, this is the likely diagnosis.  Later, I obtained the history: 60-something woman who presented with agitation and had taken a benzodiazepine overdose.  There was no report of chest pain.  She had a respiratory alkalosis, with venous pH of 7.56 (equivalent to an arterial pH of higher than 7.60 and possibly contributing to the long QT and ECG abnormalities).  Electrolytes were normal.  She was also on Duloxetine, which can prolong the QT, and on Lithium (but her level was very low).This is almost certainly ta...
Source: Dr. Smith's ECG Blog - September 19, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs

Cardioprotective effects of amiodarone in a rat model of epilepsy-induced cardiac dysfunction
Clin Exp Pharmacol Physiol. 2021 Nov 19. doi: 10.1111/1440-1681.13615. Online ahead of print.ABSTRACTCardiac dysfunction is one of the leading causes of death in epilepsy. The anti-arrhythmic drug, amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups (1) Control, (2) Control-lithium and (3) Control-Amio, treated with 150 mg/kg/intraperitoneal amiodarone, (4) Epilepsy model, induced by sequ...
Source: Clinical and Experimental Pharmacology and Physiology - November 19, 2021 Category: Drugs & Pharmacology Authors: Inas A Harb Hend Ashour Abeer Mostafa Hala M El Hanbuli Eman Hassan Nadwa Source Type: research

Lithium ‐induced electrocardiographic changes: A complete review
Lithium has been used for the treatment of bipolar disorder for more than 6 decades. Reports of cardiac side effects resulting in both benign electrocardiographic (ECG) changes and near fatal arrhythmias have been reported in the literature. A systematic literature search was conducted on 2 electronic databases—PubMed and Medline—for the time period between January 1970 and March 2016 using the key word “lithium,” along with “electrocardiography” or “ECG.” All articles and their references were then screened by title for relevance by 2 authors and a librarian. A total of 406 articles were found on literatur...
Source: Clinical Cardiology - December 16, 2017 Category: Cardiology Authors: Nikhil Mehta, Robert Vannozzi Tags: REVIEW Source Type: research