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Atorvastatin inhibits miR-143 expression: A protective mechanism against oxidative stress in cardiomyocytes
Statins are unequivocally the most widely prescribed drug for the primary and secondary prevention of coronary artery disease worldwide [1]. Atorvastatin is the most commonly prescribed statin drug due to its lower therapeutic dose comared to others. The well-tolerated and high benefit–risk ration of atorvastain has been demonstrated in clinical trials [2]. Atorvastatin reduce the risk of myocardial infarction, stroke, and death, primarily inhibiting reactive oxygen species (ROS) [3].
Source: International Journal of Cardiology - March 1, 2016 Category: Cardiology Authors: Shanshan Tian, Wei Zhao, Di Yang, Yang Yu, Jiaqi Zou, Zhiyan Liu, Zhimin Du Tags: Correspondence Source Type: research

High dose atorvastatin therapy yields a better carotid atherosclerosis improvement in Chinese patients
Statins is one of key components in the cocktail of medications for the treatment of patients with atherosclerosis and have proved to reduce vascular events significantly in primary and secondary prevention of coronary heart disease (CHD) in the past decades [1–3]. As the most widely used statins, the effectiveness of atorvastatin in lowering LDL-C has been demonstrated in several trials [4,5]. Plasma LDL-C levels and carotid intima-media thickness (IMT) have been proved associated with incidence of stroke [6].
Source: International Journal of Cardiology - March 11, 2015 Category: Cardiology Authors: Yafeng Li, Shoucui Gao, Yingfeng An, Enqi Liu, Sihai Zhao Source Type: research