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Insulin-Like Growth Factor 2 (IGF-2) Regulates Neuronal Density and IGF-2 Distribution Following Hippocampal Intracerebral Hemorrhage
Memory is the most critical cognitive function in humans. Hippocampus infarcts and artery lesions in stroke and trauma cause levels of memory loss, and it is an apparent cause of disability in the communities.1,2 Intracerebral Hemorrhage (ICH) caused by bleeding in the brain parenchyma and penetration of the hematoma into the hippocampus leads to severe memory damage.3,4 Many arteries supply the hippocampus, most of which branch off of the posterior cerebral artery, the anterior temporal, and the anterior choroidal arteries.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Farzaneh Vafaee, Asadollah Zarifkar, Masoumeh Emamghoreishi, Mohammad Reza Namavar, Shima Shirzad, Hamed Ghazavi, Vahid Mahdavizadeh Source Type: research

Potential Application of Intranasal Insulin Delivery for Treatment of Intracerebral Hemorrhage: A Review of The Literature
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke associated with high morbidity and mortality that is considered a medical emergency, mainly managed with adequate blood pressure control and creating a favorable hemostatic condition. However, to date, none of the randomized clinical trials have led to an effective treatment for ICH. It is vital to better understand the mechanisms underlying brain injury to effectively decrease ICH-associated morbidity and mortality. It is well known that initial hematoma formation and its expansion have detrimental consequences.
Source: Journal of Stroke and Cerebrovascular Diseases - April 27, 2022 Category: Neurology Authors: Muhammad Ali Javaid, Magdy Selim, Santiago Ortega-Gutierrez, Simona Lattanzi, Shima Zargar, Danielle A Alaouieh, Emily Hong, Afshin A. Divani Tags: Review Article Source Type: research

Central vs site outcome adjudication in the IRIS trial
Central adjudication of outcome events is the standard in clinical trial research. We examine the benefit of central adjudication in the Insulin Resistance Intervention after Stroke (IRIS) trial and show how the benefit is influenced by outcome definition and features of the adjudicated events.
Source: Journal of Stroke and Cerebrovascular Diseases - July 25, 2022 Category: Neurology Authors: Rachel Forman, Catherine M. Viscoli, Philip M. Bath, Karen L. Furie, Peter Guarino, Silvio E. Inzucchi, Lawrence Young, Walter N. Kernan Source Type: research

Positive Association Between Serum Insulin-Like Growth Factor-1 and Cognition in Patients with Cerebral Small Vessel Disease
Cognitive impairment is one of the main complications of cerebral small vessel disease (CSVD). Serum insulin-like growth factor-1 (IGF-1) might serve as a marker for the risk of cognitive decline in patients with CSVD. We investigated the association of IGF-1 with the development of cognitive impairment in patients with CSVD. We included 216 patients with CVSD (mean age, 67.57  ± 8.53 years; 31.9% female). We compared 117 (54.2%) patients who developed cognitive impairment with 99 (45.8%) patients without cognitive impairment.
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2021 Category: Neurology Authors: Jingwen Kang, Wenqiu Luo, Cuiwei Zhang, Yi Ren, Liping Cao, Jian Wu, Huajie Li Source Type: research

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