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Source: Vitamins and Hormones
Drug: Insulin
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Total 513 results found since Jan 2013.
Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2
Vitam Horm. 2023;123:187-230. doi: 10.1016/bs.vh.2023.01.010. Epub 2023 Mar 1.ABSTRACTElucidating how insulin and the related insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) bind to their cellular receptors (IR and IGF-1R) and how the receptors are activated has been the holy grail for generations of scientists. However, deciphering the 3D structure of tyrosine kinase receptors and their hormone-bound complexes has been complicated by the flexible and dimeric nature of the receptors and the dynamic nature of their interaction with hormones. Therefore, mutagenesis of hormones and kinetic studies first became an import...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Ji ří Jiráček Irena Selicharov á Lenka Žáková Source Type: research
The three-dimensional structure of insulin and its receptor
Vitam Horm. 2023;123:151-185. doi: 10.1016/bs.vh.2022.12.001. Epub 2023 Jun 5.ABSTRACTInsulin is a peptide hormone essential for maintaining normal blood glucose levels. Individuals unable to secrete sufficient insulin or not able to respond properly to insulin develop diabetes. Since the discovery of insulin its structure and function has been intensively studied with the aim to develop effective diabetes treatments. The three-dimensional crystal structure of this 51 amino acid peptide paved the way for discoveries, outlined in this review, of determinants important for receptor binding and hormone stability that have bee...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Briony E Forbes Source Type: research
Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2
Vitam Horm. 2023;123:187-230. doi: 10.1016/bs.vh.2023.01.010. Epub 2023 Mar 1.ABSTRACTElucidating how insulin and the related insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) bind to their cellular receptors (IR and IGF-1R) and how the receptors are activated has been the holy grail for generations of scientists. However, deciphering the 3D structure of tyrosine kinase receptors and their hormone-bound complexes has been complicated by the flexible and dimeric nature of the receptors and the dynamic nature of their interaction with hormones. Therefore, mutagenesis of hormones and kinetic studies first became an import...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Ji ří Jiráček Irena Selicharov á Lenka Žáková Source Type: research
The three-dimensional structure of insulin and its receptor
Vitam Horm. 2023;123:151-185. doi: 10.1016/bs.vh.2022.12.001. Epub 2023 Jun 5.ABSTRACTInsulin is a peptide hormone essential for maintaining normal blood glucose levels. Individuals unable to secrete sufficient insulin or not able to respond properly to insulin develop diabetes. Since the discovery of insulin its structure and function has been intensively studied with the aim to develop effective diabetes treatments. The three-dimensional crystal structure of this 51 amino acid peptide paved the way for discoveries, outlined in this review, of determinants important for receptor binding and hormone stability that have bee...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Briony E Forbes Source Type: research
Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2
Vitam Horm. 2023;123:187-230. doi: 10.1016/bs.vh.2023.01.010. Epub 2023 Mar 1.ABSTRACTElucidating how insulin and the related insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) bind to their cellular receptors (IR and IGF-1R) and how the receptors are activated has been the holy grail for generations of scientists. However, deciphering the 3D structure of tyrosine kinase receptors and their hormone-bound complexes has been complicated by the flexible and dimeric nature of the receptors and the dynamic nature of their interaction with hormones. Therefore, mutagenesis of hormones and kinetic studies first became an import...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Ji ří Jiráček Irena Selicharov á Lenka Žáková Source Type: research
The three-dimensional structure of insulin and its receptor
Vitam Horm. 2023;123:151-185. doi: 10.1016/bs.vh.2022.12.001. Epub 2023 Jun 5.ABSTRACTInsulin is a peptide hormone essential for maintaining normal blood glucose levels. Individuals unable to secrete sufficient insulin or not able to respond properly to insulin develop diabetes. Since the discovery of insulin its structure and function has been intensively studied with the aim to develop effective diabetes treatments. The three-dimensional crystal structure of this 51 amino acid peptide paved the way for discoveries, outlined in this review, of determinants important for receptor binding and hormone stability that have bee...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Briony E Forbes Source Type: research
DNA methylation in the pathogenesis of type 2 diabetes
Vitam Horm. 2023;122:147-169. doi: 10.1016/bs.vh.2022.11.002. Epub 2022 Dec 16.ABSTRACTType 2 diabetes (T2D) is a metabolic disease characterized by the development of β-cell dysfunction with hepatic, muscular and adipose tissue insulin resistance. Although the molecular mechanisms leading to its development are not entirely known, investigations of its causes reveal a multifactorial contribution to its development and progression in most cases. In addition, regulatory interactions mediated by epigenetic modifications such as DNA methylation, histone tail modifications and regulatory RNAs have been found to play a signifi...
Source: Vitamins and Hormones - March 2, 2023 Category: Endocrinology Authors: Suneesh Kaimala Suraiya Anjum Ansari Bright Starling Emerald Source Type: research
