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Drug-induced liver injury with commonly used antibiotics in the All of Us Research Program
Clin Pharmacol Ther. 2023 May 7. doi: 10.1002/cpt.2930. Online ahead of print.ABSTRACTAntibiotics are a known cause of idiosyncratic drug-induced liver injury (DILI). According to CDC, the five most commonly prescribed antibiotics in the United States are azithromycin, ciprofloxacin, cephalexin, amoxicillin, and amoxicillin-clavulanate. We quantified the frequency of acute DILI for these common antibiotics in the All of Us Research Program, one of the largest Electronic Health Record (EHR)-linked research cohorts in the United States. Retrospective analyses were conducted applying a standardized phenotyping algorithm to de...
Source: Clinical Pharmacology and Therapeutics - May 8, 2023 Category: Drugs & Pharmacology Authors: Shaopeng Gu Govarthanan Rajendiran Kennedy Forest Tam C Tran Joshua C Denny Eric A Larson Russell A Wilke Source Type: research

A retrospective review of Achromobacter species and antibiotic treatments in patients with primary ciliary dyskinesia
Conclusion The prevalence of Achromobacter species in patients with PCD is in line with what has been reported in cystic fibrosis and can occur transiently, intermittently, or develop into a serious persistent lung infection associated with long-term antibiotic treatment.PMID:34854775 | PMC:PMC8646779 | DOI:10.1177/14799731211061600
Source: Chronic Respiratory Disease - December 2, 2021 Category: Respiratory Medicine Authors: Mathias G Holgersen June K Marthin Helle K Johansen Kim G Nielsen Source Type: research