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A systematic review on extracorporeal shock wave therapy and botulinum toxin for spasticity treatment: a comparison on efficacy
CONCLUSIONS: A beneficial effect on spasticity was found for both treatments: evidence showed that ESWT and BoNT-A can ameliorate spasticity considering parameters such as MAS, MTS, AROM, PROM, UE-FMA, VAS and SFS in post-stroke, multiple sclerosis, and cerebral palsy patients. Further research is required to strengthen the evidence, and more suitable study protocols are highly needed.PMID:35412036 | DOI:10.23736/S1973-9087.22.07136-2
Source: European Journal of Physical and Rehabilitation Medicine - April 12, 2022 Category: Rehabilitation Authors: Emanuela E Mihai Marius N Popescu Alina N Iliescu Mihai Berteanu Source Type: research

Clinical Onset of Action of Incobotulinum Toxin A Preparation
CONCLUSION: This study demonstratedthe onset of IncobotulinumtoxinA efficacy started after 7 days; this rapid action and efficacy of BoNT/A preparation could improve an intensive rehabilitation program after some days post injection. Early clinical onset of action could be by the absence of complexing proteins in the preparation.PMID:35786195 | DOI:10.2174/1871527321666220630154404
Source: CNS and Neurological Disorders Drug Targets - July 5, 2022 Category: Drugs & Pharmacology Authors: Riccardo Marvulli Maurizio Ranieri Laura Belinda Rizzo Francesco Marra Giancar Lo Ianieri Marisa Megna Source Type: research

Po-01-167 efficacy of botulinum toxin type a (agn-151607) for the prevention of postoperative atrial fibrillation in cardiac surgery patients: atrial fibrillation and anticoagulation results from the phase 2 nova study
Oral anticoagulation reduces the risk of stroke but also increases the risk of bleeding. Prevention of post-operative atrial fibrillation (POAF) could result in a lower burden of oral anticoagulation and bleeding events. AGN-151607 has been proposed to prevent POAF and its safety/efficacy was tested in a multicenter randomized trial.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Nathan Waldron, Alexandra OSullivan, Jonathan P. Piccini, Matthew Romano, Pierre Voisine, Wilson Titanji, Richard Leaback, William Ferguson, Jonathan S. Steinberg Source Type: research

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