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Studies on the animal model of post-stroke depression and application of antipsychotic aripiprazole.
Abstract We investigated the question of whether an animal model of post-stroke depression in ischemic stroke can be developed by additional chronic mild stress (CMS) procedures. Behavioral and histopathological analysis was performed for examination of the depressive disorders in CMS, left middle cerebral artery occlusion (MCAO) and CMS after MCAO (MCAO+CMS) in mice. In all depressant screening tests involving open field, sucrose preference, forced swim and Morris water maze test, MCAO+CMS mice showed more significant depressive behaviors than MCAO mice. MCAO+CMS mice also showed distinct deficits in forced swim ...
Source: Behavioural Brain Research - April 3, 2015 Category: Neurology Authors: Kim YR, Kim HN, Pak ME, Ahn SM, Hong KH, Shin HK, Choi BT Tags: Behav Brain Res Source Type: research