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Source: Acta Biochimica et Biophysica Sinica
Drug: Docetaxel
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Total 55 results found since Jan 2013.
miR-1205/DNAJB1 reverses docetaxel chemoresistance in human triple negative breast carcinoma cells via regulation of mutp53/TAp63 signaling
In this study, we aimed to investigate the molecular mechanism behind DOC chemoresistance and the possible therapeutic effects of miRNAs. Utilizing qRT-PCR analysis, we discovered that miR-1205 is gradually downregulated in human triple negative breast carcinoma MDA-MB-231 and docetaxel-resistant MDA-MB-231 (MDA-MB-231/DOC) cells compared with Hs 578Bst normal human breast fibroblasts. Cell viability, cell cycle and apoptosis assays in MDA-MB-231/DOC cells indicated that miR-1205 overexpression enhances docetaxel sensitivity by reducing cell viability as well as inducing G2/M cell cycle arrest and cell apoptosis. Western b...
Source: Acta Biochimica et Biophysica Sinica - February 7, 2022 Category: Biochemistry Authors: Yongxiang Yin Jinqiu Zhang Tao Ma Daozhen Chen Daru Lu Source Type: research
