• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Identification of integrative hepatotoxicity induced by lysosomal phospholipase A2 inhibition of cationic amphiphilic drugs via metabolomics
Biochem Biophys Res Commun. 2022 Mar 25;607:1-8. doi: 10.1016/j.bbrc.2022.03.038. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) is a condition caused by drugs that leads to abnormal hepatic function. Hepatotoxicity caused by DILI has been shown to be due to cellular stress, mitochondrial dysfunction, cell necrosis and apoptosis and many types of hepatotoxicity, such as phospholipidosis, steatosis and hepatitis, commonly share intracellular molecular mechanisms. Metabolomics can be useful for mechanism-based toxicity evaluations and has been recently utilized as a scientific technique that can effectively p...
Source: Cell Research - March 31, 2022 Category: Cytology Authors: Hyun-A Oh Ye-Ji Kim Kyoung-Sik Moon Joung-Wook Seo Byung Hwa Jung Dong Ho Woo Source Type: research

Selective estrogen receptor modulators limit alphavirus infection by targeting the viral capping enzyme nsP1
Antimicrob Agents Chemother. 2022 Jan 18:AAC0194321. doi: 10.1128/AAC.01943-21. Online ahead of print.ABSTRACTAlphaviruses cause animal or human diseases that are characterized by febrile illness, debilitating arthralgia, or encephalitis. Selective estrogen receptor modulators (SERMs), a class of FDA-approved drugs, have been shown to possess antiviral activities against multiple viruses, including Hepatitis C virus, Ebola virus, dengue virus, and vesicular stomatitis virus. Here, we evaluated three SERM compounds, namely 4-hydroxytamoxifen, tamoxifen, and clomifene, for plausible antiviral properties against two medically...
Source: Antimicrobial Agents and Chemotherapy - January 18, 2022 Category: Microbiology Authors: Rajat Mudgal Chandrima Bharadwaj Aakriti Dubey Shweta Choudhary Perumal Nagarajan Megha Aggarwal Yashika Ratra Soumen Basak Shailly Tomar Source Type: research