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Infectious Disease: Diphtheria
Drug: Tamoxifen
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Total 3 results found since Jan 2013.
Partial Ablation of Astrocytes Exacerbates Cerebral Infiltration of Monocytes and Neuronal Loss After Brain Stab Injury in Mice
In this study, we used a forebrain stab injury mouse model to investigate the pathological role of reactive astrocytes in cellular and molecular changes of inflammatory response following TBI. In the ipsilateral hemisphere of stab-injured brain, monocyte infiltration and neuronal loss, as well as increased elevated astrogliosis, microglia activation and inflammatory cytokines were observed. To verify the role of reactive astrocytes in TBI, local and partial ablation of astrocytes was achieved by stereotactic injection of diphtheria toxin in the forebrain of Aldh1l1-CreERT2::Ai9::iDTR transgenic mice which expressed diphthe...
Source: Cellular and Molecular Neurobiology - April 19, 2022 Category: Cytology Authors: Xia Hu Shaojian Li Zhongshan Shi Wei-Jye Lin Yuhua Yang Yi Li Honghong Li Yongteng Xu Meijuan Zhou Yamei Tang Source Type: research
