Filtered By:
Source: Cell Research
Drug: Tamoxifen
This page shows you your search results in order of date.
Order by Relevance | Date
Total 63 results found since Jan 2013.
Genetic inactivation of β-catenin is salubrious whereas its activation is deleterious in desmoplakin cardiomyopathy
CONCLUSION: The cWNT/β-catenin was markedly dysregulated in the cardiac myocytes in a mouse model of desmoplakin cardiomyopathy. Inactivation of β-catenin attenuated whereas its activation aggravated the phenotype, through multiple molecular pathways, independent of the cWNT transcriptional activity. Thus, suppression but not activation of β-catenin might be beneficial in desmoplakin cardiomyopathy.PMID:37625794 | DOI:10.1093/cvr/cvad137
Source: Cell Research - August 25, 2023 Category: Cytology Authors: Melis Olcum Siyang Fan Leila Rouhi Sirisha Cheedipudi Benjamin Cathcart Hyun-Hwan Jeong Zhongming Zhao Priyatansh Gurha Ali J Marian Source Type: research
Effect of Tamoxifen on Proteome Expression during < em > In Vitro < /em > Myogenesis in Murine Skeletal Muscle C < sub > 2 < /sub > C < sub > 12 < /sub > Cells
We report a tandem mass-tag approach to TMX-treated myogenesis in C2C12 cells, a well-characterized model of in vitro murine skeletal muscle differentiation. A longitudinal analysis of >10,000 proteins identified in untreated C2C12 myogenesis revealed a novel subset of 1,062 myogenically regulated proteins. These proteins clustered into five distinct longitudinal expression trends which significantly overlap those obtained in similar analyses performed in human myocytes. We document a specific functional enrichment for adiponectin-signaling unique to TMX-treated myogenesis, as well as a subset of 198 proteins that are d...
Source: Cell Research - August 8, 2023 Category: Cytology Authors: Emily A Morris Ahlenne Abreu Stylianos P Scordilis Source Type: research
Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice
In this study, we applied in vivo fluorescent tracing using NestinCreERT2::Rosa26-tdTomato mice and analyzed the endogenous neurogenesis lineage progression of neural stem cells (NSCs) and dendritic spine formation of newborn neurons in the subgranular zone of the dentate gyrus. We found abnormal orientation of tamoxifen-induced tdTomato+ (tdTom+) NSCs in adult mice 2 months after treatment with EtOH (5.0 g/kg, i.p.) for 7 consecutive days. EtOH markedly inhibited tdTom+ NSCs activation and hippocampal neurogenesis in mouse dentate gyrus from adolescence to adulthood. EtOH (100 mM) also significantly inhibited the prolifer...
Source: Cell Research - July 25, 2023 Category: Cytology Authors: Guixiang Wang Wenjia Wang Ye Zhang Xiaoying Gou Qingqing Zhang Yanmiao Huang Kuo Zhang Haotian Zhang Jingyu Yang Yuting Li Source Type: research
LncRNA AGPG confers endocrine resistance in breast cancer by promoting E2F1 activity
Cancer Res. 2023 Jul 18:CAN-23-0015. doi: 10.1158/0008-5472.CAN-23-0015. Online ahead of print.ABSTRACTResistance to endocrine therapy represents a major concern for patients with estrogen receptor α positive (ERα+) breast cancer. Endocrine therapy resistance is commonly mediated by activated E2F signaling. A better understanding of the mechanisms governing E2F1 activity in resistant cells could reveal strategies for overcoming resistance. Here, we identified the long non-coding RNA (lncRNA) actin gamma 1 pseudogene 25 (AGPG) as a regulator of E2F1 activity in endocrine resistant breast cancer. Expression of EGPG was inc...
Source: Cell Research - July 18, 2023 Category: Cytology Authors: Shiyi Yu Ying Wang Xue Gong Zhehao Fan Zheng Wang Zhengyan Liang Rui Wu Binjie Cao Ning Wang Caili Bi Dan Lv Haibo Sun Source Type: research
EZH2 Expression and Survival for ER+/tamoxifen Treated Breast Cancer Patients with rs2302427 C & gt;G: A Novel Prognostic and Risk Predictive Biomarker
CONCLUSIONS: Three significant findings of the SNP rs.2302427C>G (Asp193His) i.e., protective role against breast cancer, survival advantage in ER+/tamoxifen treated breast cancer patients, and decreased expression due to the presence of mutant GG genotype, suggests considering it as an important prognostic biomarker for a good survival outcome of breast cancer patients treated with ER+/tamoxifen. Compared with other studies, the other SNP rs.3757441T>C was observed to have a protective effect in breast cancer biology but plays an antagonistic role in colorectal cancer (CRC) biology. To our knowledge, this is the fir...
Source: Cell Research - July 12, 2023 Category: Cytology Authors: Nisha Gautam Satbir Kaur Surender Kashyap Source Type: research
RNA interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction
CONCLUSIONS: Our results confirm the translational potential of RUNX1 as a novel therapeutic target in myocardial infarction, with wider opportunities for use across a range of cardiac diseases where RUNX1 drives adverse cardiac remodelling.PMID:37433039 | DOI:10.1093/cvr/cvad107
Source: Cell Research - July 11, 2023 Category: Cytology Authors: Tamara P Martin Eilidh A MacDonald Ashley Bradley Holly Watson Priyanka Saxena Eva A Rog-Zielinska Anmar Raheem Simon Fisher Ali Ali Mohamed Elbassioni Ohood Almuzaini Catriona Booth Morna Campbell Alex Riddell Pawel Herzyk Karen Blyth Colin Nixon Lorena Source Type: research
Suppression of breast cancer: modulation of estrogen receptor and downregulation of gene expression using natural products
Nat Prod Res. 2023 Jul 10:1-10. doi: 10.1080/14786419.2023.2232926. Online ahead of print.ABSTRACTThe main cause of cancer death among women is breast cancer. The most common type of breast cancer is the estrogen receptor positive breast cancer. Discovery of estrogen receptor provided a highly effective target for treatment of hormone-dependent breast cancer. Selective estrogen receptor inhibitors are useful for halting the growth of breast cancer cells and inducing apoptosis. Tamoxifen, a popular selective estrogen receptor modulator, can treat breast cancer but also has unfavourable side effects due to its estrogenic act...
Source: Cell Research - July 10, 2023 Category: Cytology Authors: Haidy Ahmed Alyaa Abdelraheem Mona Salem Martha Sabry Nada Fekry Fatma Mohamed Ahmed Saber Diletta Piatti Miral Sabry Omar Sabry Giovanni Caprioli Source Type: research
NO-sensitive guanylyl cyclase discriminates pericyte-derived interstitial from intra-alveolar myofibroblasts in murine pulmonary fibrosis
CONCLUSION: In summary, αSMA/PDGFRβ-positive myofibroblasts should not be addressed as a homogeneous target cell type within pulmonary fibrosis.PMID:37349733 | DOI:10.1186/s12931-023-02479-2
Source: Cell Research - June 22, 2023 Category: Cytology Authors: Annemarie Aue Nils Englert Leon Harrer Fabian Schwiering Annika Gaab Peter K önig Ralf Adams Achim Schmidtko Andreas Friebe Dieter Groneberg Source Type: research
CITED1 as a marker of favourable outcome in anti-endocrine treated, estrogen-receptor positive, lymph-node negative breast cancer
BMC Res Notes. 2023 Jun 15;16(1):105. doi: 10.1186/s13104-023-06376-1.ABSTRACTOBJECTIVE: To investigate CITED1 as a potential biomarker of anti-endocrine response and breast cancer recurrence, given its previously determined role in mediating estrogen-dependant transcription. The study is a continuation of earlier work establishing the role of CITED1 in mammary gland development.RESULTS: CITED1 mRNA is associated with estrogen-receptor positivity and selectively expressed in the GOBO dataset of cell lines and tumours representing the luminal-molecular subtype. In patients treated with tamoxifen, higher CITED1 correlated wi...
Source: Cell Research - June 15, 2023 Category: Cytology Authors: Malin Dahlgren Barbara Lettiero Hina Dalal Kira M årtensson Alexander Gaber Bj örn Nodin Sofia K Gruvberger-Saal Lao H Saal Jillian Howlin Source Type: research
Innovative Thiosemicarbazones that Induce Multi-Modal Mechanisms to Down-Regulate Estrogen-, Progesterone-, Androgen- and Prolactin-Receptors in Breast Cancer
Pharmacol Res. 2023 May 25:106806. doi: 10.1016/j.phrs.2023.106806. Online ahead of print.ABSTRACTThe estrogen receptor-α (ER-α) is a key driver of breast cancer (BC) and the ER-antagonist, tamoxifen, is a central pillar of BC treatment. However, cross-talk between ER-α, other hormone and growth factor receptors enables development of de novo resistance to tamoxifen. Herein, we mechanistically dissect the activity of a new class of anti-cancer agents that inhibit multiple growth factor receptors and down-stream signaling for the treatment of ER-positive BC. Using RNA sequencing and comprehensive protein expression analy...
Source: Cell Research - May 27, 2023 Category: Cytology Authors: Faten Shehadeh-Tout Heloisa H Milioli Suraya Roslan Patric J Jansson Mahendiran Dharmasivam Dinny Graham Robin Anderson Tharushi Wijesinghe Mahan Gholam Azad Des R Richardson Zaklina Kovacevic Source Type: research
Celastrol enhances tamoxifen sensitivity in the treatment of triple negative breast cancer via mitochondria mediated apoptosis pathway
CONCLUSION: CEL can promote apoptosis and enhance the TAM sensitivity in TNBC treatment through a mitochondria-mediated pathway.PMID:37193187 | PMC:PMC10182490
Source: Cell Research - May 16, 2023 Category: Cytology Authors: Bingjie Qi Qigao Yan Pei Zhang Yu Ren Huijuan Liu Tingting Liu Lingli Zhu Yu Chen Source Type: research
A Novel Quantitative Electrocardiography Strategy Reveals the Electroinhibitory Effect of Tamoxifen on the Mouse Heart
J Cardiovasc Transl Res. 2023 May 8. doi: 10.1007/s12265-023-10395-5. Online ahead of print.ABSTRACTTamoxifen, a selective estrogen receptor modulator, was initially used to treat cancer in women and more recently to induce conditional gene editing in rodent hearts. However, little is known about the baseline biological effects of tamoxifen on the myocardium. In order to clarify the short-term effects of tamoxifen on cardiac electrophysiology of myocardium, we applied a single-chest-lead quantitative method and analyzed the short-term electrocardiographic phenotypes induced by tamoxifen in the heart of adult female mice. W...
Source: Cell Research - May 8, 2023 Category: Cytology Authors: Ming Xie Shuoji Zhu Gang Liu Yijin Wu Wenkai Zhou Dingdang Yu Jinkai Wan Shenghui Xing Siqing Wang Lin Gan Ge Li Dehua Chang Hao Lai Nanbo Liu Ping Zhu Source Type: research
Synthesis, identification and evaluation of molecular docking and experimental anti-cancer and antioxidant activity of new spiro four membered ring derivatives bearing 5-nitro isatin
Nat Prod Res. 2023 Mar 30:1-8. doi: 10.1080/14786419.2023.2195178. Online ahead of print.ABSTRACTSpiro-5-nitro isatino aza-β-lactams were produced by a [2 + 2] cycloaddition of 5-nitro isatin Schiff bases [1-5] with different aromatic isocyanate and thioisocyanate. 1HNMR and 13CNMR as well as FTIR spectroscopies, were used to identify the structures of the obtained compounds. These spiro-5-nitro isatin aza- β-lactams interest to us due to their potential antioxidant and anticancer properties. The MTT assay was used to examine in vitro bioactivity testing against breast cancer (MCF-7) cell lines. From result data, compoun...
Source: Cell Research - March 30, 2023 Category: Cytology Authors: Hala Ayad Mohamed Rasheed Suaad M H Al-Majidi Source Type: research
An animal-free preclinical drug screening platform based on human precision-cut kidney slices
In conclusion, this study revealed that it is feasible to use an animal-free approach to test drug efficacy and elucidate mechanisms of action.PMID:36941637 | DOI:10.1186/s13104-023-06303-4
Source: Cell Research - March 21, 2023 Category: Cytology Authors: Henricus A M Mutsaers Michael Schou Jensen Jean-Claude Kresse Stine Julie Tingskov Mia Gebauer Madsen Rikke N ørregaard Source Type: research
Generation of p27icreER transgenic mice: A tool for inducible gene expression in supporting cells in the cochlea
In this study, a new line of iCreER transgenic mice, the p27-P2A-iCreERT2 knock-in mouse strain, was generated by inserting the P2A-iCreERT2 cassette immediately in front of the stop codon of p27, which kept the endogenous expression and function of p27 intact. Using a reporter mouse line with tdTomato fluorescence, we showed that the p27iCreER transgenic line can target all subtypes of cochlear SCs, including Claudius cells. p27-CreER activity in SCs was observed in both the postnatal and the adult stage, suggesting that this mouse strain can be useful for research work in adult cochlear HC regeneration. We then overexpre...
Source: Cell Research - March 11, 2023 Category: Cytology Authors: Yuyan Gu Yikang Huang Gaogan Jia Yanping Zhang Yan Chen Wenyan Li Source Type: research
