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Systematic review and meta-analysis of interleulin-6 inhibitors in reducing mortality for hospitalized patients with COVID-19
CONCLUSIONS: A benefit in mortality for interleukine-6 inhibitors was found, but with important differences among the scenarios analyzed in the clinical trials. Positive results are mainly caused by two randomized clinical trials which are similar in concomitant use of steroids and veryhigh mortality in critical patents. Sarilumab was poorly represented in the meta-analysis. Nevertheless, an association between the benefit and the critical/non-critical condition was not found. More randomized clinical trials, mainly focused in atients at high mortality risk, are needed to confirm the benefit of interleukine- 6 inhibitors f...
Source: Farmacia Hospitalaria - October 2, 2022 Category: Drugs & Pharmacology Authors: Emilio Jes ús Alegre-Del-Rey Silvia F énix-Caballero Francisco Javier Salmer ón-Navas Manuel David Gil-Sierra Jes ús Francisco Sierra-Sánchez Ram ón L Díaz-Alersi Rosety Source Type: research
