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Source: Cochrane Database of Systematic Reviews
Drug: Dexamethasone
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Total 87 results found since Jan 2013.
Systemic corticosteroids for the prevention of bronchopulmonary dysplasia, a network meta-analysis
CONCLUSIONS: While early treatment with moderate-dose dexamethasone or late treatment with high-dose dexamethasone may lead to the best effects for survival without BPD, the certainty of the evidence is low. There is insufficient evidence to guide this therapy with regard to plausible adverse long-term outcomes. Further RCTs with direct comparisons between systemic corticosteroid treatments are needed to determine the optimal treatment approach, and these studies should be adequately powered to evaluate survival without major neurosensory disability.PMID:37650547 | DOI:10.1002/14651858.CD013730.pub2
Source: Cochrane Database of Systematic Reviews - August 31, 2023 Category: General Medicine Authors: Susanne Hay Colleen Ovelman John Af Zupancic Lex W Doyle Wes Onland Menelaos Konstantinidis Prakeshkumar S Shah Roger Soll Source Type: research
Corticosteroid implants for chronic non-infectious uveitis
CONCLUSIONS: Our confidence is limited that local corticosteroid implants are superior to sham therapy or standard-of-care therapy in reducing the risk of uveitis recurrence. We demonstrated different effectiveness on BCVA relative to comparators in people with non-infectious uveitis. Nevertheless, the evidence suggests that these implants may increase the risk of cataract progression and IOP elevation, which will require interventions over time. To better understand the efficacy and safety profiles of corticosteroid implants, we need future trials that examine implants of different doses, used for different durations. The...
Source: Cochrane Database of Systematic Reviews - August 29, 2023 Category: General Medicine Authors: Amit Reddy Su-Hsun Liu Christopher J Brady Pamela C Sieving Alan G Palestine Source Type: research
Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants
CONCLUSIONS: The evidence is very uncertain about the effects of different corticosteroid regimens on the outcomes mortality, pulmonary morbidity, and long term neurodevelopmental impairment. Despite the fact that the studies investigating higher versus lower dosage regimens showed that higher-dosage regimens may reduce the incidence of death or neurodevelopmental impairment, we cannot conclude what the optimal type, dosage, or timing of initiation is for the prevention of BPD in preterm infants, based on current level of evidence. Further high quality trials would be needed to establish the optimal systemic postnatal cort...
Source: Cochrane Database of Systematic Reviews - March 13, 2023 Category: General Medicine Authors: Wes Onland Moniek van de Loo Martin Offringa Anton van Kaam Source Type: research
Intratympanic corticosteroids for M énière's disease
CONCLUSIONS: The evidence for intratympanic corticosteroids in the treatment of Ménière's disease is uncertain. There are relatively few published RCTs, which all consider the same type of corticosteroid (dexamethasone). We also have concerns about publication bias in this area, with the identification of two large RCTs that remain unpublished. The evidence comparing intratympanic corticosteroids to placebo or no treatment is therefore all low- or very low-certainty. This means that we have very low confidence that the effects reported are accurate estimates of the true effect of these interventions. Consensus on the app...
Source: Cochrane Database of Systematic Reviews - February 27, 2023 Category: General Medicine Authors: Katie E Webster Ambrose Lee Kevin Galbraith Natasha A Harrington-Benton Owen Judd Diego Kaski Otto R Maarsingh Samuel MacKeith Jaydip Ray Vincent A Van Vugt Brian Westerberg Martin J Burton Source Type: research
Corticosteroids for the management of cancer-related fatigue in adults with advanced cancer
CONCLUSIONS: There is insufficient evidence to support or refute the use of systemic corticosteroids in adults with cancer and CRF. We included four small studies that provided very low-certainty of evidence for the efficacy of corticosteroids in the management of CRF. Further high-quality randomised controlled trials with larger sample sizes are required to determine the effectiveness of corticosteroids in this setting.PMID:36688471 | PMC:PMC9869433 | DOI:10.1002/14651858.CD013782.pub2
Source: Cochrane Database of Systematic Reviews - January 23, 2023 Category: General Medicine Authors: Amy Sandford Alison Haywood Kirsty Rickett Phillip Good Sohil Khan Karyn Foster Janet R Hardy Source Type: research
Corticosteroid implants for chronic non-infectious uveitis
CONCLUSIONS: Our confidence is limited that local corticosteroid implants are superior to sham therapy or standard-of-care therapy in reducing the risk of uveitis recurrence. We demonstrated different effectiveness on BCVA relative to comparators in people with non-infectious uveitis. Nevertheless, the evidence suggests that these implants may increase the risk of cataract progression and IOP elevation, which will require interventions over time. To better understand the efficacy and safety profiles of corticosteroid implants, we need future trials that examine implants of different doses, used for different durations. The...
Source: Cochrane Database of Systematic Reviews - January 16, 2023 Category: General Medicine Authors: Amit Reddy Su-Hsun Liu Christopher J Brady Pamela C Sieving Alan G Palestine Source Type: research
Glucocorticoids for croup in children
CONCLUSIONS: The evidence that glucocorticoids reduce symptoms of croup at two hours, shorten hospital stays, and reduce the rate of return visits or (re)admissions has not changed in this update. A smaller dose of 0.15 mg/kg of dexamethasone may be as effective as the standard dose of 0.60 mg/kg. More RCTs are needed to strengthen the evidence for effectiveness of low-dose dexamethasone at 0.15 mg/kg to treat croup.PMID:36626194 | DOI:10.1002/14651858.CD001955.pub5
Source: Cochrane Database of Systematic Reviews - January 10, 2023 Category: General Medicine Authors: Alex Aregbesola Clara M Tam Asha Kothari Me-Linh Le Mirna Ragheb Terry P Klassen Source Type: research
Systemic corticosteroids for the treatment of COVID-19: Equity-related analyses and update on evidence
CONCLUSIONS: Systemic corticosteroids probably slightly reduce all-cause mortality up to 30 days in people hospitalised because of symptomatic COVID-19, while the evidence is very uncertain about the effect on all-cause mortality up to 120 days. For younger people (under 70 years of age) there was a potential advantage, as well as for Black, Asian, or people of a minority ethnic group; further subgroup analyses showed no relevant effects. Evidence related to the most effective type, dose, or timing of systemic corticosteroids remains immature. Currently, there is no evidence on asymptomatic or mild disease (non-hospitalise...
Source: Cochrane Database of Systematic Reviews - November 17, 2022 Category: General Medicine Authors: Carina Wagner Mirko Griesel Agata Mikolajewska Maria-Inti Metzendorf Anna-Lena Fischer Miriam Stegemann Manuel Spagl Avinash Anil Nair Jefferson Daniel Falk Fichtner Nicole Skoetz Source Type: research
Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth
CONCLUSIONS: Overall, it remains unclear whether there are important differences between dexamethasone and betamethasone, or between one regimen and another. Most trials compared dexamethasone versus betamethasone. While for most infant and early childhood outcomes there may be no difference between these drugs, for several important outcomes for the mother, infant and child the evidence was inconclusive and did not rule out significant benefits or harms. The evidence on different antenatal corticosteroid regimens was sparse, and does not support the use of one particular corticosteroid regimen over another.PMID:35943347 |...
Source: Cochrane Database of Systematic Reviews - August 9, 2022 Category: General Medicine Authors: Myfanwy J Williams Jenny A Ramson Fiona C Brownfoot Source Type: research
