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Source: Cell Research
Drug: Dexamethasone
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Total 84 results found since Jan 2013.
Resistance exercise alleviates dexamethasone-induced muscle atrophy via Sestrin2/MSTN pathway in C57BL/6J mice
CONCLUSION: Taken together, our results indicated that Sestrin2 may serve as an effective molecule that mimics the protective effect of resistance exercise on dexamethasone-induced muscle atrophy.PMID:37709247 | DOI:10.1016/j.yexcr.2023.113779
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Yang Yang Xuege Yang Yating Huang Sujuan Liu Yanmei Niu Li Fu Source Type: research
Quantification of transcriptome changes to investigate the role of glucocorticoid receptor-RNA binding during dexamethasone treatment
The objective of our study was to further characterize the relationship between GR function and RNA binding by measuring changes in the glucocorticoid-driven transcriptome in the presence of a GR mutant that exhibited reduced RNA affinity.DATA DESCRIPTION: GR was activated in three cell lines containing GR constructs (GR-HaloTag). One of the cell lines contained a wild-type GR-HaloTag. Another contained GR-HaloTag with a mutation that reduced RNA affinity and slightly reduced DNA affinity. The third cell line contained GR-HaloTag with a mutation that only slightly reduced DNA affinity. All three cell lines were treated wit...
Source: Cell Research - August 23, 2023 Category: Cytology Authors: Nickolaus C Lammer Mary A Allen Robert T Batey Deborah S Wuttke Source Type: research
Effects of pharmacological doses of niacin on subacute glucocorticoid-induced testicular damage in rats
In conclusion, niacin administration at pharmacological doses dose-dependently ameliorates the destructive effects of dexamethasone on sperm motility, Johnsen score, and testicular cell apoptosis in rats with the latter can be considered a decisive mechanism for its positive effects on testis.PMID:37589322 | DOI:10.1002/prp2.1128
Source: Cell Research - August 17, 2023 Category: Cytology Authors: E Azimi Zangabad Tahoora Shomali L Roshangar Source Type: research
Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19
Res Sq. 2023 Aug 3:rs.3.rs-3168149. doi: 10.21203/rs.3.rs-3168149/v1. Preprint.ABSTRACTDexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. We performed bulk and single-cell RNA sequencing of the lower respiratory tract and blood, and plasma cytokine profiling to study the effect of dexamethasone on systemic and pulmonary immune cells. We find decreased signatures of antigen presentation, T cell recruitment, and viral injury in patients treated with dexamethasone. We identify comp...
Source: Cell Research - August 14, 2023 Category: Cytology Authors: Gabriela Fragiadakis Lucile Neyton Ravi Patel Aartik Sarma Ucsf Comet Consortium Andrew Willmore Sidney Carrillo Haller Kristen Kangelaris Walter Eckalbar David Erle Matthew Krummel Carolyn Hendrickson Prescott Woodruff Charles Langelier Carolyn Calfee Source Type: research
Mesenchymal stem cells alleviate dexamethasone-induced muscle atrophy in mice and the involvement of ERK1/2 signalling pathway
CONCLUSIONS: ADSCs restore the pathogenesis of Dex-induced muscle atrophy with an increased number of type I fibres, stronger muscle strength, faster recovery rate and more anti-fatigue ability via ERK1/2 signalling pathway. The inhibition of muscle atrophy-associated genes by ADSCs offered this treatment as an intervention option for muscle-associated diseases. Taken together, our findings suggested that adipose-derived mesenchymal stem cell therapy could be a new treatment option for patient with Dex-induced muscle atrophy.PMID:37542297 | DOI:10.1186/s13287-023-03418-0
Source: Cell Research - August 4, 2023 Category: Cytology Authors: Belle Yu-Hsuan Wang Allen Wei-Ting Hsiao Hoi Ting Shiu Nicodemus Wong Amanda Yu-Fan Wang Chien-Wei Lee Oscar Kuang-Sheng Lee Wayne Yuk-Wai Lee Source Type: research
IgG4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection
Leuk Res Rep. 2023 Jul 8;20:100379. doi: 10.1016/j.lrr.2023.100379. eCollection 2023.ABSTRACTIgG4 plasma cell neoplasm and myeloma are rare disease entities, not associated with systemic fibroinflammatory IgG4 related disease. We herein present a case of IgG4 plasma cell neoplasm in a liver transplant biopsy. A 55 year old female was treated with living donor transplant and had a complicated post-operative course. Three months post-transplant, she presented with small for size syndrome, biliary stricture, and inferior vena cava stenosis. Concomitant liver biopsy revealed mild acute cellular rejection with central perivenul...
Source: Cell Research - July 31, 2023 Category: Cytology Authors: Amarpreet Bhalla Qiang Liu Yanan Fang Jay H Lefkowitch Source Type: research
Characterization of extracellular matrix deposited by segmental trabecular meshwork cells
CONCLUSION: Regardless of a direct correlation between matrix stiffness and crosslinks, we observed distinct differences in the composition and mechanics of the matrices deposited by segmental flow cells. These results suggest distinct differences in cellular identify and likely a basis for mechanical memory post isolation and culture. Nevertheless, we conclude that although a mechanistic basis for matrix stiffness was undetermined in this study, it is a viable tool to study cell-matrix interactions and further our understanding of trabecular meshwork pathobiology.PMID:37506755 | DOI:10.1016/j.exer.2023.109605
Source: Cell Research - July 28, 2023 Category: Cytology Authors: VijayKrishna Raghunathan Andrews Nartey Kamesh Dhamodaran Hasna Baidouri Julia A Staverosky Kate E Keller Keith Zientek Ashok Reddy Ted Acott Janice A Vranka Source Type: research
Dereplication of polar extracts from < em > Croton antisyphiliticus < /em > Mart. roots and its anti-inflammatory and antinociceptive potential
Nat Prod Res. 2023 Jul 10:1-5. doi: 10.1080/14786419.2023.2233672. Online ahead of print.ABSTRACTCroton antisyphiliticus Mart. is a plant popularly used in folk medicine by traditional communities from Brazilian savannah to treat general inflammation. According to ethnopharmacological data, this specie can be considered a source of biologically active molecules for the development of new drugs. Thereby, this study reports the results of the dereplication approach of C. antisyphiliticus roots extracts and the in vivo evaluation of its potential antinociceptive and anti-inflammatory in albino Swiss mice. Based on HPLC couple...
Source: Cell Research - July 10, 2023 Category: Cytology Authors: Jorge Luiz Souza Sim ão Stephanie Vilela Prado Alana Kelyene Pereira Gerso Pereira Alexandre N úbia Alves Mariano Teixeira Pires Gomide Marcia Matos da Silva Dionys de Souza Almeida Aline Nazareth Martins Daiany Priscilla Bueno da Silva Elson Alves da C Source Type: research
The Effect of dexamethasone on lipopolysaccharide-induced Inflammation of Endothelial Cells of the Blood-brain Barrier/Brain Capillaries
CONCLUSION: These results indicate that treatment of brain vascular inflammation with low doses of Dex should be advocated, while higher doses promote vascular inflammation.PMID:37403388 | DOI:10.2174/1567202620666230703145707
Source: Cell Research - July 5, 2023 Category: Cytology Authors: Tershlin Jeftha Khayelihle Brian Makhathini David Fisher Source Type: research
Schisandrin A regulates the Nrf2 signaling pathway and inhibits NLRP3 inflammasome activation to interfere with pyroptosis in a mouse model of COPD
In conclusion, our study shows that SchA treatment can inhibit the production of ROS and the activation of the NLRP3 inflammasome by upregulating Nrf-2, thereby producing anti-inflammatory effects and reducing lung injury in COPD model mice. More importantly, SchA exhibited similar anti-inflammatory effects to dexamethasone in COPD model mice, and we did not observe substantial side effects of SchA treatment. The high safety of SchA makes it a potential candidate drug for the treatment of COPD.PMID:37400851 | PMC:PMC10316617 | DOI:10.1186/s40001-023-01190-8
Source: Cell Research - July 3, 2023 Category: Cytology Authors: Jiamin Zeng Sida Liao Zhu Liang Caiping Li Yuewen Luo Kexin Wang Dapeng Zhang Lan Lan Suzhen Hu Wanyan Li Ran Lin Zichen Jie Yuanlong Hu Shiting Dai Zhimin Zhang Source Type: research
Dexamethasone induces cancer mitigation and irreversible senescence in lung cancer cells via damaging cortical actin and sustained hyperphosphorylation of pRb
Steroids. 2023 Jun 30:109269. doi: 10.1016/j.steroids.2023.109269. Online ahead of print.ABSTRACTActivation of the glucocorticoid receptors by its cognate ligand, dexamethasone (DEX) is commonly used as an adjuvant treatment in solid tumors. However, its direct effect on cancerous phenotype is not fully understood. We explored the effect and molecular mechanisms of DEX action in lung cancer. In in vitro experiments, DEX treatment causes decrease in migration, invasion and colony formation ability of A549 cells even at lower doses. DEX also decreased adhesion of A549 cells by reducing the formation of cortical actin. Treatm...
Source: Cell Research - July 2, 2023 Category: Cytology Authors: Swati Srivastava Shumaila Siddiqui Samradhi Singh Sangita Chowdhury Vishal Upadhyay Arppita Sethi Arun Kumar Trivedi Source Type: research
Tanshinone I alleviates steroid-induced osteonecrosis of femoral heads and promotes angiogenesis: in vivo and in vitro studies
CONCLUSIONS: This study demonstrates that TsI alleviates SIONFH and promotes angiogenesis by regulating SOX11 expression. Our work would provide new evidence for the application of TsI to treat SIONFH.PMID:37391758 | DOI:10.1186/s13018-023-03934-y
Source: Cell Research - June 30, 2023 Category: Cytology Authors: Kai Sun Yuman Xue Xin Zhang Xiaodong Li Jun Zhao Xilin Xu Xiaofeng Zhang Fubiao Yang Source Type: research
Dissecting the mechanisms underlying the Cytokine Release Syndrome (CRS) mediated by T Cell Bispecific Antibodies
CONCLUSION: Our work sheds a new light on the cellular and molecular players involved in cytokine release driven by TCBs and provides rationale for the prevention of CRS in patients treated with TCBs.PMID:37379429 | DOI:10.1158/1078-0432.CCR-22-3667
Source: Cell Research - June 28, 2023 Category: Cytology Authors: Gabrielle Leclercq-Cohen Nathalie Steinhoff Llucia Albert í-Servera Sina Nassiri Sabrina Danilin Emily Piccione Emilio Y ángüez Tamara H üsser Sylvia Herter Stephan Schmeing Petra Gerber Petra Schwalie Johannes Sam Stefanie Briner Sylvia Jenni Roberta Source Type: research
Delayed spontaneous remission of acquired factor V inhibitor refractory to immunosuppressive therapy with pregnancy-associated improvement
Discussion: The use of an activated bypassing agent for bleeding control is effective in patients with severe AFVI. The presented case is unique because the treatment regimens included multiple combinations of immunosuppressive agents. This demonstrates that AFVI patients may undergo spontaneous remission even after multiple courses of ineffective immunosuppressive protocols. Additionally, pregnancy-associated improvement of AFVI is an important finding that warrants further investigation.PMID:37334173 | PMC:PMC10272408 | DOI:10.3389/pore.2023.1611250
Source: Cell Research - June 19, 2023 Category: Cytology Authors: Andrea Cegl édi J ános Dolgos M ónika Fekete L ászló Gopcsa Andrea V árkonyi Be áta Vilimi G ábor Mikala Imre Bod ó Source Type: research
