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Involvement of angiotensin-(1–7) in the neuroprotection of captopril against focal cerebral ischemia
In this study, we evaluated this hypothesis using a rat model of focal cerebral ischemia. We revealed that brain ACE2 activity and Ang-(1–7) levels were significantly elevated following captopril treatment in rats with focal cerebral ischemia. More importantly, we showed that the neuroprotection provided by captopril was partially reversed by A-779, an antagonist for Ang-(1–7) receptor MAS1, indicating that Ang-(1–7) was involved in the neuroprotection of captopril. These findings have uncovered new mechanisms by which captopril protects against focal cerebral ischemia and further suggest that captopril may have prac...
Source: Neuroscience Letters - September 21, 2018 Category: Neuroscience Source Type: research

Involvement of angiotensin-(1-7) in the neuroprotection of captopril against focal cerebral ischemia
In this study, we evaluate this hypothesis using a rat model of focal cerebral ischemia. We revealed that brain ACE2 activity and Ang-(1-7) levels were significantly elevated following captopril treatment in rats with focal cerebral ischemia. More importantly, we showed that the neuroprotection provided by captopril was partially reversed by A-779, an antagonist for Ang-(1-7) receptor MAS1, indicating that Ang-(1-7) was involved in the neuroprotection of captopril. These findings have uncovered new mechanisms by which captopril protects against focal cerebral ischemia and further suggest that captopril may have practical c...
Source: Neuroscience Letters - September 14, 2018 Category: Neuroscience Source Type: research