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Post-stroke losartan and captopril treatments arrest hemorrhagic expansion in SHRsp without lowering blood pressure.
Abstract We assessed the ability of poststroke losartan and captopril treatment to attenuate hematoma expansion and plasma extravasation after intracerebral hemorrhagic stroke in Kyoto-Wistar stroke-prone hypertensive rats (SHRsp). Cerebrum volume, herniation and surface areas exhibiting new and old hemorrhages and albumin extravasation were measured prior to and after stroke and following 30 and 60 days of post-stroke losartan or captopril treatment in Evans Blue dye perfused brains. Lesion morphology was studied in serial sections. Losartan or captopril treatment initiated at stroke prevented death for 60 da...
Source: Vascular Pharmacology - August 13, 2018 Category: Drugs & Pharmacology Authors: Smeda JS, Watson D, Stuckless J, Neghandi A Tags: Vascul Pharmacol Source Type: research

Cerebrovascular recovery after stroke with individual and combined losartan and captopril treatment of SHRsp.
Abstract We assessed whether the superior restoration of cerebrovascular function after hemorrhagic stroke by losartan versus captopril treatment was due to better BP, uremia, uricaemia, or aldosterone control in Kyoto Wistar stroke-prone-hypertensive rats and evaluated whether elevated angiotensin II (A2) levels enhanced the effectiveness of losartan treatment. Constriction was studied in the middle cerebral arteries (MCAs) using a pressure myograph. Post-stroke survival increased from 21 to 310 and 189days respectively with losartan and captopril treatment. Neither treatment reduced BP, both reversed uremia and ...
Source: Vascular Pharmacology - August 18, 2017 Category: Drugs & Pharmacology Authors: Smeda JS, Daneshtalab N Tags: Vascul Pharmacol Source Type: research