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Oral antineoplastic agent interactions with medicinal plants and food: an issue to take into account
ConclusionA review of interactions of medicinal plants and food should be taken into account in the management of OAAs, since more than half have interactions with MPs and food, of which 70.3  % are considered important. The most relevant are HSJ, grapefruit, ginseng and tobacco. This review is intended to serve as a support to all healthcare professionals at the time of prescribing or dispensing OAAs.
Source: Journal of Cancer Research and Clinical Oncology - September 30, 2016 Category: Cancer & Oncology Source Type: research

Abstract 37: Role and regulation of CYP24A1 in endometrial cancer
The cytochrome P450 enzyme, 24-hydroxylase, encoded by CYP24A1 is critical for the catabolism of 1,25(OH)2D3 (calcitriol). The unbalanced high levels of CYP24A1 seem to be a determinant of calcitriol resistance in tumors. We have previously shown that progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells. In the present study, we evaluated CYP24A1 protein expression in normal and endometrial tumor tissues, assessed the effect of progesterone and calcitriol on CYP24A1 and its spliced variant expression in endometrial cancer cell ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Bokhari, A. A., Lee, L. R., Dewayne, R., Hamilton, C. A., Maxwell, G. L., Rodriguez, G. C., Syed, V. Tags: Molecular and Cellular Biology Source Type: research