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Drug: Medroxyprogesterone
Nutrition: Antidoxidants
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Total 6 results found since Jan 2013.
Melatonin attenuates glucocorticoid effect induced by medroxyprogesterone acetate in rats
Gen Comp Endocrinol. 2021 Dec 1;316:113959. doi: 10.1016/j.ygcen.2021.113959. Online ahead of print.ABSTRACTMedroxyprogesterone acetate (MPA) acts on glucocorticoid receptors and, when it is in excess, can cause clinical disorders comparable to hyperadrenocorticism. Melatonin (MEL) is a hormone with potent antioxidant and anti-glucocorticoid activity and it can be beneficial in the excessive activation of glucocorticoid receptors. To evaluate the protective effects of MEL on the glucocorticoid effect of MPA, 34 male Wistar rats were randomized into four groups: CON (control), MEL, MPA, and MPA + MEL. The animals were treat...
Source: General and Comparative Endocrinology - December 3, 2021 Category: Endocrinology Authors: Mariana Moreira Andraschko Mara Ta ís de Carvalho Hugo Cardoso Martins Pires Hellen Dorneles de Deus Carla Mart í Castelló Liliana Borges de Menezes Danieli Brolo Martins Marina Pacheco Miguel Source Type: research
